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Roza Benabdesselam Unité de Recherches, Laboratoire de Neurochimie/LBPO, INSERM UMRS‐592, UPMC University Paris 06, INSERM U952, CNRS UMR 7224, Faculté des Sciences Biologiques/UMMTO, BP 17, Tizi-Ouzou, Algeria
Unité de Recherches, Laboratoire de Neurochimie/LBPO, INSERM UMRS‐592, UPMC University Paris 06, INSERM U952, CNRS UMR 7224, Faculté des Sciences Biologiques/UMMTO, BP 17, Tizi-Ouzou, Algeria

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Latifa Dorbani-Mamine Unité de Recherches, Laboratoire de Neurochimie/LBPO, INSERM UMRS‐592, UPMC University Paris 06, INSERM U952, CNRS UMR 7224, Faculté des Sciences Biologiques/UMMTO, BP 17, Tizi-Ouzou, Algeria

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Ouahiba Benmessaoud-Mesbah Unité de Recherches, Laboratoire de Neurochimie/LBPO, INSERM UMRS‐592, UPMC University Paris 06, INSERM U952, CNRS UMR 7224, Faculté des Sciences Biologiques/UMMTO, BP 17, Tizi-Ouzou, Algeria

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Alvaro Rendon Unité de Recherches, Laboratoire de Neurochimie/LBPO, INSERM UMRS‐592, UPMC University Paris 06, INSERM U952, CNRS UMR 7224, Faculté des Sciences Biologiques/UMMTO, BP 17, Tizi-Ouzou, Algeria

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Sakina Mhaouty-Kodja Unité de Recherches, Laboratoire de Neurochimie/LBPO, INSERM UMRS‐592, UPMC University Paris 06, INSERM U952, CNRS UMR 7224, Faculté des Sciences Biologiques/UMMTO, BP 17, Tizi-Ouzou, Algeria
Unité de Recherches, Laboratoire de Neurochimie/LBPO, INSERM UMRS‐592, UPMC University Paris 06, INSERM U952, CNRS UMR 7224, Faculté des Sciences Biologiques/UMMTO, BP 17, Tizi-Ouzou, Algeria
Unité de Recherches, Laboratoire de Neurochimie/LBPO, INSERM UMRS‐592, UPMC University Paris 06, INSERM U952, CNRS UMR 7224, Faculté des Sciences Biologiques/UMMTO, BP 17, Tizi-Ouzou, Algeria

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Hélène Hardin-Pouzet Unité de Recherches, Laboratoire de Neurochimie/LBPO, INSERM UMRS‐592, UPMC University Paris 06, INSERM U952, CNRS UMR 7224, Faculté des Sciences Biologiques/UMMTO, BP 17, Tizi-Ouzou, Algeria
Unité de Recherches, Laboratoire de Neurochimie/LBPO, INSERM UMRS‐592, UPMC University Paris 06, INSERM U952, CNRS UMR 7224, Faculté des Sciences Biologiques/UMMTO, BP 17, Tizi-Ouzou, Algeria
Unité de Recherches, Laboratoire de Neurochimie/LBPO, INSERM UMRS‐592, UPMC University Paris 06, INSERM U952, CNRS UMR 7224, Faculté des Sciences Biologiques/UMMTO, BP 17, Tizi-Ouzou, Algeria

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the antidiuretic hormone vasopressin (arginine vasopressin (AVP)) into the blood stream ( Antunes-Rodrigues et al . 2004 ). In Dp71-null mice, we described compensatory ectopic expression of DP140 in the magnocellular neurons of the hypothalamus. To

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Jessica L Huang Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, Davis, California, USA

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Sharon Lee Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, Davis, California, USA

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Pelle Hoek Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, Davis, California, USA

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Talitha van der Meulen Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, Davis, California, USA

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Richard Van Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, Davis, California, USA

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Mark O Huising Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, Davis, California, USA
Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, California, USA

