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L A Santiago
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D A Santiago
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L C Faustino
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A Cordeiro
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P C Lisboa Instituto de Biofísica Carlos Chagas Filho, Departamento de Ciências Fisiológicas, Department of Pediatrics and Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil

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F E Wondisford Instituto de Biofísica Carlos Chagas Filho, Departamento de Ciências Fisiológicas, Department of Pediatrics and Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil

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C C Pazos-Moura
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T M Ortiga-Carvalho
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Introduction Thyroid hormones (TH) exert profound effects on metabolism and growth. Most of TH actions occur through the nuclear TH receptors (TRs), which are ligand-dependent and ligand-independent transcription factors ( Yen 2001 ). TRs are

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Eleftheria Diakogiannaki Peninsula Medical School, Institute of Biomedical and Clinical Science, John Bull Building, Plymouth PL6 8BU, UK

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Hannah J Welters Peninsula Medical School, Institute of Biomedical and Clinical Science, John Bull Building, Plymouth PL6 8BU, UK

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Noel G Morgan Peninsula Medical School, Institute of Biomedical and Clinical Science, John Bull Building, Plymouth PL6 8BU, UK

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transcription factor 4 (ATF4), GRP78 (Santa Cruz), eukaryotic initiation factor 2α (eIF2α), p-eIF2α (Cell Signalling), CHOP-10, β-actin, histone H3 (Sigma). The dilution used in all cases was 1:1000. Incubation lasted for 4 h at room temperature. The membrane

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K A Berghorn Department of Biomedical Sciences, Cornell University, Ithaca, New York, USA
Developmental Skin Biology Unit, NIAMS, Bethesda, Maryland, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA

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P A Clark Department of Biomedical Sciences, Cornell University, Ithaca, New York, USA
Developmental Skin Biology Unit, NIAMS, Bethesda, Maryland, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA

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B Encarnacion Department of Biomedical Sciences, Cornell University, Ithaca, New York, USA
Developmental Skin Biology Unit, NIAMS, Bethesda, Maryland, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA

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C J DeRegis Department of Biomedical Sciences, Cornell University, Ithaca, New York, USA
Developmental Skin Biology Unit, NIAMS, Bethesda, Maryland, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA

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J K Folger Department of Biomedical Sciences, Cornell University, Ithaca, New York, USA
Developmental Skin Biology Unit, NIAMS, Bethesda, Maryland, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA

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M I Morasso Department of Biomedical Sciences, Cornell University, Ithaca, New York, USA
Developmental Skin Biology Unit, NIAMS, Bethesda, Maryland, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA

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M J Soares Department of Biomedical Sciences, Cornell University, Ithaca, New York, USA
Developmental Skin Biology Unit, NIAMS, Bethesda, Maryland, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA

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M W Wolfe Department of Biomedical Sciences, Cornell University, Ithaca, New York, USA
Developmental Skin Biology Unit, NIAMS, Bethesda, Maryland, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA

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M S Roberson Department of Biomedical Sciences, Cornell University, Ithaca, New York, USA
Developmental Skin Biology Unit, NIAMS, Bethesda, Maryland, USA
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA

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Dlx3 and activator protein (AP)-2γ, a combination of regulatory factors shared with the glyco-protein hormone α subunit promoter ( Peng & Payne 2002 ). The conserved nature of these two transcriptional regulators supports the possibility that Dlx3 and

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Barry N Madison Department of Integrative Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario, Canada N1G 2W1

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Patrick T K Woo Department of Integrative Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario, Canada N1G 2W1

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Nicholas J Bernier Department of Integrative Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario, Canada N1G 2W1

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template input and transcriptional efficiency, the input values were normalized to the expression level of the housekeeping gene elongation factor 1α ( ef1 α ). Initial pilot experiments revealed no changes in ef1 α expression with parasite infection

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Manon M Roustit
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Joan M Vaughan Department of Comparative Biomedical Sciences, Laboratory of Neuronal Structure and Function, Queen's Medical Research Institute, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK

