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A Iida-Klein
A Iida-Klein
Regional Bone and
Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
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Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
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S Shou Lu
S Shou Lu
Regional Bone and
Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
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Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
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R Kapadia
R Kapadia
Regional Bone and
Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
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Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
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M Burkhart
M Burkhart
Regional Bone and
Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
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Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
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A Moreno
A Moreno
Regional Bone and
Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
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Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
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D W Dempster
D W Dempster
Regional Bone and
Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
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Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
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R Lindsay
R Lindsay
Regional Bone and
Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
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Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
Scanco USA Inc., Wayne, Pennsylvania, USA
Departments of Clinical Pathology and
Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
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Parathyroid hormone (PTH) stimulates bone resorption as well as bone formation in vivo and in organ culture. The catabolic actions of PTH have been recognized in patients with hyperparathyroidism, or with acute infusion of the N-terminal 1–34 fragment of human PTH (hPTH1–34). Whereas the anabolic actions of daily injection with PTH have been well studied in both humans and mice, the catabolic actions of PTH on murine bone remain to be defined. To do this we sought to create a model with short-term, sustained hyperparathyroidism using osmotic infusion pumps. We treated 10-week-old female C57BL/J6 mice with continuous infusion of hPTH1–34 (8.1 pmol/0.25 μl per h, equivalent to 40 μg/kg per day) or vehicle for 2 weeks, using Alzet osmotic pumps. Bone mineral density (BMD), serum total calcium, hPTH1–34, mouse intact PTH (mPTH1–84), osteocalcin and mouse tartrate-resistant acid phosphatase (mTRAP) activity, and microarchitectural variables of the distal femur were measured. Separately, we compared the effects of intermittent daily injection of hPTH1–34 (40 μg/kg per day) with continuous infusion of hPTH1–34 on BMD and bone markers. Exogenous hPTH1–34 was detected only in the PTH-infused mice. Both intermittent and continuous treatment with hPTH1–34 markedly suppressed endogenous mPTH1–84, but only the latter induced hypercalcemia. Daily PTH injection significantly increased both serum osteocalcin and mTRAP, while continuous PTH infusion showed a strong trend to stimulate mTRAP, with a slight but non-significant increase in osteocalcin. There were significant differences in BMD at all sites between animals treated with the same daily dose of intermittent and continuous hPTH1–34. Microcomputed tomography (μCT) analysis of the distal femurs revealed that hPTH1–34 infusion significantly decreased trabecular connectivity density (P<0.05). Thus, the murine bone response to continuous PTH infusion was quite different from that seen with daily PTH injection. Short-term infusion of hPTH1–34 appears to be a good model to study the mechanisms underlying the catabolic action of PTH in mice.
K L Gustafsson
K L Gustafsson
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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K H Nilsson
K H Nilsson
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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H H Farman
H H Farman
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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A Andersson
A Andersson
Center for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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V Lionikaite
V Lionikaite
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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P Henning
P Henning
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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J Wu
J Wu
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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S H Windahl
S H Windahl
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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U Islander
U Islander
Center for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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S Movérare-Skrtic
S Movérare-Skrtic
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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K Sjögren
K Sjögren
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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H Carlsten
H Carlsten
Center for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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J-Å Gustafsson
J-Å Gustafsson
Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
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C Ohlsson
C Ohlsson
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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M K Lagerquist
M K Lagerquist
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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-resolution microcomputed tomography High-resolution microcomputed tomography (μCT) analysis was performed on the vertebrae L 5 and femur using an 1172 model μCT (Bruker MicroCT, Aartselaar, Belgium) as previously described ( Moverare-Skrtic et al . 2014 ). The
Karin L Gustafsson
Karin L Gustafsson
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Sofia Movérare-Skrtic
Sofia Movérare-Skrtic
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Helen H Farman
Helen H Farman
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Cecilia Engdahl
Cecilia Engdahl
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Petra Henning
Petra Henning
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Karin H Nilsson
Karin H Nilsson
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Julia M Scheffler
Julia M Scheffler
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Edina Sehic
Edina Sehic