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were maintained in group housing on a 12 h light:12 h darkness cycle with free access to water and standard rodent chow. Ucn3 -null mice were described previously ( Li et al. 2007 ). For all experiments, mice heterozygous for the Ucn3 -null allele

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Laurie K Bale Endocrine Research Unit, Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic College of Medicine, 200 First Street SW, 5-194 Joseph, Rochester, Minnesota 55905, USA

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Cheryl A Conover Endocrine Research Unit, Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic College of Medicine, 200 First Street SW, 5-194 Joseph, Rochester, Minnesota 55905, USA

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times through regulated expression of PAPP-A and its associated proteolytic activity ( Pintar et al. 1998 ). Recently, we generated PAPP-A-null mice which, similar to IGF-II-null mice, were born as proportional dwarfs ( Conover et al. 2004 ). The

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J C Sousa Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
Institute for Molecular and Cell Biology, Rua do Campo Alegre, Porto, Portugal
ICBAS, University of Porto, Largo Professor Abel Salazar, Porto, Portugal
Molecular Endocrinology Unit, Instituto de Investigaciones Biomédicas Alberto Sols, CSIC & UAM, Madrid, Spain
Department of Production & Systems Engineering, University of Minho, Campus Gualtar, Braga, Portugal

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G Morreale de Escobar Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
Institute for Molecular and Cell Biology, Rua do Campo Alegre, Porto, Portugal
ICBAS, University of Porto, Largo Professor Abel Salazar, Porto, Portugal
Molecular Endocrinology Unit, Instituto de Investigaciones Biomédicas Alberto Sols, CSIC & UAM, Madrid, Spain
Department of Production & Systems Engineering, University of Minho, Campus Gualtar, Braga, Portugal

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P Oliveira Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
Institute for Molecular and Cell Biology, Rua do Campo Alegre, Porto, Portugal
ICBAS, University of Porto, Largo Professor Abel Salazar, Porto, Portugal
Molecular Endocrinology Unit, Instituto de Investigaciones Biomédicas Alberto Sols, CSIC & UAM, Madrid, Spain
Department of Production & Systems Engineering, University of Minho, Campus Gualtar, Braga, Portugal

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M J Saraiva Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
Institute for Molecular and Cell Biology, Rua do Campo Alegre, Porto, Portugal
ICBAS, University of Porto, Largo Professor Abel Salazar, Porto, Portugal
Molecular Endocrinology Unit, Instituto de Investigaciones Biomédicas Alberto Sols, CSIC & UAM, Madrid, Spain
Department of Production & Systems Engineering, University of Minho, Campus Gualtar, Braga, Portugal

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J A Palha Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
Institute for Molecular and Cell Biology, Rua do Campo Alegre, Porto, Portugal
ICBAS, University of Porto, Largo Professor Abel Salazar, Porto, Portugal
Molecular Endocrinology Unit, Instituto de Investigaciones Biomédicas Alberto Sols, CSIC & UAM, Madrid, Spain
Department of Production & Systems Engineering, University of Minho, Campus Gualtar, Braga, Portugal

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thyroid hormone homeostasis, we challenged TTR-null mice to cold exposure and removal of the thyroid gland, conditions of moderate and extremely increased hormone demand respectively. Materials and Methods Animals

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Abdoulaye Diané Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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Nikolina Nikolic Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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Alexander P Rudecki Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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Shannon M King Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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Drew J Bowie Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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Sarah L Gray Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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supported by the temperature-sensitive phenotype of Pacap null pups, which display reduced survival at a lower housing temperature ( Gray et al . 2002 ); however, the underlying mechanisms by which Pacap null mice are cold intolerant remain unknown. A

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Stefano Zanotti Department of Research, The University of Connecticut School of Medicine, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105-1299, USA

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Lisa Stadmeyer Department of Research, The University of Connecticut School of Medicine, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105-1299, USA

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Anna Smerdel-Ramoya Department of Research, The University of Connecticut School of Medicine, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105-1299, USA

