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Daniel Cuevas-Ramos Department of Medicine, Neuroendocrinology Clinic, Departments of Medicine and Neurological Surgery, Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, California, USA
Department of Medicine, Neuroendocrinology Clinic, Departments of Medicine and Neurological Surgery, Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, California, USA

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Maria Fleseriu Department of Medicine, Neuroendocrinology Clinic, Departments of Medicine and Neurological Surgery, Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, California, USA

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Introduction Cushing's disease (CD) is caused by an adrenocorticotropin (ACTH)-secreting pituitary tumor that stimulates cortisol production by the adrenal glands. Morbidity and mortality are significantly increased if hypercortisolemia is left

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0300
Volume/Issue:
Volume 223: Issue 2
Free access
Anna H Kongsted
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Sanne V Husted
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Malin P Thygesen Department of Veterinary Clinical and Animal Sciences, Cook Medical Europe APS, School of Animal Biology, Department of Basic Sciences and Environment, Department of Animal Science, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Vibeke G Christensen
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Dominique Blache Department of Veterinary Clinical and Animal Sciences, Cook Medical Europe APS, School of Animal Biology, Department of Basic Sciences and Environment, Department of Animal Science, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Anders Tolver Department of Veterinary Clinical and Animal Sciences, Cook Medical Europe APS, School of Animal Biology, Department of Basic Sciences and Environment, Department of Animal Science, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Torben Larsen Department of Veterinary Clinical and Animal Sciences, Cook Medical Europe APS, School of Animal Biology, Department of Basic Sciences and Environment, Department of Animal Science, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Bjørn Quistorff Department of Veterinary Clinical and Animal Sciences, Cook Medical Europe APS, School of Animal Biology, Department of Basic Sciences and Environment, Department of Animal Science, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Mette O Nielsen
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concentrations of the hormones insulin, growth hormone (GH), insulin-like growth factor 1 (IGF1), cortisol and leptin were measured only in samples obtained at 0, 44 and 48 h from the 6-month-old fasted adolescent lambs (except that of cortisol due to lack of a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0099
Volume/Issue:
Volume 219: Issue 2
Free access
Peter J Fuller Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research and the Monash University Department of Molecular Translational Science, Clayton, Victoria, Australia

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Jun Yang Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research and the Monash University Department of Molecular Translational Science, Clayton, Victoria, Australia

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Morag J Young Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research and the Monash University Department of Molecular Translational Science, Clayton, Victoria, Australia

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domains, and the cloned MR was used in ‘cis-trans’ assays to provide functional characterization of the receptor including its ability to bind both aldosterone and cortisol ( Evans & Arriza 1989 ). These transcription factors enhanced gene expression in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0060
Volume/Issue:
Volume 234: Issue 1
Free access
Seth A Reini Department of Pharmacodynamics, Department of Physiology and Functional Genomics, College of Pharmacy, University of Florida, Box 100487, Gainesville, Florida 32610-0487, USA

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Garima Dutta
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Charles E Wood Department of Pharmacodynamics, Department of Physiology and Functional Genomics, College of Pharmacy, University of Florida, Box 100487, Gainesville, Florida 32610-0487, USA

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Maureen Keller-Wood
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Introduction In late gestation, normal fetal growth and fetal cardiovascular homeostasis is dependent on the proper regulation of maternal cortisol levels. Although reductions in maternal cortisol prevent the normal increases in maternal plasma

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0022
Volume/Issue:
Volume 198: Issue 2
Free access
Jun Yang Centre of Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Medicine, Monash University, Clayton, Victoria, Australia

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Morag J Young Cardiovascular Endocrinology Laboratory, Discovery & Preclinical Domain, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Timothy J Cole Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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Peter J Fuller Centre of Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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et al. 2005 ). The MR is unique in having two physiological agonist ligands, aldosterone and cortisol (corticosterone in rodents). However, they are not equivalent in that each induces subtly different conformations in the LBD with functional

Article Type:
Review Article
Collections:
Endocrine Society of Australia special collection
DOI:
https://doi.org/10.1530/JOE-22-0249
Volume/Issue:
Volume 259: Issue 1
Free access
Jordan E Hamden Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada

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Melody Salehzadeh Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada

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Katherine M Gray Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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Brandon J Forys Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada

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Kiran K Soma Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Graduate Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada

