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Dieuwertje C E Spaanderman Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Mark Nixon BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Jacobus C Buurstede Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Hetty H C M Sips Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Maaike Schilperoort Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Eline N Kuipers Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Emma A Backer Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Sander Kooijman Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Patrick C N Rensen Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Natalie Z M Homer BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Brian R Walker BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Institute for Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

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Onno C Meijer Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Jan Kroon Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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for 24 h. Cells were harvested in Tripure for further RT-PCR analysis of GR-responsive transcripts. Murine-immortalized brown adipocytes were generated and cultured as previously published ( Kroon et al . 2018 ) and exposure with DHT and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0503
Volume/Issue:
Volume 240: Issue 1
Free access
Matthew J VandeKopple Department of Radiation Oncology, The Ohio State University, Columbus, Ohio, USA

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Jinghai Wu Department of Radiation Oncology, The Ohio State University, Columbus, Ohio, USA

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Lisa A Baer Dorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA

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Naresh C Bal Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA

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Santosh K Maurya Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA

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Anuradha Kalyanasundaram Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA

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Muthu Periasamy Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA

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Kristin I Stanford Dorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA

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Amato J Giaccia Department of Radiation Oncology, Stanford University, Stanford, CA, USA

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Nicholas C Denko Department of Radiation Oncology, The Ohio State University, Columbus, Ohio, USA

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Ioanna Papandreou Department of Radiation Oncology, The Ohio State University, Columbus, Ohio, USA

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 mM glucose, 100 mM HEPES, 4% BSA, 1.5 mg/mL collagenase A (Sigma), 100 U/mL penicillin and 100 µg/mL streptomycin. Cells were expanded in DMEM supplemented with 15% FBS and were used within two passages. For SVF differentiation into brown adipocytes

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0289
Volume/Issue:
Volume 235: Issue 1
Free access
M Skrzypski Department of Animal Physiology and Biochemistry, Poznań University of Life Sciences, Poznań

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M Billert Department of Animal Physiology and Biochemistry, Poznań University of Life Sciences, Poznań

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K W Nowak Department of Animal Physiology and Biochemistry, Poznań University of Life Sciences, Poznań

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M Z Strowski Department of Hepatology and Gastroenterology & The Interdisciplinary Centre of Metabolism: Endocrinology, Diabetes and Metabolism, Charité-University Medicine Berlin, Berlin, Germany
Park-Klinik Weissensee, Internal Medicine – Gastroenterology, Berlin, Germany

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processes are conferred via UCP1 protein ( Nicholls et al . 1978 ). The capacity of brown adipocytes to generate heat is precisely controlled by orchestration of environmental and hormonal factors as well as the sympathetic nervous system ( Richard et al

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0122
Volume/Issue:
Volume 238: Issue 2
Free access
Chunchun Wei Department of Pathophysiology, Naval Medical University, Shanghai, China
Department of Physiology, Naval Medical University, Shanghai, China

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Xianhua Ma Department of Pathophysiology, Naval Medical University, Shanghai, China

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Kai Su Department of Pathophysiology, Naval Medical University, Shanghai, China

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Shasha Qi Department of Pathophysiology, Naval Medical University, Shanghai, China

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Yuangang Zhu The State Key Laboratory of Membrane Biology, Center for Life Sciences and Institute of Molecular Medicine, Peking University, Beijing, China

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Junjian Lin Department of Pathophysiology, Naval Medical University, Shanghai, China

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Chenxin Wang The State Key Laboratory of Membrane Biology, Center for Life Sciences and Institute of Molecular Medicine, Peking University, Beijing, China

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Rui Yang Department of Pathophysiology, Naval Medical University, Shanghai, China

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Xiaowei Chen The State Key Laboratory of Membrane Biology, Center for Life Sciences and Institute of Molecular Medicine, Peking University, Beijing, China

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Weizhong Wang Department of Physiology, Naval Medical University, Shanghai, China

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Weiping J Zhang Department of Pathophysiology, Naval Medical University, Shanghai, China
NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin, China

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, Rowland et al . 2015 , Bal et al . 2017 ). Mitochondrial function is the basis for NST of brown adipocytes. Mature mitochondria are highly dynamic with fission and fusion processes, which are essential for mitochondrion renewal and activity. There are

