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Sun-O Ka Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea

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Mi-Young Song Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea

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Eun Ju Bae Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea

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Byung-Hyun Park Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea

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release from stimulated macrophages ( Yoshizaki et al . 2010 , Zhang et al . 2010 ). Myeloid-cell-specific deletion of Sirt1 increases macrophage infiltration into the liver and adipose tissues, as well as production of proinflammatory cytokines, and

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Kayo Mori Laboratory of Molecular and Cellular Biochemistry, Division of Oral Biological Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Department of Cell Biology, Aging Science, and Pharmacology, Division of Oral Biological Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka, Japan
Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Kyushu University, Higashi-ku, Fukuoka, Japan

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Akiko Mizokami Oral Health/Brain Health/Total Health Research Center, Kyushu University, Higashi-ku, Fukuoka, Japan

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Tomomi Sano Department of Cell Biology, Aging Science, and Pharmacology, Division of Oral Biological Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka, Japan

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Satoru Mukai Department of Health and Nutrition Care, Faculty of Allied Health Sciences, University of East Asia, Shimonoseki, Japan

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Fumitaka Hiura Laboratory of Molecular and Cellular Biochemistry, Division of Oral Biological Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan

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Yasunori Ayukawa Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Kyushu University, Higashi-ku, Fukuoka, Japan

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Kiyoshi Koyano Division of Advanced Dental Devices and Therapeutics, Faculty of Dental Science, Kyushu University, Fukuoka, Japan

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Takashi Kanematsu Department of Cell Biology, Aging Science, and Pharmacology, Division of Oral Biological Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka, Japan

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Eijiro Jimi Laboratory of Molecular and Cellular Biochemistry, Division of Oral Biological Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Oral Health/Brain Health/Total Health Research Center, Kyushu University, Higashi-ku, Fukuoka, Japan

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significance was set at P < 0.05. Results Prolonged RANKL stimulation induces Tnfa expression via the non-canonical NF-κB pathway in BMCs Adipose tissue macrophages, some recruited from bone marrow-derived macrophages, contribute to

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Dario A Gutierrez Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Room 702 Light Hall, Nashville, Tennessee 37232-0615, USA

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Alyssa H Hasty Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Room 702 Light Hall, Nashville, Tennessee 37232-0615, USA

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Introduction Accumulation of inflammatory macrophages in adipose tissue (AT) during obesity has been shown to correlate with AT inflammation and subsequent insulin resistance (IR; Weisberg et al . 2003 , Xu et al . 2003 ). In addition, the

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Tsutomu Wada Department of Clinical Pharmacology, University of Toyama, Toyama, Japan

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Akari Ishikawa Department of Clinical Pharmacology, University of Toyama, Toyama, Japan

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Eri Watanabe Department of Clinical Pharmacology, University of Toyama, Toyama, Japan

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Yuto Nakamura Department of Clinical Pharmacology, University of Toyama, Toyama, Japan

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Yusuke Aruga Department of Clinical Pharmacology, University of Toyama, Toyama, Japan

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Hayate Hasegawa Department of Clinical Pharmacology, University of Toyama, Toyama, Japan

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Yasuhiro Onogi Department of Clinical Pharmacology, University of Toyama, Toyama, Japan

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Hiroe Honda Department of Immunobiology and Pharmacological Genetics, University of Toyama, Toyama, Japan
Toyama Prefectural Institute for Pharmaceutical Research, Toyama, Japan

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Yoshinori Nagai Department of Immunobiology and Pharmacological Genetics, University of Toyama, Toyama, Japan
JST, PRESTO, Saitama, Japan

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Kiyoshi Takatsu Department of Immunobiology and Pharmacological Genetics, University of Toyama, Toyama, Japan
Toyama Prefectural Institute for Pharmaceutical Research, Toyama, Japan

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Yoko Ishii Department of Pathology, University of Toyama, Toyama, Japan

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Masakiyo Sasahara Department of Pathology, University of Toyama, Toyama, Japan

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Daisuke Koya Department of Internal Medicine, Kanazawa Medical University, Ishikawa, Japan

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Hiroshi Tsuneki Department of Clinical Pharmacology, University of Toyama, Toyama, Japan

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Toshiyasu Sasaoka Department of Clinical Pharmacology, University of Toyama, Toyama, Japan

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of polarity, namely inflammatory M1 and anti-inflammatory M2 ( Fujisaka et al. 2009 ). Most resident macrophages in the lean visceral adipose tissue are classified as M2, whereas M1-macrophages increase when adipose tissue expands in obesity and

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Eun-Kyung Choi
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Woon-Ki Kim
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Ok-Joo Sul
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Yun-Kyung Park
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Eun-Sook Kim Department of Biological Sciences, Department of Endocrinology, Department of Pathology, Department of Food Science and Nutrition, University of Ulsan, Ulsan 680-749, Korea

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Jae-Hee Suh Department of Biological Sciences, Department of Endocrinology, Department of Pathology, Department of Food Science and Nutrition, University of Ulsan, Ulsan 680-749, Korea