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. The limit of detection for progesterone, 11-deoxycorticosterone (DOC), corticosterone, DHC, 11-deoxycortisol, cortisol, and cortisone was improved four-fold, from 0.2 to 0.05 pg. Standard curves, controls, blanks (solvent with deuterated internal

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0154
Volume/Issue:
Volume 251: Issue 2
Restricted access
Barry N Madison Department of Integrative Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario, Canada N1G 2W1

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Sara Tavakoli Department of Integrative Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario, Canada N1G 2W1

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Sarah Kramer Department of Integrative Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario, Canada N1G 2W1

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Nicholas J Bernier Department of Integrative Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario, Canada N1G 2W1

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activate the hypothalamic–pituitary–interrenal axis and as a result are associated with an increase in the circulating levels of the primary glucocorticoid in teleosts fish, cortisol ( Wendelaar Bonga 1997 , Bernier et al . 2009 ). Since glucocorticoids

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0186
Volume/Issue:
Volume 226: Issue 2
Free access
Toshio Shimada Department of Physiology, Nagasaki University School of Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto-machi, Nagasaki 852-8523, Japan

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Taeko Hirose Department of Physiology, Nagasaki University School of Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto-machi, Nagasaki 852-8523, Japan

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Itsuro Matsumoto Department of Physiology, Nagasaki University School of Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto-machi, Nagasaki 852-8523, Japan

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Tadaomi Aikawa Department of Physiology, Nagasaki University School of Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto-machi, Nagasaki 852-8523, Japan

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). By contrast, cortisol secretion in response to a second infusion of PAF was diminished ( Shimada et al. 2005 ). Thus, PAF desensitizes steroidogenesis in a homologous manner through its own ligand. The mechanism of such receptor-specific homologous

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0251
Volume/Issue:
Volume 195: Issue 1
Free access
R Ganga Grupo de Investigación en Acuicultura, Instituto Canario de Ciencias Marinas, PO Box 56, 35200-Telde, Las Palmas, Canary Islands, Spain
Department of Cell Biology, Physiology and Immunology, Universitat Autonòma de Barcelona, Bellaterra 08193, Spain

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L Tort Grupo de Investigación en Acuicultura, Instituto Canario de Ciencias Marinas, PO Box 56, 35200-Telde, Las Palmas, Canary Islands, Spain
Department of Cell Biology, Physiology and Immunology, Universitat Autonòma de Barcelona, Bellaterra 08193, Spain

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L Acerete Grupo de Investigación en Acuicultura, Instituto Canario de Ciencias Marinas, PO Box 56, 35200-Telde, Las Palmas, Canary Islands, Spain
Department of Cell Biology, Physiology and Immunology, Universitat Autonòma de Barcelona, Bellaterra 08193, Spain

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D Montero Grupo de Investigación en Acuicultura, Instituto Canario de Ciencias Marinas, PO Box 56, 35200-Telde, Las Palmas, Canary Islands, Spain
Department of Cell Biology, Physiology and Immunology, Universitat Autonòma de Barcelona, Bellaterra 08193, Spain

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M S Izquierdo Grupo de Investigación en Acuicultura, Instituto Canario de Ciencias Marinas, PO Box 56, 35200-Telde, Las Palmas, Canary Islands, Spain
Department of Cell Biology, Physiology and Immunology, Universitat Autonòma de Barcelona, Bellaterra 08193, Spain

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( Izquierdo 1996 ), raised the basal plasma cortisol levels and altered the pattern of cortisol release after stress ( Montero et al. 1998 ). Cortisol is a key corticosteroid hormone for homeostatic response to stress in all vertebrates, through its effects

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06770
Volume/Issue:
Volume 190: Issue 1
Free access
Silvia Begliuomini
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Elena Lenzi
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Filippo Ninni
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Elena Casarosa
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Sara Merlini
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Nicola Pluchino
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Valeria Valentino
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Stefano Luisi Division of Gynecology and Obstetrics, Division of Obstetrics and Gynecology, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa 56100, Italy

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Michele Luisi
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Andrea R Genazzani
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, we looked for a possible interplay between BDNF and cortisol, the circadian physiological rhythm of which is well recognized in human plasma, with a zenith in the morning and a large decrease during the day. For this purpose, we studied whether there

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0376
Volume/Issue:
Volume 197: Issue 2
Free access