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0498
Volume/Issue:
Volume 245: Issue 3
Restricted access
S Kralisch University of Leipzig, Department of Internal Medicine III, Ph-Rosenthal-Str. 27, 04103 Leipzig, Germany

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U Lossner University of Leipzig, Department of Internal Medicine III, Ph-Rosenthal-Str. 27, 04103 Leipzig, Germany

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M Bluher University of Leipzig, Department of Internal Medicine III, Ph-Rosenthal-Str. 27, 04103 Leipzig, Germany

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R Paschke University of Leipzig, Department of Internal Medicine III, Ph-Rosenthal-Str. 27, 04103 Leipzig, Germany

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M Stumvoll University of Leipzig, Department of Internal Medicine III, Ph-Rosenthal-Str. 27, 04103 Leipzig, Germany

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M Fasshauer University of Leipzig, Department of Internal Medicine III, Ph-Rosenthal-Str. 27, 04103 Leipzig, Germany

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-1 is induced in brown adipocytes by isoproterenol We tested whether isoproterenol’s effect on TIMP-1 mRNA is specific for 3T3-L1 adipocytes. For this purpose, differentiated immortalized brown adipocytes were treated with 10 μM

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06645
Volume/Issue:
Volume 189: Issue 3
Free access
Abdoulaye Diané Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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Nikolina Nikolic Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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Alexander P Rudecki Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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Shannon M King Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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Drew J Bowie Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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Sarah L Gray Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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β-adrenergic agonists or thiazolidinediones ( Ohno et al . 2012 , Wu et al . 2012 , Schulz & Tseng 2013 ). Brite adipocytes not only present gene expression signatures similar to those of canonical brown adipocytes (i.e. uncoupling protein 1

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0316
Volume/Issue:
Volume 222: Issue 3
Free access
Esther Paulo Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA

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Dongmei Wu Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA

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Peter Hecker Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA

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Yun Zhang Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA

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Biao Wang Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA

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gene profiling approaches have indicated that interscapular brown fat from human infants and neck brown fat from human adults shares features with classical murine brown adipocytes, while supraclavicular fat of adult humans mainly consists of beige

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0173
Volume/Issue:
Volume 239: Issue 2
Free access
Asuka Mano-Otagiri Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Hisayuki Ohata Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Azusa Iwasaki-Sekino Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Takahiro Nemoto Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Tamotsu Shibasaki Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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or ARC increases food intake and RQ ( Currie et al . 2005 ). Therefore, the central effect of ghrelin on energy homeostasis may be mediated through the activation of GHS-R1a in the PVN and ARC. Brown adipocytes are important in the regulation of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0374
Volume/Issue:
Volume 201: Issue 3
Free access
Manuela Elsen Paul-Langerhans-Group for Integrative Physiology, German Diabetes Center, Auf'm Hennekamp 65, 40225 Düsseldorf, Germany

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Silja Raschke Paul-Langerhans-Group for Integrative Physiology, German Diabetes Center, Auf'm Hennekamp 65, 40225 Düsseldorf, Germany

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Jürgen Eckel Paul-Langerhans-Group for Integrative Physiology, German Diabetes Center, Auf'm Hennekamp 65, 40225 Düsseldorf, Germany

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. 2009 , Zingaretti et al . 2009 ) and confirmed the existence of an inverse correlation between BMI and BAT activity. These observations have aroused considerable interest in the therapeutic potential of brown adipocytes for inducing weight loss, and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0189
Volume/Issue:
Volume 222: Issue 1
Free access
Kevin J P Ryan Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Loughborough, Leics LE12 5RD, UK

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Zoe C T R Daniel Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Loughborough, Leics LE12 5RD, UK

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Lucinda J L Craggs Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Loughborough, Leics LE12 5RD, UK

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Tim Parr Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Loughborough, Leics LE12 5RD, UK

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John M Brameld Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Loughborough, Leics LE12 5RD, UK

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adipogenic media, suggesting that this concentration (10 −5  M) may have a different effect to the other concentrations, possibly involving anti-differentiation, pro-apoptotic and/or toxic effects. Expression of gene markers of brown adipocytes As 1,25(OH) 2

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0234
Volume/Issue:
Volume 217: Issue 1
Open access
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