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Deena Durant Department of Research, The University of Connecticut School of Medicine, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105-1299, USA

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Ernesto Canalis Department of Research, The University of Connecticut School of Medicine, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105-1299, USA
Department of Research, The University of Connecticut School of Medicine, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105-1299, USA

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region of the osteocalcin gene. Cebpb null mutant mice are viable, possibly because of partial rescue from other members of the C/EBP family, or because C/EBPβ is dispensable during development. Cebpb null mice are affected by a lymphoproliferative

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Juan Kong Laboratory of Metabolic Disease Research and Drug Development, Division of Biological Sciences, Ministry of Health Key Laboratory of Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang, People's Republic of China
Laboratory of Metabolic Disease Research and Drug Development, Division of Biological Sciences, Ministry of Health Key Laboratory of Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang, People's Republic of China

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Yunzi Chen Laboratory of Metabolic Disease Research and Drug Development, Division of Biological Sciences, Ministry of Health Key Laboratory of Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang, People's Republic of China
Laboratory of Metabolic Disease Research and Drug Development, Division of Biological Sciences, Ministry of Health Key Laboratory of Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang, People's Republic of China

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Guojun Zhu Laboratory of Metabolic Disease Research and Drug Development, Division of Biological Sciences, Ministry of Health Key Laboratory of Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang, People's Republic of China

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Qun Zhao Laboratory of Metabolic Disease Research and Drug Development, Division of Biological Sciences, Ministry of Health Key Laboratory of Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang, People's Republic of China

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Yan Chun Li Laboratory of Metabolic Disease Research and Drug Development, Division of Biological Sciences, Ministry of Health Key Laboratory of Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang, People's Republic of China
Laboratory of Metabolic Disease Research and Drug Development, Division of Biological Sciences, Ministry of Health Key Laboratory of Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang, People's Republic of China

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role for the VDR in the regulation of adipogenesis and energy metabolism. 1,25(OH) 2 D 3 suppresses 3T3-L1 preadipocyte differentiation into mature adipocytes ( Blumberg et al . 2006 , Kong & Li 2006 ). Global VDR-null mice exhibit a lean phenotype

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Jennifer H Steel Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Du Cane Road, London W12 0NN, UK

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Roger White Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Du Cane Road, London W12 0NN, UK

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Malcolm G Parker Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Du Cane Road, London W12 0NN, UK

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initial failure of oocyte release did not affect luteinization and production of progesterone in the early stages of pregnancy, the normal mid-gestation rise in progesterone levels was not as pronounced in embryo-transferred RIP140-null mice. This is

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Morag J Young Cardiovascular Endocrinology, Department of Physiology, MIMR-PHI Institute, 27–31 Wright St, Clayton 3168, Australia
Cardiovascular Endocrinology, Department of Physiology, MIMR-PHI Institute, 27–31 Wright St, Clayton 3168, Australia

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Amanda J Rickard Cardiovascular Endocrinology, Department of Physiology, MIMR-PHI Institute, 27–31 Wright St, Clayton 3168, Australia
Cardiovascular Endocrinology, Department of Physiology, MIMR-PHI Institute, 27–31 Wright St, Clayton 3168, Australia

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MR ( McGraw et al . 2013 ). Aldosterone significantly increases the development of early atherosclerotic changes in the aorta as well as increasing the degree of inflammation of plaques in Apoe -null mice. The authors identified placental growth

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Cecilia Brännmark Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Emma I Kay Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

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Unn Örtegren Kugelberg Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

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Belén Chanclón Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Man Mohan Shrestha Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Ingrid Wernstedt Asterholm Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Peter Strålfors Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

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Charlotta S Olofsson Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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al. 2004 , Lang 2007 ), such as caveolae. Cav1 null mice exhibit decreased circulating levels of adiponectin as well as adipose tissue metabolic and mitochondrial dysfunction. Interestingly, the HMW form of adiponectin was specifically reduced in

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