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Douglas A Gibson
Douglas A Gibson
Centre for Inflammation Research, The University of Edinburgh, Edinburgh Bioquarter, Edinburgh, UK
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Ioannis Simitsidellis
Ioannis Simitsidellis
Centre for Inflammation Research, The University of Edinburgh, Edinburgh Bioquarter, Edinburgh, UK
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Frances Collins
Frances Collins
Centre for Inflammation Research, The University of Edinburgh, Edinburgh Bioquarter, Edinburgh, UK
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Philippa T K Saunders
Philippa T K Saunders
Centre for Inflammation Research, The University of Edinburgh, Edinburgh Bioquarter, Edinburgh, UK
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Introduction In women, the endometrium is divided into an inner/luminal functional layer (‘functionalis’) and a basal layer (‘basalis’). On its inner (luminal) aspect, columnar epithelial cells form a boundary between the fluid-filled uterine
Hwa-Yong Lee
Hwa-Yong Lee
Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Tomas J Acosta
Tomas J Acosta
Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Michiyo Tanikawa
Michiyo Tanikawa
Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Ryosuke Sakumoto
Ryosuke Sakumoto
Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Junichi Komiyama
Junichi Komiyama
Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Yukari Tasaki
Yukari Tasaki
Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Mariusz Piskula
Mariusz Piskula
Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Dariusz J Skarzynski
Dariusz J Skarzynski
Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Masafumi Tetsuka
Masafumi Tetsuka
Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Kiyoshi Okuda
Kiyoshi Okuda
Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan
Departments of Food Technology and
Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn 10-747, Poland
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan
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a target organ for GCs in some species. However, the roles of GCs in the bovine endometrium remain unknown. The endometrium is a complex tissue and mainly consists of epithelial and stromal cells ( Fortier et al. 1988 ). Although both types
M S Fernandes
M S Fernandes
Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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V Pierron
V Pierron
Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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D Michalovich
D Michalovich
Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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S Astle
S Astle
Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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S Thornton
S Thornton
Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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H Peltoketo
H Peltoketo
Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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E W-F Lam
E W-F Lam
Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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B Gellersen
B Gellersen
Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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I Huhtaniemi
I Huhtaniemi
Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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J Allen
J Allen
Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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J J Brosens
J J Brosens
Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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the endometrium that initially define a limited period of uterine receptivity (implantation window) and subsequently control differentiation of the stromal compartment (decidualization) ( Brosens et al. 1999 , Gellersen & Brosens 2003 ). This
Ioannis Simitsidellis
Ioannis Simitsidellis
Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Arantza Esnal-Zuffiaure
Arantza Esnal-Zuffiaure
Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Olympia Kelepouri
Olympia Kelepouri
Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Elisabeth O’Flaherty
Elisabeth O’Flaherty
Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Douglas A Gibson
Douglas A Gibson
Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Philippa T K Saunders
Philippa T K Saunders
Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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epithelial cells surrounding the lumen and glands of the endometrium, as well as the smooth muscle cells of the myometrium ( Simitsidellis et al. 2018 ). Studies in women and rodents have demonstrated that secretions from endometrial glands play a
Junie Hurette Chansi Kengni
Junie Hurette Chansi Kengni
Groupe de Recherche en Biopathologies Cellulaires et Moléculaires, Département de Chimie-Biologie, Université du Québec à Trois-Rivières, CP 500, Trois-Rivières, Québec, G9A 5H7 Canada
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Isabelle St-Louis
Isabelle St-Louis
Groupe de Recherche en Biopathologies Cellulaires et Moléculaires, Département de Chimie-Biologie, Université du Québec à Trois-Rivières, CP 500, Trois-Rivières, Québec, G9A 5H7 Canada
