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Harleen Kaur Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia

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Beverly S Muhlhausler Food and Nutrition Research Group, School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, Australia
Nutrition and Health Program, Health and Biosecurity Business Unit, Commonwealth Scientific and Industrial Research Organisation, Adelaide, Australia

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Pamela Su-Lin Sim Food and Nutrition Research Group, School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, Australia

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Amanda J Page Adelaide Medical School, The University of Adelaide, Adelaide, Australia
Nutrition, Diabetes & Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia

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Hui Li Adelaide Medical School, The University of Adelaide, Adelaide, Australia
Nutrition, Diabetes & Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia

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Maria Nunez-Salces Adelaide Medical School, The University of Adelaide, Adelaide, Australia
Nutrition, Diabetes & Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia

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Georgia S Clarke Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia
Nutrition, Diabetes & Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia

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Lili Huang School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Rebecca L Wilson Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia

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Johannes D Veldhuis Endocrine Research Unit, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota, USA

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Chen Chen School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Claire T Roberts Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia

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Kathryn L Gatford Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia

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Introduction Successful pregnancy requires substantial maternal physiological adaptations, including increases in food intake, to maintain maternal health and allow optimal growth of the feto-placental unit to term. Growth hormone (GH) is a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0072
Volume/Issue:
Volume 245: Issue 2
Restricted access
Hui Yu Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Zoe Thompson Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Sylee Kiran Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA
School of Literature, Science, and Arts, University of Michigan, Ann Arbor, Michigan, USA

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Graham L Jones Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan, USA

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Lakshmi Mundada Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Surbhi Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Marcelo Rubinstein Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas and Facultad de Ciencias Exactas y Naturales, Universidad de Buenos, Buenos Aires, Argentina

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Malcolm J Low Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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). LEPRE might buffer leptin signaling by reducing its renal clearance under normal physiological conditions and prevent excessive binding of elevated circulating leptin to LEPRB in extreme metabolic conditions, such as late pregnancy ( Tu et al . 2008

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0576
Volume/Issue:
Volume 245: Issue 1
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Sian J S Simpson Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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Lorna I F Smith Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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Peter M Jones Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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James E Bowe Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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. There is some evidence that placentally derived CRH and urocortins are involved in various biological functions associated with pregnancy ( Thomson 2013 , You et al . 2014 ). Thus, pregnancy represents one possible physiological state in which the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0568
Volume/Issue:
Volume 245: Issue 2
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Pierre Hofstee School of Medical Science, Griffith University Gold Coast Campus, Southport

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Janelle James-McAlpine School of Medical Science, Griffith University Gold Coast Campus, Southport
School of Nursing and Midwifery, Griffith University, Meadowbrook, Queensland, Australia

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Daniel R McKeating School of Medical Science, Griffith University Gold Coast Campus, Southport

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Jessica J Vanderlelie The Judith Lumley Centre, La Trobe University, Bundoora, Victoria, Australia

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James S M Cuffe The School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia

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Anthony V Perkins The School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia

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18% of women presenting as thyroid antibody positive in their first trimester of pregnancy ( Forehan 2012 ). Thyroid dysfunction has been shown to increase the risk of adverse maternal and fetal outcomes ( Nazarpour et al. 2015 ). The most abundant

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0319
Volume/Issue:
Volume 248: Issue 1
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Jackson Nteeba Department of Pathology and Laboratory Medicine, Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, Kansas, USA

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Kaiyu Kubota Department of Pathology and Laboratory Medicine, Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, Kansas, USA

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Wenfang Wang Department of Clinical Laboratory Sciences, University of Kansas Medical Center, Kansas City, Kansas, USA

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Hao Zhu Department of Clinical Laboratory Sciences, University of Kansas Medical Center, Kansas City, Kansas, USA

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Jay L Vivian Department of Pathology and Laboratory Medicine, Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, Kansas, USA

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Guoli Dai Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA

