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Department of Cellular and Integrative Physiology, Section of Nephrology, Department of Internal Medicine, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, Nebraska 68198-5850, USA
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with WT mice on high-fat diet ( n =7–8). Basal metabolic rate and energy expenditure are decreased in Parp -KO mice. (B) Comparison of the oxygen consumption for a period of 24 h for WT and Parp -KO mice that were fed HF diet for 19 weeks. (C
Department of Translational Medicine, EPM, Federal University of Sao Paulo, Sao Paulo, SP, Brazil
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Department of Translational Medicine, EPM, Federal University of Sao Paulo, Sao Paulo, SP, Brazil
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Introduction A balance between food intake and energy expenditure is essential to preserve fuel homeostasis. Changes in caloric intake trigger physiological responses that include adaptive modifications in appetite, metabolic rate and energy
Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil
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Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil
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period, animals were studied for resting metabolic rate (RMR), glucose tolerance test (GTT), and insulin tolerance test (ITT). Animals were subsequently killed by exsanguinations under urethane anesthesia, and blood processed for plasma isolation and
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Department of Minimally Invasive Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
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Department of Nutrition, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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KIIT School of Biotechnology, KIIT University, Bhubaneswar, India
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treated mice. Metabolic rate was calculated based on rate of oxygen consumption measured in the acclimated, individually housed mice for 24 h at an ambient temperature (RT) and after 6 h cold-exposure in metabolic cages. The basal metabolic rate was
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Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil
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Introduction Compound 3,3′,5-triiodothyronine (T 3 ) exerts many important effects on the basal metabolic rate and increases oxygen consumption. Several years ago, it was shown that 3,5-diiodothyronine (3,5-T2) is responsible for certain non
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Institute of Medical Science, Department of Psychology, University of Toronto, Toronto, Ontario, Canada M5S 3G3
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have marked increases in diaphorase staining of muscle fibers, suggestive of hypermetabolism ( Monks et al . 2007 ). Indeed, HSA-AR rats exhibit increased resting metabolic rate (RMR) as well as increased electron transport chain (ETC) activity within
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increased metabolic rate, increased locomotor activity or both ( Shimada et al. 1998 , Segal-Lieberman et al. 2003 ). MCH is expressed in the central nervous system (CNS), primarily in the rostral zona incerta/incerto-hypothalamic and the lateral
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expenditure, with the latter comprised of basal metabolic rate, physical activity and adaptive thermogenesis. Adaptive thermogenesis is defined as specialised heat production and occurs in BAT and skeletal muscle. Cold- and meal-associated stimuli are
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metabolic rate ( Baskin et al . 1999 , Cone et al . 2001 ). This occurs principally via the action of α-melanocyte-stimulating hormone (α-MSH), a peptide derived from the proopiomelanocortin (POMC)-expressing neurons in the hypothalamus and brainstem
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Although 1-methyl-2-mercaptoimidazole (Methimazole) has been shown to be more potent than thiouracil in controlling the clinical symptoms of hyperthyroidism (Stanley & Astwood, 1949), little has been published about its effects on normal laboratory animals. It seemed of interest therefore to report results obtained from the use of this substance in the course of experiments for which groups of rats with altered metabolic rates were required. The metabolic rate was raised by administration of triiodothyronine.
EXPERIMENTAL METHODS AND RESULTS
For measurement of metabolic rate, a closed circuit system was used, air being circulated by motor-driven bellows. The animals were contained in four cylindrical glass chambers immersed in a constant temperature water bath. CO2 was absorbed on soda lime and the amount of oxygen consumed measured by specially constructed Krogh-type spirometers, filled with water at the same temperature as that in the main water bath. Each chamber was capable of holding