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Ulrika Islander
Ulrika Islander
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Ellis Levin
Ellis Levin
Division of Endocrinology, Department of Medicine, University of California, Irvine, Irvine, California, USA
Department of Veterans Affairs Medical Center, Long Beach, Long Beach, California, USA
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Department of Veterans Affairs Medical Center, Long Beach, Long Beach, California, USA
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Claes Ohlsson
Claes Ohlsson
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Drug Treatment, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden
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Department of Drug Treatment, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden
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Marie K Lagerquist
Marie K Lagerquist
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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bone parameters Dual-energy X-ray absorptiometry Analyses of total body areal bone mineral density (aBMD) were performed using a Lunar PIXImus mouse densitometer (Wipro GE Healthcare). High-resolution microcomputed tomography High
Kenneth A Philbrick
Kenneth A Philbrick
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Carmen P Wong
Carmen P Wong
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Adam J Branscum
Adam J Branscum
Biostatistics Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Russell T Turner
Russell T Turner
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Urszula T Iwaniec
Urszula T Iwaniec
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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weighed. Femora were removed, fixed for 24 h in 10% buffered formalin and stored in 70% ethanol for microcomputed tomography and histomorphometric analysis. Tibiae and hypothalami were removed, frozen in liquid nitrogen and stored at −80°C for mRNA
Russell T Turner
Russell T Turner
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Kenneth A Philbrick
Kenneth A Philbrick
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Carmen P Wong
Carmen P Wong
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Adam J Branscum
Adam J Branscum
Biostatistics Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Urszula T Iwaniec
Urszula T Iwaniec
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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of bone turnover. Uteri and abdominal WAT were excised and weighed. Femora and fifth lumbar vertebrae were collected, stored in 70% ethanol and evaluated using dual-energy x-ray absorptiometry (DXA) and microcomputed tomography (μCT). Serum
Vikte Lionikaite
Vikte Lionikaite
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Karin L Gustafsson
Karin L Gustafsson
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Anna Westerlund
Anna Westerlund
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Sara H Windahl
Sara H Windahl
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Antti Koskela
Antti Koskela
Department of Anatomy and Cell Biology, Medical Research Center, University of Oulu, Oulu, Finland
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Juha Tuukkanen
Juha Tuukkanen
Department of Anatomy and Cell Biology, Medical Research Center, University of Oulu, Oulu, Finland
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Helena Johansson
Helena Johansson
Institute for Health and Aging, Catholic University of Australia, Melbourne, Australia
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Claes Ohlsson
Claes Ohlsson
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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H Herschel Conaway
H Herschel Conaway
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Petra Henning
Petra Henning
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Ulf H Lerner
Ulf H Lerner
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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in all analyses. Data are displayed as fold change relative to control. Assessment of bone parameters Peripheral quantitative computed tomography (pQCT) and microcomputed tomography (µCT) Peripheral quantitative computed tomography (pQCT
K David
K David
Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
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Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
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V Dubois
V Dubois
Basic and Translational Endocrinology, Department of Basic and Applied Medical Sciences, UGent, Ghent, Belgium
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A Verhulst
A Verhulst
Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
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V Sommers
V Sommers
Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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D Schollaert
D Schollaert
Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven
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L Deboel
L Deboel
Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven
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K Moermans
K Moermans
Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven
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G Carmeliet
G Carmeliet
Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven
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P D’Haese
P D’Haese
Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
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D Vanderschueren
D Vanderschueren
Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
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Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
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F Claessens
F Claessens
Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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P Evenepoel
P Evenepoel
Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
Department of Nephrology, University Hospitals Leuven, Leuven, Belgium
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Department of Nephrology, University Hospitals Leuven, Leuven, Belgium
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B Decallonne
B Decallonne
Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
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Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
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. Testosterone levels were analyzed via LC-MS/MS ( Antonio et al. 2018 ). Luteinizing hormone (LH) levels were determined by ultrasensitive ELISA ( Steyn et al. 2013 ). Microcomputed tomography L5 vertebral bodies and right tibiae were scanned ex
Guillaume Mabilleau
Guillaume Mabilleau
Groupe d’Etudes Remodelage Osseux et bioMatériaux, GEROM, SFR 42-08, Université d’Angers, IRIS-IBS Institut de Biologie en Santé, CHU d’Angers, Angers Cedex, France