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Sophie Parent
Sophie Parent
Groupe de Recherche en Biopathologies Cellulaires et Moléculaires, Département de Chimie-Biologie, Université du Québec à Trois-Rivières, CP 500, Trois-Rivières, Québec, G9A 5H7 Canada
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Valérie Leblanc
Valérie Leblanc
Groupe de Recherche en Biopathologies Cellulaires et Moléculaires, Département de Chimie-Biologie, Université du Québec à Trois-Rivières, CP 500, Trois-Rivières, Québec, G9A 5H7 Canada
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Carl Shooner
Carl Shooner
Groupe de Recherche en Biopathologies Cellulaires et Moléculaires, Département de Chimie-Biologie, Université du Québec à Trois-Rivières, CP 500, Trois-Rivières, Québec, G9A 5H7 Canada
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Eric Asselin
Eric Asselin
Groupe de Recherche en Biopathologies Cellulaires et Moléculaires, Département de Chimie-Biologie, Université du Québec à Trois-Rivières, CP 500, Trois-Rivières, Québec, G9A 5H7 Canada
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). Decidualization can be initiated only when the endometrium is receptive, and this only occurs during a short period in pregnancy. Several decades of investigations have showed that PGs are needed to trigger the events of blastocyst implantation. Implantation
K. YAMASHITA
K. YAMASHITA
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Lutwak-Mann (1955) and Pincus, Miyake, Merrill & Longo (1957) have shown that the carbonic anhydrase activity of the uterine endometrium in rabbits primed with oestrogen is mainly under progestin control. Since the activity increased roughly proportionally to that of proliferative development, determinations of endometrial carbonic anhydrase have been utilized as a quantitative test for progestational activity. In a previous paper (Yamashita & Kurouji, 1961 a), we suggested that certain androgens prevent the activating effect of progesterone on the endometrial carbonic anhydrase. However, Lutwak-Mann (1955) has demonstrated that methyltestosterone itself produces marked increases in the content of uterine carbonic anhydrase. The present observation was made to ascertain whether androgenic steroids affect the activity of endometrial carbonic anhydrase. The following androgens were tested: methyltestosterone, androstenedione, androstanolone, stigmasterol and β-sitosterol.
Immature albino rabbits, weighing approximately 1·5 kg., were used. Clauberg's (1930) method was modified in that the animals were primed with 5 μg.
S. ZUCKERMAN
S. ZUCKERMAN
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Shahenda M El-Naggar
Shahenda M El-Naggar
Department of Biochemistry and Molecular Biology,
Department of Pathology and
Department of Medicine,
Research Resource Center, University of Louisville, Louisville, Kentucky 40202, USA,
James Graham Cancer Center, University of Louisville, 580 South Preston St Baxter II, 324, Louisville, Kentucky 40202, USA
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Department of Pathology and
Department of Medicine,
Research Resource Center, University of Louisville, Louisville, Kentucky 40202, USA,
James Graham Cancer Center, University of Louisville, 580 South Preston St Baxter II, 324, Louisville, Kentucky 40202, USA
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Mohammad T Malik
Mohammad T Malik
Department of Biochemistry and Molecular Biology,
Department of Pathology and
Department of Medicine,
Research Resource Center, University of Louisville, Louisville, Kentucky 40202, USA,
James Graham Cancer Center, University of Louisville, 580 South Preston St Baxter II, 324, Louisville, Kentucky 40202, USA
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Department of Pathology and
Department of Medicine,
Research Resource Center, University of Louisville, Louisville, Kentucky 40202, USA,
James Graham Cancer Center, University of Louisville, 580 South Preston St Baxter II, 324, Louisville, Kentucky 40202, USA
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Alvin Martin
Alvin Martin
Department of Biochemistry and Molecular Biology,
Department of Pathology and
Department of Medicine,
Research Resource Center, University of Louisville, Louisville, Kentucky 40202, USA,
James Graham Cancer Center, University of Louisville, 580 South Preston St Baxter II, 324, Louisville, Kentucky 40202, USA
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Department of Pathology and
Department of Medicine,
Research Resource Center, University of Louisville, Louisville, Kentucky 40202, USA,
James Graham Cancer Center, University of Louisville, 580 South Preston St Baxter II, 324, Louisville, Kentucky 40202, USA
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Joseph P Moore
Joseph P Moore
Department of Biochemistry and Molecular Biology,
Department of Pathology and
Department of Medicine,
Research Resource Center, University of Louisville, Louisville, Kentucky 40202, USA,
James Graham Cancer Center, University of Louisville, 580 South Preston St Baxter II, 324, Louisville, Kentucky 40202, USA
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Department of Pathology and
Department of Medicine,
Research Resource Center, University of Louisville, Louisville, Kentucky 40202, USA,
James Graham Cancer Center, University of Louisville, 580 South Preston St Baxter II, 324, Louisville, Kentucky 40202, USA
