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Marian Ludgate School of Medicine, Centre for Endocrine and Diabetes Sciences, Cardiff University, Heath Park, Cardiff CF14 4XN, UK

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In a paper entitled ‘Influence of thyroidectomy on thyroxine metabolism and turnover rate in rats’, Nagao et al . (2011) have investigated thyroid hormone kinetics in the hypothyroid state. In a number of carefully performed studies, which rely

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0159
Volume/Issue:
Volume 210: Issue 1
Free access
Diletta Piccirilli Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

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Enke Baldini Department of Surgical Sciences, ‘Sapienza’ University of Rome, Rome, Italy

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Micol Massimiani Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

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Antonella Camaioni Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

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Antonietta Salustri Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

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Roberta Bernardini Department of Biology, NSTA, II University of Rome, Tor Vergata, Italy

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Marco Centanni Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy

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Salvatore Ulisse Department of Surgical Sciences, ‘Sapienza’ University of Rome, Rome, Italy

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Costanzo Moretti Department of Systems’ Medicine University of Rome Tor Vergata, UOC of Endocrinology and Diabetes, Section of Reproductive Endocrinology Fatebenefratelli Hospital, ‘Isola Tiberina’, Rome, Italy

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Luisa Campagnolo Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

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invasion). The balance between MMPs and TIMPs strongly influences the process of invasion ( Staun-Ram & Shalev 2005 ). Among the hormones involved in the regulation of mammalian reproduction, thyroid hormone (TH) has been one of the most debated. THs are

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0436
Volume/Issue:
Volume 236: Issue 1
Free access
J Patel School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia
School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia

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K Landers School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia

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H Li School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia

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R H Mortimer School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia
School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia
School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia

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K Richard School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia
School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia

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development was made very much later ( Cranefield 1962 , Morreale de Escobar et al . 2004 ). Thyroid hormones (thyroxine (T 4 ) and triiodothyronine (T 3 )) are essential for the development and maintenance of normal physiological processes, especially

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0444
Volume/Issue:
Volume 209: Issue 1
Free access
Aline Cordeiro Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Avenida Carlos Chagas Filho, 373, Bloco G, Cidade Universitária - Ilha do Fundão, Rio de Janeiro - RJ 21941-902, Brazil

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Luana Lopes Souza Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Avenida Carlos Chagas Filho, 373, Bloco G, Cidade Universitária - Ilha do Fundão, Rio de Janeiro - RJ 21941-902, Brazil

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Marcelo Einicker-Lamas Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Avenida Carlos Chagas Filho, 373, Bloco G, Cidade Universitária - Ilha do Fundão, Rio de Janeiro - RJ 21941-902, Brazil

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Carmen Cabanelas Pazos-Moura Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Avenida Carlos Chagas Filho, 373, Bloco G, Cidade Universitária - Ilha do Fundão, Rio de Janeiro - RJ 21941-902, Brazil

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Thyroid hormone effects on lipid metabolism The thyroid hormones, triiodothyronine (T 3 ) and thyroxine (T 4 ), modulate several physiological processes in organisms and are critical in the growth, development, differentiation and maintenance of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0542
Volume/Issue:
Volume 216: Issue 3
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Márcia Santos Wagner Endocrine Division, Thyroid Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 90035-033, Porto Alegre, RS, Brasil

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Simone Magagnin Wajner Endocrine Division, Thyroid Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 90035-033, Porto Alegre, RS, Brasil

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Ana Luiza Maia Endocrine Division, Thyroid Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 90035-033, Porto Alegre, RS, Brasil

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that the adult testis of experimental animals was metabolically unresponsive to thyroid hormones ( Barker & Klitgaard 1952 ), and to the low number of thyroid hormone-binding sites found in the adult organ ( Oppenheimer et al . 1974 ). These early

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0218
Volume/Issue:
Volume 199: Issue 3
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K Boelaert Division of Medical Sciences, IBR Building, 2nd floor, The Medical School, University of Birmingham, Birmingham B15 2TT, UK

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J A Franklyn Division of Medical Sciences, IBR Building, 2nd floor, The Medical School, University of Birmingham, Birmingham B15 2TT, UK

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a neurological or a skin disorder ( Gull 1874 , Sawin 2000 ). The dramatic increase in our understanding of thyroid hormone action as well as of the clinical implications of thyroid dysfunction that has occurred during the last two centuries, will

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.1.06131
Volume/Issue:
Volume 187: Issue 1
Free access
Anne H van der Spek Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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Eric Fliers Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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Anita Boelen Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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Introduction The interplay between the endocrine and immune system is well established ( Besedovsky & del Rey 1996 , Klein 2006 , Schaefer & Klein 2011 ). Thyroid hormone (TH) metabolism and TH status have been linked to various aspects of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0462
Volume/Issue:
Volume 232: Issue 2
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Juan Bernal Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC) and Universidad Autónoma de Madrid, Madrid, Spain

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Beatriz Morte Center for Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

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Diego Diez Immunology Frontier Research Center, Osaka University, Osaka, Japan

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Introduction Thyroid hormones are crucial for brain development, acting through nuclear receptors for T3 to control gene expression ( Brent 2012 , Mendoza & Hollenberg 2017 ). The amount of T3 reaching the nucleus of target cells depends

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0189
Volume/Issue:
Volume 255: Issue 3
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Xuan Zhou Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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Yanan Zhang Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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Youwen Yuan Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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Fei Teng Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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Jiayang Lin Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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Xueru Ye Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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Yaojin Pan Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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Huijie Zhang Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China
Guangdong Provincial Key Laboratory of Shock and Microcirculation, Guangzhou, China

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Introduction Thyroid hormone (TH) performs vital functions in energy expenditure and homeostasis. Under physiological circumstances, TH is essential for sustaining basal metabolic rate (BMR), facilitating adaptive thermogenesis, and modulating

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0412
Volume/Issue:
Volume 262: Issue 2
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A J Forhead Department of Physiology, Department of Biological and Medical Sciences, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK
Department of Physiology, Department of Biological and Medical Sciences, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK

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A L Fowden Department of Physiology, Department of Biological and Medical Sciences, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK

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Introduction The thyroid hormones, thyroxine (T 4 ) and triiodothyronine (T 3 ), are detectable in the fetal circulation from early in gestation and have important developmental, metabolic, and maturational effects in the fetus in all species

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0025
Volume/Issue:
Volume 221: Issue 3
Free access