Bone Pathology Unit, Angers University Hospital, Angers Cedex, France
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Bone Pathology Unit, Angers University Hospital, Angers Cedex, France
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Benoit Gobron
Benoit Gobron
Groupe d’Etudes Remodelage Osseux et bioMatériaux, GEROM, SFR 42-08, Université d’Angers, IRIS-IBS Institut de Biologie en Santé, CHU d’Angers, Angers Cedex, France
Rheumatology Department, Angers University Hospital, Angers Cedex, France
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Rheumatology Department, Angers University Hospital, Angers Cedex, France
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Aleksandra Mieczkowska
Aleksandra Mieczkowska
Groupe d’Etudes Remodelage Osseux et bioMatériaux, GEROM, SFR 42-08, Université d’Angers, IRIS-IBS Institut de Biologie en Santé, CHU d’Angers, Angers Cedex, France
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Rodolphe Perrot
Rodolphe Perrot
Service Commun d’Imageries et d’Analyses Microscopiques, SCIAM, SFR 42-08, Université d’Angers, IRIS-IBS Institut de Biologie en Santé, CHU d’Angers, Angers Cedex, France
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Daniel Chappard
Daniel Chappard
Groupe d’Etudes Remodelage Osseux et bioMatériaux, GEROM, SFR 42-08, Université d’Angers, IRIS-IBS Institut de Biologie en Santé, CHU d’Angers, Angers Cedex, France
Bone Pathology Unit, Angers University Hospital, Angers Cedex, France
Service Commun d’Imageries et d’Analyses Microscopiques, SCIAM, SFR 42-08, Université d’Angers, IRIS-IBS Institut de Biologie en Santé, CHU d’Angers, Angers Cedex, France
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Bone Pathology Unit, Angers University Hospital, Angers Cedex, France
Service Commun d’Imageries et d’Analyses Microscopiques, SCIAM, SFR 42-08, Université d’Angers, IRIS-IBS Institut de Biologie en Santé, CHU d’Angers, Angers Cedex, France
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to the manufacturer recommendations. Microcomputed tomography X-ray microcomputed tomography (MicroCT) analyses of the abdomen were performed to measure abdominal fat volume, that represents a good indicator of whole-body fat mass ( Judex et
Iris Boraschi-Diaz
Iris Boraschi-Diaz
Shriners Hospital for Children-Canada, Montreal, Quebec, Canada
Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
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Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
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Josephine T Tauer
Josephine T Tauer
Shriners Hospital for Children-Canada, Montreal, Quebec, Canada
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Omar El-Rifai
Omar El-Rifai
Unité de Recherche en Physiologie Intégrative et Moléculaire, Institut de Recherches Cliniques de Montréal, Montréal, Québec, Canada
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Delphine Guillemette
Delphine Guillemette
Shriners Hospital for Children-Canada, Montreal, Quebec, Canada
Département de Mathématiques, Université du Québec à Montréal, Montréal, Québec, Canada
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Département de Mathématiques, Université du Québec à Montréal, Montréal, Québec, Canada
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Geneviève Lefebvre
Geneviève Lefebvre
Département de Mathématiques, Université du Québec à Montréal, Montréal, Québec, Canada
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Frank Rauch
Frank Rauch
Shriners Hospital for Children-Canada, Montreal, Quebec, Canada
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Mathieu Ferron
Mathieu Ferron
Unité de Recherche en Physiologie Intégrative et Moléculaire, Institut de Recherches Cliniques de Montréal, Montréal, Québec, Canada
Départements de Médecine et de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, Québec, Canada
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Départements de Médecine et de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, Québec, Canada
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Svetlana V Komarova
Svetlana V Komarova
Shriners Hospital for Children-Canada, Montreal, Quebec, Canada
Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
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Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
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EchoMRI model ET-040, version 11,06,22 (EchoMRI LLC). Microcomputed tomography (micro CT) It was performed on right femurs of 4-week-old mice using Skyscan 1272 at a voxel size of 5 μm. Scan parameters included a 0.40-degree increment angle, 3 frames
Muneaki Ishijima
Muneaki Ishijima
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10, Kanda-Surugadai 2-Chome, Chiyoda-Ku, Tokyo 101-0062, Japan
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Kunikazu Tsuji
Kunikazu Tsuji
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10, Kanda-Surugadai 2-Chome, Chiyoda-Ku, Tokyo 101-0062, Japan
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Susan R Rittling
Susan R Rittling
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10, Kanda-Surugadai 2-Chome, Chiyoda-Ku, Tokyo 101-0062, Japan
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Teruhito Yamashita
Teruhito Yamashita
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10, Kanda-Surugadai 2-Chome, Chiyoda-Ku, Tokyo 101-0062, Japan
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Hisashi Kurosawa
Hisashi Kurosawa
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10, Kanda-Surugadai 2-Chome, Chiyoda-Ku, Tokyo 101-0062, Japan
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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David T Denhardt
David T Denhardt
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10, Kanda-Surugadai 2-Chome, Chiyoda-Ku, Tokyo 101-0062, Japan
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Akira Nifuji
Akira Nifuji
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10, Kanda-Surugadai 2-Chome, Chiyoda-Ku, Tokyo 101-0062, Japan
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Yoichi Ezura
Yoichi Ezura
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10, Kanda-Surugadai 2-Chome, Chiyoda-Ku, Tokyo 101-0062, Japan
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Masaki Noda
Masaki Noda
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10, Kanda-Surugadai 2-Chome, Chiyoda-Ku, Tokyo 101-0062, Japan
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Department of Orthopaedics, School of Medicine, Juntendo University, Tokyo 113-8421, Japan
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. Fractional trabecular bone volume (BV/TV) was quantified based on the image of microcomputed tomography (μCT) pictures of the tibiae after 1 week of either tail suspension (Susp) or loading (Load) in wild-type (wild-type) or OPN−/− mice (OPN−/−). Data are
