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Shan-xue Jin, David A Dickson, Jamie Maguire, and Larry A Feig

carried out using a two-way ANOVA (factors: Cre, 3DS) in the same fashion as described above. For time course studies, analyses were carried out using mixed effect models for each age/sex of mouse individually, as each time point was gathered from a

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William F Powell Jr, Kevin J Barry, Irena Tulum, Tatsuya Kobayashi, Stephen E Harris, F Richard Bringhurst, and Paola Divieti Pajevic

have generated transgenic mice in which the 10-kb promoter of Dmp1 drives a tamoxifen-inducible bacteriophage Cre-recombinase. These mice were crossed with mice in which exon 1 of the PPR gene was flanked by lox-P sites to generate animals that

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Iyad H Manaserh, Emily Maly, Marziyeh Jahromi, Lakshmikanth Chikkamenahalli, Joshua Park, and Jennifer Hill

( Ir KO GFAP mice), GFAP-Cre mice (C57Bl/J6) (Frederick National Laboratory for Cancer Research, Frederick, MD, USA) were crossed with Ir loxp mice (C57Bl/J6) in which exon 4 of the Ir gene was flanked by loxP sites ( Könner et al. 2007 ). GFAP

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Jackson Nteeba, Kaiyu Kubota, Wenfang Wang, Hao Zhu, Jay L Vivian, Guoli Dai, and Michael J Soares

conditionally delete Prlr from β cells ( Banerjee et al. 2016 ). In their model, loss of PRLR signaling in β cells resulted in GDM, reduced β cell proliferation and impaired β cell mass expansion during pregnancy ( Banerjee et al. 2016 ). The RIP- Cre has

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Soo Ok Lee, Jing Tian, Chiung-Kuei Huang, Zhifang Ma, Kuo-Pao Lai, HsiMin Hsiao, Ming Jiang, Shuyuan Yeh, and Chawnshang Chang

, although the endogenous AR level is very low. We developed a mouse model in which AR is specifically knocked out in basal epithelial cells (basal-ARKO) by mating male CK5-Cre mice with female floxAR mice ( Yeh et al . 2002 ). The Supplementary Figure 3 A

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Tao Xie, Min Chen, and Lee S Weinstein

, PGsKO had relatively increased numbers of α-cells, and a similar finding was observed in a similar mouse model that was generated using neurogenin 3 ( Ngn3 ) promoter-cre mice. Studies in the α-cell line αTC1 showed that G s α/cAMP signaling inhibits α

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Laura E Pascal, Khalid Z Masoodi, June Liu, Xiaonan Qiu, Qiong Song, Yujuan Wang, Yachen Zang, Tiejun Yang, Yao Wang, Lora H Rigatti, Uma Chandran, Leandro M Colli, Ricardo Z N Vencio, Yi Lu, Jian Zhang, and Zhou Wang

maintaining prostate homeostasis similar to EAF2. In the current study, the potential role of ELL2 in the prostate was explored in a murine knockout model. Conditional prostate epithelial cell-specific Ell2 -knockout mice were generated and examined for

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Manuel D Gahete, Juan M Jiménez-Vacas, Emilia Alors-Pérez, Vicente Herrero-Aguayo, Antonio C Fuentes-Fayos, Sergio Pedraza-Arévalo, Justo P Castaño, and Raúl M Luque

. Endocrine syndrome Model name Tumor type Model type Gene (promoter*) References MEN1 MEN1 +/− Pancreatic NET Pituitary Parathyroid Thyroid Adrenal Gonadal Heterozygous knockout Men1 Piret & Thakker (2011) PTH

Open access

Bernard Freudenthal, John Logan, Sanger Institute Mouse Pipelines, Peter I Croucher, Graham R Williams, and J H Duncan Bassett

two functions by creating either a reporter-tagged knockout or a conditional mutation if the gene-trap cassette is removed by FLP recombinase, thereby reverting the knockout mutation to wild type, although with addition of loxP sites that flank a

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Jian Ma, Xin He, Yan Cao, Kienan O’Dwyer, Katherine M Szigety, Yuan Wu, Buddha Gurung, Zijie Feng, Bryson W Katona, and Xianxin Hua

model. Materials and methods Mice and cell line Cre/loxP strategy was used to develop Prmt5 islet-specific conditional KO mouse ( Fig. 1 ). The mice with Prmt5 tm1a (EUCOMM) Wtsi (from the Wellcome Sanger Institute