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Rina Yu Department of Biological Sciences, Department of Endocrinology, Department of Pathology, Department of Food Science and Nutrition, University of Ulsan, Ulsan 680-749, Korea

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Hye-Seon Choi
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tibiae were removed aseptically and dissected free of adherent soft tissue. The bone ends were cut and the marrow cavity was flushed out with α-MEM (minimum essential media) from one end of the bone, using a sterile 21-gauge needle. The bone marrow was

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Richard C Lindsey Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, California, USA
Center for Health Disparities and Molecular Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA
Division of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA

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Catrina Godwin Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, California, USA

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Subburaman Mohan Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, California, USA
Center for Health Disparities and Molecular Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA
Division of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA
Department of Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA
Department of Orthopedics, School of Medicine, Loma Linda University, Loma Linda, California, USA

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resolution of 10.5 μm with a 55 kVp X-ray for measurement of trabecular bone microstructure. Trabecular bone parameters were analyzed as described previously ( Cheng et al. 2014 ). Marrow adipose tissue was visualized and quantified as described ( Scheller

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Jessica L Pierce Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Ke-Hong Ding Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Jianrui Xu Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Anuj K Sharma Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Kanglun Yu Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Natalia del Mazo Arbona Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Zuleika Rodríguez-Santos Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Paul J Bernard Pediatric Endocrine Specialists of Georgia, Duluth, Georgia, USA

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Wendy B Bollag Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
Department of Physiology, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA
Charlie Norwood VA Medical Center, Augusta, Georgia, USA

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Maribeth H Johnson Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Mark W Hamrick Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA

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Dana L Begun Department of Orthopaedic Surgery, Mayo Clinic, Rochester, Minnesota, USA

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Xing-Ming Shi Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA

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Carlos M Isales Department of Neuroscience and Regenerative Medicine, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Augusta University, Augusta, Georgia, USA

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Meghan E McGee-Lawrence Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA

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-adrenergic signaling during CR shows differing roles in terms of facilitating bone loss and marrow fat accumulation ( Baek & Bloomfield 2012 , Baek et al. 2014 b ). It was also recently reported that marrow adipose tissue has a blunted response to adrenergic

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Dimitrios Agas School of Bioscience and Veterinary Medicine, University of Camerino, Camerino, Italy

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Guilherme Gusmão Silva Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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Fulvio Laus School of Bioscience and Veterinary Medicine, University of Camerino, Camerino, Italy

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Andrea Marchegiani School of Bioscience and Veterinary Medicine, University of Camerino, Camerino, Italy

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Melania Capitani School of Bioscience and Veterinary Medicine, University of Camerino, Camerino, Italy

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Cecilia Vullo School of Bioscience and Veterinary Medicine, University of Camerino, Camerino, Italy

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Giuseppe Catone School of Bioscience and Veterinary Medicine, University of Camerino, Camerino, Italy

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Giovanna Lacava School of Bioscience and Veterinary Medicine, University of Camerino, Camerino, Italy

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Antonio Concetti School of Bioscience and Veterinary Medicine, University of Camerino, Camerino, Italy

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Luigi Marchetti School of Bioscience and Veterinary Medicine, University of Camerino, Camerino, Italy

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Maria Giovanna Sabbieti School of Bioscience and Veterinary Medicine, University of Camerino, Camerino, Italy

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) increase of adipose tissue ( Burkhardt et al. 1987 ). Discussion In our research, we addressed to the impact of INF-γ gene delivery on bone and bone marrow in osteopenic and healthy mice. The intramuscular route for injection of the INF-γ DNA

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Bronwen A J Evans School of Biosciences, Department of Child Health, Division of Molecular Neuroendocrinology, Department of Anatomy, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK

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Melanie J Bull
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Rebecca C Kench
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Rebecca E Fox
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Liam D Morgan School of Biosciences, Department of Child Health, Division of Molecular Neuroendocrinology, Department of Anatomy, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK

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Amy E Stevenson
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Evelien F Gevers School of Biosciences, Department of Child Health, Division of Molecular Neuroendocrinology, Department of Anatomy, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK

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Mark J Perry School of Biosciences, Department of Child Health, Division of Molecular Neuroendocrinology, Department of Anatomy, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK

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Timothy Wells
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been demonstrated that central leptin treatment not only inhibits pre-adipocyte differentiation ( Venken et al . 2007 ), but also induces adipocyte apoptosis in both extramedullary white adipose tissue and bone marrow ( Qian et al . 1998 , Hamrick

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Nicholaos I Papachristou Department of Anatomy-Histology-Embryology, Unit of Bone and Soft Tissue Studies, University of Patras Medical School, Patras, Greece

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Harry C Blair Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Pittsburgh VA Medical Center, Pittsburgh, Pennsylvania, USA

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Kyriakos E Kypreos Department of Pharmacology, University of Patras Medical School, Patras, Greece

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Dionysios J Papachristou Department of Anatomy-Histology-Embryology, Unit of Bone and Soft Tissue Studies, University of Patras Medical School, Patras, Greece
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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on bone cell functions, and thus, on bone mass, that possibly overcomes the impact of bone-acting circulating hormones. Indeed, conditions that are characterized by increased visceral adiposity are associated with increased bone marrow fat and reduced

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