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Jinyu Ma
Jinyu Ma
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China
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Yuejun Wang
Yuejun Wang
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China
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Jie Ding
Jie Ding
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China
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Shouping Zhang
Shouping Zhang
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China
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Yinuo Yang
Yinuo Yang
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China
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Cheng Sun
Cheng Sun
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China
Nantong Key Laboratory of Translational Medicine in Cardiothoracic Diseases, Institute of Translational Medicine in Cardiothoracic Diseases, Affiliated Hospital of Nantong University, Nantong, China
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Nantong Key Laboratory of Translational Medicine in Cardiothoracic Diseases, Institute of Translational Medicine in Cardiothoracic Diseases, Affiliated Hospital of Nantong University, Nantong, China
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cells are activated to express UCP1, promoting energy expenditure and heat production. This process is called white fat browning ( Carneheim et al. 1984 , Au-Yong 2009 , Chartoumpekis et al. 2011 , Nedergaard & Cannon 2014 ). Several studies have
Johanna L Barclay
Johanna L Barclay
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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Hadiya Agada
Hadiya Agada
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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Christina Jang
Christina Jang
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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Micheal Ward
Micheal Ward
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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Neil Wetzig
Neil Wetzig
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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Ken K Y Ho
Ken K Y Ho
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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Introduction Brown adipose tissue (BAT) plays an important role in thermoregulation and energy balance in rodents. Thermogenesis in BAT is achieved by uncoupling protein 1 (UCP1), which dissociates ATP synthesis from the mitochondrial
M G Gnanalingham
M G Gnanalingham
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
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A Mostyn
A Mostyn
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
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D S Gardner
D S Gardner
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
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T Stephenson
T Stephenson
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
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M E Symonds
M E Symonds
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
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; and local glucocorticoid action, as determined by the abundance of glucocorticoid receptor (GR) and isoforms of 11 β-hydroxysteroid dehydrogenase (11βHSD). The locations and postulated roles of UCP2, VDAC and cytochrome c are outlined in Fig. 1
Chunchun Wei
Chunchun Wei
Department of Pathophysiology, Naval Medical University, Shanghai, China
Department of Physiology, Naval Medical University, Shanghai, China
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Department of Physiology, Naval Medical University, Shanghai, China
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Xianhua Ma
Xianhua Ma
Department of Pathophysiology, Naval Medical University, Shanghai, China
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Kai Su
Kai Su
Department of Pathophysiology, Naval Medical University, Shanghai, China
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Shasha Qi
Shasha Qi
Department of Pathophysiology, Naval Medical University, Shanghai, China
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Yuangang Zhu
Yuangang Zhu
The State Key Laboratory of Membrane Biology, Center for Life Sciences and Institute of Molecular Medicine, Peking University, Beijing, China
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Junjian Lin
Junjian Lin
Department of Pathophysiology, Naval Medical University, Shanghai, China
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Chenxin Wang
Chenxin Wang
The State Key Laboratory of Membrane Biology, Center for Life Sciences and Institute of Molecular Medicine, Peking University, Beijing, China
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Rui Yang
Rui Yang
Department of Pathophysiology, Naval Medical University, Shanghai, China
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Xiaowei Chen
Xiaowei Chen
The State Key Laboratory of Membrane Biology, Center for Life Sciences and Institute of Molecular Medicine, Peking University, Beijing, China
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Weizhong Wang
Weizhong Wang
Department of Physiology, Naval Medical University, Shanghai, China