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Pauline M Jamieson Department of Comparative Biomedical Sciences, Laboratory of Neuronal Structure and Function, Queen's Medical Research Institute, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK

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Mark E Cleasby
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transcription factors in macrophages ( Tsatsanis et al . 2006 ). These data contrast with the reduced IRS1 and AKT phosphorylation observed in the transgenic mice ( Jamieson et al . 2011 ), which may have been the result of the reduced circulating insulin

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Jane A Mitchell Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Cardiac Medicine, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK

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Mark J Paul-Clark Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Cardiac Medicine, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK

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Graham W Clarke Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Cardiac Medicine, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK

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Shaun K McMaster Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Cardiac Medicine, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK

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Neil Cartwright Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Cardiac Medicine, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK

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interaction between TLR4 and other proteins and factors result in the sensing of LPS by cells. First, we shall consider the effects of LPS in vitro and in vivo , which would explain why it is very useful as a model of inflammation. LPS mimics many

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Astrid Chamson-Reig Lawson Health Research Institute, St Joseph’s Health Care, 268 Grosvenor Street Room H404, London, Ontario, Canada N6A 4V2
Departments of Medicine,
Physiology and Pharmacology,
Paediatrics, University of Western Ontario, London, Ontario, Canada N6A 4V2

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Sandra M Thyssen Lawson Health Research Institute, St Joseph’s Health Care, 268 Grosvenor Street Room H404, London, Ontario, Canada N6A 4V2
Departments of Medicine,
Physiology and Pharmacology,
Paediatrics, University of Western Ontario, London, Ontario, Canada N6A 4V2

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Edith Arany Lawson Health Research Institute, St Joseph’s Health Care, 268 Grosvenor Street Room H404, London, Ontario, Canada N6A 4V2
Departments of Medicine,
Physiology and Pharmacology,
Paediatrics, University of Western Ontario, London, Ontario, Canada N6A 4V2

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David J Hill Lawson Health Research Institute, St Joseph’s Health Care, 268 Grosvenor Street Room H404, London, Ontario, Canada N6A 4V2
Departments of Medicine,
Physiology and Pharmacology,
Paediatrics, University of Western Ontario, London, Ontario, Canada N6A 4V2

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was performed using Taqman probe technologies in an ABI PRISM 7900HT Sequence Detection System (Applied Biosystems, Foster City, CA, USA) to determine the relative abundance of the transcription factor Pdx-1 (Mn00435565_m1) and nestin (Rn00564394_m1

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Nasser Al-Shanti Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Hassall Road, Alsager, Cheshire ST7 2HL, England, UK

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Claire E Stewart Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Hassall Road, Alsager, Cheshire ST7 2HL, England, UK

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fibroblast growth factor, that mediate their biological effects through various intracellular signalling cascades, such as Janus kinase/signal transducers and activators of transcription, Ras/mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3

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Mi-Hyun Kim
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Jae-Hwan Jee Division of Endocrinology and Metabolism, Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, 50 Ilwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea

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Sunyoung Park
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Myung-Shik Lee Division of Endocrinology and Metabolism, Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, 50 Ilwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea

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Kwang-Won Kim Division of Endocrinology and Metabolism, Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, 50 Ilwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea

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Moon-Kyu Lee Division of Endocrinology and Metabolism, Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, 50 Ilwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea

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transcription factor 7-like 2 (TCF7L2), which has its binding site in the G2 enhancer element of proglucagon ( G lu ), a precursor of GLP1 ( Akiyama 2000 ). Insulin enhances GLP1 production via inhibition of glycogen synthase kinase (GSK)-3β

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Shona Wood Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK

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Andrew Loudon Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK

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, including GFAP and S100 protein ( Hazlerigg et al . 2001 ). The PT has a distinct developmental origin from the rest of the pituitary gland, involving the bHLH transcription factor hairy enhancer of split ( HES1 ) as a PT-specific differentiating factor

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