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Introduction Diabetes mellitus is a common disorder in dogs and cats, with a reported hospital prevalence rate of ∼0.4–1.2%. Classic clinical signs of diabetes include polyuria, polydipsia, polyphagia, and weight loss. Clinical signs do not develop
Folkhälsan Research Center, University of Helsinki, Helsinki, Finland
Department of Obstetrics and Gynecology, National University of Singapore, Yong Loo Lin School of Medicine, Singapore, Singapore
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Type 2 diabetes Type 2 diabetes (T2D) is a major, rapidly increasing global public health challenge. The number of adults with diabetes is estimated to have increased from 108 to 422 million between 1980 and 2014 making it one of the fastest
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diabetes. Structure and function of the p53 tumor-suppressor protein p53 protein is made of 393 amino acids and uses a zinc-coordinated DNA-binding domain to bind in a sequence-specific manner to DNA consensus elements that contain two copies of the
German Center for Diabetes Research (DZD), Neuherberg, Germany
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German Center for Diabetes Research (DZD), Neuherberg, Germany
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German Center for Diabetes Research (DZD), Neuherberg, Germany
Division of Metabolic Diseases, Technische Universität, Munich, Germany
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German Center for Diabetes Research (DZD), Neuherberg, Germany
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obesity are associated with a number of comorbidities, most importantly type 2 diabetes (T2DM), cardiovascular disease, hypertension, dyslipidemia and several kinds of cancer, predominantly gastrointestinal (GI). In 2015, around 4 million deaths were
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understanding of the physiology of glucagon, its potential role in the causation of diabetes, and its synergistic effects with other gut hormones in regulating metabolism. In this review article, we aim to summarize the known effects of glucagon and its
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Introduction Metformin is a biguanide drug that is widely prescribed as an oral antihyperglycaemic agent internationally and is recommended as the initial drug of choice for type 2 diabetes (T2D) according to recent joint European
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Introduction The in utero environment plays an important role in the development of the fetus and the neonate ( Harris et al. 2017 , Marciniak et al. 2017 ). Pre-gestational diabetes affects organogenesis and increases the risk of
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, inflammatory bowel disease, peritonitis, multiple sclerosis, pulmonary fibrosis, and type 1 and type 2 diabetes (T1D, T2D) ( Patterson et al. 2014 ). Several of these agents have already been approved for use in several non-malignant conditions including
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Department of Applied Physiology and Kinesiology, Department of Kinesiology and Applied Physiology, Department of Kinesiology, Department of Nutrition, University of Florida, Gainesville, Florida 32611, USA
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Department of Applied Physiology and Kinesiology, Department of Kinesiology and Applied Physiology, Department of Kinesiology, Department of Nutrition, University of Florida, Gainesville, Florida 32611, USA
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Introduction The increase in fracture risk observed among patients with type 2 diabetes mellitus (T2DM) has been suggested to be associated with corollaries of the disease, such as peripheral neuropathy, decreased physical fitness, vision loss, and
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Department of Physiology, Institute of Neuroscience and Physiology, Metabolic Research Unit, University of Gothenburg, Göteborg, Sweden
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CNC - Center for Neuroscience and Cell Biology, CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
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hyperglycaemia ( Göke 2008 ). This secretory pattern becomes defective in diabetes and leads to glycaemic volatility: failure to secrete glucagon at low glucose contributes to the occurrence of hypoglycaemia ( Cryer & Gerich 1985 ), while hyperglucagonemia at