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Weiping J Zhang
Weiping J Zhang
Department of Pathophysiology, Naval Medical University, Shanghai, China
NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin, China
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NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin, China
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patients with T2D ( Yoneshiro et al . 2013 , Hanssen et al . 2015 ). BAT generates heat by an adaptive process called non-shivering thermogenesis (NST), which is mediated by uncoupling protein 1 (UCP1) ( Porter et al . 2016 ). Upon acute cold
Laura M Clart
Laura M Clart
Department of Nutrition and Exercise Physiology, University of Missouri System, Columbia, Missouri, USA
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Rebecca J Welly
Rebecca J Welly
Department of Nutrition and Exercise Physiology, University of Missouri System, Columbia, Missouri, USA
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Eric D Queathem
Eric D Queathem
Department of Nutrition and Exercise Physiology, University of Missouri System, Columbia, Missouri, USA
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R Scott Rector
R Scott Rector
Department of Nutrition and Exercise Physiology, University of Missouri System, Columbia, Missouri, USA
Internal Medicine-Division of Gastroenterology and Hepatology, University of Missouri System, Columbia, Missouri, USA
Research Service, Truman VA Memorial Hospital, Columbia, Missouri, USA
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Internal Medicine-Division of Gastroenterology and Hepatology, University of Missouri System, Columbia, Missouri, USA
Research Service, Truman VA Memorial Hospital, Columbia, Missouri, USA
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Jaume Padilla
Jaume Padilla
Department of Nutrition and Exercise Physiology, University of Missouri System, Columbia, Missouri, USA
Dalton Cardiovascular Research Center, University of Missouri System System, Columbia, Missouri, USA
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Dalton Cardiovascular Research Center, University of Missouri System System, Columbia, Missouri, USA
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Christopher P Baines
Christopher P Baines
Department of Biomedical Sciences, University of Missouri System, Columbia, Missouri, USA
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Jill A Kanaley
Jill A Kanaley
Department of Nutrition and Exercise Physiology, University of Missouri System, Columbia, Missouri, USA
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Dennis B Lubahn
Dennis B Lubahn
Department of Biochemistry, University of Missouri System, Columbia, Missouri, USA
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Victoria J Vieira-Potter
Victoria J Vieira-Potter
Department of Nutrition and Exercise Physiology, University of Missouri System, Columbia, Missouri, USA
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question. Pharmacological activation of ERb has been shown to increase adipocyte mitochondrial function in mice and significantly upregulate uncoupling protein 1 (UCP1), the signature protein in beige and BAT ( Ponnusamy et al. 2017 ). Interestingly, in
M A Hyatt
M A Hyatt
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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D H Keisler
D H Keisler
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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H Budge
H Budge
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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M E Symonds
M E Symonds
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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HUGO Database) and the enzymes 11β-hydroxysteroid dehydrogenase (HSD11B) types 1 and 2 as well as uncoupling protein 2 (UCP2) and peroxisome proliferator-activated receptor γ (PPARG; Whorwood et al . 2001 , Bispham et al . 2005 , Gnanalingham et
Junlan Zhou
Junlan Zhou
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Min Cheng
Min Cheng
Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA
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Chan Boriboun
Chan Boriboun
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Mariam M Ardehali
Mariam M Ardehali
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Changfei Jiang
Changfei Jiang
Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA
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Qinghua Liu
Qinghua Liu
Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA
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Shuling Han
Shuling Han
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David A Goukassian
David A Goukassian
Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA
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Yao-Liang Tang
Yao-Liang Tang
Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA
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Ting C Zhao
Ting C Zhao
Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA
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Ming Zhao
Ming Zhao
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Lu Cai
Lu Cai
Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA