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Michael J Soares Department of Pathology and Laboratory Medicine, Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Pediatrics, University of Kansas Medical Center, Kansas City, Kansas, USA
Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, Kansas, USA
Center for Perinatal Research, Children’s Research Institute, Children’s Mercy, Kansas City, Missouri, USA

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Introduction Glucose intolerance during pregnancy, known as gestational diabetes mellitus (GDM), is one of the most common pregnancy complications and affects nearly 17% of all pregnancies globally and ~7% in the United States ( Newbern

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0518
Volume/Issue:
Volume 241: Issue 1
Free access
Jacqueline M Wallace Rowett Institute, University of Aberdeen, Aberdeen, UK

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://data.worldbank.org/indicator/sp.ado.tfrt ). Nevertheless, pregnancy during adolescence still accounts for an estimated 11% of all births worldwide with more than 95% of these occurring in developing countries ( https://www.who.int/en/news-room/fact-sheets/detail/adolescent-pregnancy ). The antecedents of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0670
Volume/Issue:
Volume 242: Issue 1
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Yiran Zhou Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

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Christine Neyt Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

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Nicola J Batchelor Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

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Rebecca L Kelley School of Biosciences, University of Melbourne, Melbourne, Australia

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Karmilla Jaafar Amsak Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

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Greg M Anderson Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand
Centre for Neuroendocrinology, University of Otago, Dunedin, New Zealand

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Dorothy E Oorschot Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand
Brain Health Research Centre, University of Otago, Dunedin, New Zealand

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Christine L Jasoni Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand
Centre for Neuroendocrinology, University of Otago, Dunedin, New Zealand

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Jane E Girling Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

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Michael W Pankhurst Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

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causes primordial follicle atresia in the long-term ( Pankhurst et al. 2018 ). In early pregnancy, transgenic AMH overexpression leads to high rates of fetal resorption in mice ( Pankhurst et al. 2018 ). Recombinant AMH administered during late

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0430
Volume/Issue:
Volume 253: Issue 2
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Bushra Taqui Lawson Health Research Institute, Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada

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Farzad Asadi Lawson Health Research Institute, Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada

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Evangelina Capobianco CONICET-Universidad de Buenos Aires, Laboratory of Reproduction and Metabolism, CEFYBO, Buenos Aires, Argentina

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Daniel Barry Hardy Departments of Obstetrics and Gynaecology and Physiology & Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada

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Alicia Jawerbaum CONICET-Universidad de Buenos Aires, Laboratory of Reproduction and Metabolism, CEFYBO, Buenos Aires, Argentina

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Edith Juliana Arany Lawson Health Research Institute, Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada

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development and variations to dietary fat composition has major implications, both short- and long-term, on offspring health ( Herrera 2002 , Berti et al. 2016 ). For example, oleic acid, a monounsaturated fatty acid (MUFA) given in pregnancy to diabetic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0047
Volume/Issue:
Volume 246: Issue 2
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Antonia Hufnagel University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Laura Dearden University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Denise S Fernandez-Twinn University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Susan E Ozanne University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Introduction Around 50% of women worldwide enter pregnancy overweight or obese ( Hill et al. 2019 ). Maternal obesity is the main risk factor for the development of gestational diabetes mellitus (GDM) in pregnancy, which affects

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-21-0332
Volume/Issue:
Volume 253: Issue 2
Open access
Jessica Milano-Foster Division of Animal Sciences, 245 Bond Life Sciences Center, 1201 Rollins Dr University of Missouri, Columbia, Missouri, USA

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Laura C Schulz Department of Obstetrics, Gynecology and Women’s Health, N610 Medical Sciences Building, Columbia, Missouri, USA

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postdoctoral fellowships at Boston University and the University of Missouri. Schulz studies the physiology of pregnancy, with a particular focus on the placenta and its role in health and disease. Current projects include studying the role of the placenta in

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JOE-23-0008
Volume/Issue:
Volume 258: Issue 1
Free access