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Mary Proctor
Mary Proctor
Department of Biochemistry and Molecular Biology,
Department of Pathology and
Department of Medicine,
Research Resource Center, University of Louisville, Louisville, Kentucky 40202, USA,
James Graham Cancer Center, University of Louisville, 580 South Preston St Baxter II, 324, Louisville, Kentucky 40202, USA
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Department of Pathology and
Department of Medicine,
Research Resource Center, University of Louisville, Louisville, Kentucky 40202, USA,
James Graham Cancer Center, University of Louisville, 580 South Preston St Baxter II, 324, Louisville, Kentucky 40202, USA
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Tariq Hamid
Tariq Hamid
Department of Biochemistry and Molecular Biology,
Department of Pathology and
Department of Medicine,
Research Resource Center, University of Louisville, Louisville, Kentucky 40202, USA,
James Graham Cancer Center, University of Louisville, 580 South Preston St Baxter II, 324, Louisville, Kentucky 40202, USA
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Department of Pathology and
Department of Medicine,
Research Resource Center, University of Louisville, Louisville, Kentucky 40202, USA,
James Graham Cancer Center, University of Louisville, 580 South Preston St Baxter II, 324, Louisville, Kentucky 40202, USA
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Sham S Kakar
Sham S Kakar
Department of Biochemistry and Molecular Biology,
Department of Pathology and
Department of Medicine,
Research Resource Center, University of Louisville, Louisville, Kentucky 40202, USA,
James Graham Cancer Center, University of Louisville, 580 South Preston St Baxter II, 324, Louisville, Kentucky 40202, USA
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Department of Pathology and
Department of Medicine,
Research Resource Center, University of Louisville, Louisville, Kentucky 40202, USA,
James Graham Cancer Center, University of Louisville, 580 South Preston St Baxter II, 324, Louisville, Kentucky 40202, USA
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associated with sustained levels of estrogen on the uterus ( Tang et al. 1984 ). These glands were cystically dilated and were filled with fluid (Fig. 8 , compare a and b with e and f). In some cases, these glands occupied the entire endometrium and
B. S. SETTY
B. S. SETTY
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MAN MOHAN SINGH
MAN MOHAN SINGH
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S. R. CHOWDHURY
S. R. CHOWDHURY
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AMIYA B. KAR
AMIYA B. KAR
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SUMMARY
Sodium and potassium levels were determined in the rat endometrium and uterine washings during normal and 'delayed' implantation. Both endometrium and uterine washings of normal rats differed from those of 'delayed' animals in their electrolyte concentrations. A dose of oestradiol dipropionate (1 μg/rat) capable of inducing implantation in 'delayed' rats (ovariectomized and maintained on progesterone) did not evoke any significant changes in electrolyte concentration of either the endometrium or uterine washings. These findings are discussed in the light of a hypothesis regarding delayed implantation in rats.
S. C. Riley
S. C. Riley
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N. L. Poyser
N. L. Poyser
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ABSTRACT
The output of prostaglandin (PG) F2α from guinea-pig endometrium obtained on day 15 of the oestrous cycle and maintained in tissue culture was significantly (P<0·05) reduced by the use of Ca2+-depleted medium, EGTA (a Ca2+ chelator), 8-(N,N-diethyl-amino)octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8; an intracellular Ca2+ antagonist), trifluoperazine (TFP) and N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7; both calmodulin antagonists). Nifedipine inhibited PGF2α output at a concentration (100 μmol/l) much greater than that usually required to block Ca2+ channels. Verapamil had a small but significant (P < 0·05) inhibitory effect on PGF2α output at 10–100 μmol/l. The outputs of PGE2 and, to a lesser extent, 6-keto-PGF1α (the hydrated product of PGI2) were also reduced by using Ca2+-depleted medium. EGTA reduced the outputs of PGE2 and 6-keto-PGF1α on day 1 of culture, but stimulated 6-keto-PGF1α output on day 3 of culture. The outputs of PGE2 and 6-keto-PGF1α were increased by TMB-8 (100 μmol/l) on day 3 of culture and by TFP and, to a smaller extent, by W-7 on all 3 days of culture. Nifedipine (100 μmol/l by not 1 or 10 μmol/l) reduced the outputs of PGE2 and 6-keto-PGF1α on all 3 days of culture, whereas verapamil (100 μmol/l but not 1 or 10 μmol/l) increased the outputs of these two prostaglandins on days 2 and 3 of culture. Phorbol 12-myristate 13-acetate (an activator of protein kinase C) had no effect on the outputs of PGF2α, PGE2 and 6-keto-PGF1α from cultured guineapig endometrium obtained on days 7 and 15 of the oestrous cycle. It is concluded that extracellular Ca2+ is necessary for the high output of PGF2α from the guinea-pig uterus after day 11 of the oestrous cycle, and that the action of Ca2+ is not potentiated by the activation of protein kinase C.
J. Endocr. (1987) 113, 463–471