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Stéphane Richard
Stéphane Richard
Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA
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Raj Kishore
Raj Kishore
Department of Medicine–Cardiology, Department of Cardiology, Department of Biochemistry, Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, GeneSys Research Institute, Department of Medicine, Department of Surgery, Kosair Children Hospital Research Institute, Lady Davis Institute for Medical Research, Center for Translational Medicine, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Tarry 14‐721, Chicago, Illinois 60611, USA
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Gangjian Qin
Gangjian Qin
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(BAT), on the other hand, is a key site of energy expenditure via heat production (thermogenesis). The brown adipocytes display multilocular lipid droplet structures and express uncoupling protein 1 ( Ucp1 ), which, when activated, short circuits the
Monisha Rajasekaran
Monisha Rajasekaran
Department of Biological Sciences, University of Ulsan, Ulsan, Korea
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Ok-Joo Sul
Ok-Joo Sul
Department of Biological Sciences, University of Ulsan, Ulsan, Korea
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Eun-Kyung Choi
Eun-Kyung Choi
Department of Biological Sciences, University of Ulsan, Ulsan, Korea
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Ji-Eun Kim
Ji-Eun Kim
Department of Biological Sciences, University of Ulsan, Ulsan, Korea
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Jae-Hee Suh
Jae-Hee Suh
Department of Pathology, Ulsan University Hospital, Ulsan, Korea
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Hye-Seon Choi
Hye-Seon Choi
Department of Biological Sciences, University of Ulsan, Ulsan, Korea
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(UCP-1) rather than producing ATP. A lean and healthy phenotype is associated with elevated BAT in animals, suggesting that modulating BAT could be used for protection against obesity. BAT is present at distinct anatomical sites, whereas brown fat cells
PJ Scarpace
PJ Scarpace
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M Matheny
M Matheny
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RL Moore
RL Moore
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MV Kumar
MV Kumar
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We recently reported that the leptin-induced increase in uncoupling protein 1 (UCP1) mRNA in brown adipose tissue (BAT) is prevented by the denervation of BAT. We also reported that retinoic acid (RA) increases UCP1 mRNA in BAT. To extend these finding to UCP2 and UCP3 in BAT, we examined UCP2 and UCP3 mRNA after unilateral denervation of BAT, as well as after leptin, beta(3)-adrenergic agonist, RA, and glucocorticoid administration to rats. UCP3 mRNA was 20% less in the denervated compared with the intact BAT, whereas UCP2 mRNA was unchanged with denervation. The beta(3)-adrenergic agonist, CGP-12177 (0.75 mg/kg), increased UPC3 mRNA by 40% in the innervated and by 85% in the denervated BAT. Leptin (0.9 mg/day for 3 days) increased both UCP2 and UCP3 mRNA by 30% in the innervated and, surprisingly, in the denervated BAT. RA (7.5 mg/kg) increased UCP1 mRNA but decreased UCP2 and UCP3 mRNA by 50%, whereas methylprednisolone (65 mg/kg, two doses 24 h apart) suppressed all three uncoupling proteins by greater than 60%. The present findings indicate that: sympathetic innervation is necessary to maintain basal levels of UCP3 mRNA; beta(3)-adrenergic agonist stimulation induces UCP3 mRNA; leptin induces UCP2 and UCP3 mRNA and this induction is not dependent on sympathetic innervation; RA increases UCP1 but decreases UCP2 and UCP3 mRNA; and methylprednisolone suppresses UCP1, UCP2, and UCP3 mRNA equally. These data suggest that there are distinct patterns of regulation between UCP1, UCP2, and UCP3, and there may be at least two modes by which leptin could modulate thermogenesis in BAT; first, by increasing sympathetic stimulation of BAT and induction of UCP1 mRNA and, secondly, by increasing UCP2 and UCP3 mRNA by a mechanism independent of sympathetic stimulation.
Patricia C Lisboa
Patricia C Lisboa
Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Avenida 28 de setembro, 87, Rio de Janeiro, RJ 20551‐031, Brazil
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Ellen P S Conceição
Ellen P S Conceição
Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Avenida 28 de setembro, 87, Rio de Janeiro, RJ 20551‐031, Brazil
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Elaine de Oliveira
Elaine de Oliveira
Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Avenida 28 de setembro, 87, Rio de Janeiro, RJ 20551‐031, Brazil
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Egberto G Moura
Egberto G Moura
Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Avenida 28 de setembro, 87, Rio de Janeiro, RJ 20551‐031, Brazil
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the pituitary gland and the in vitro TSH secretion both under basal conditions and after TRH stimulation. Additionally, we studied the uncoupling protein 1 (UCP1) in BAT and the mitochondrial α-glycerol-3-phosphate dehydrogenase (mGPD) activity in
