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Hannah M Eggink Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

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Lauren L Tambyrajah Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Rosa van den Berg Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Isabel M Mol Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Jose K van den Heuvel Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Martijn Koehorst Department of Pediatrics and Laboratory Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

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Albert K Groen Department of Pediatrics and Laboratory Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
Department of Vascular Medicine, Amsterdam Diabetes Centre, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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Anita Boelen Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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Andries Kalsbeek Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

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Johannes A Romijn Department of Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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Patrick C N Rensen Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Sander Kooijman Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Maarten R Soeters Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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-described effects of BAs in lipid and carbohydrate metabolism, we hypothesized that central effects of BA contribute to the regulation of energy metabolism. Therefore, the aim of the present study was to determine the effects of central bile acid signaling on

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Rengasamy Palanivel Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3

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Vivian Vu Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3

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Min Park Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3

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Xiangping Fang Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3

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Gary Sweeney Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3

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Michelle M Chen
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Clarence Hale
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Shanaka Stanislaus
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Jing Xu
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Murielle M Véniant Department of Cardiometabolic Disorders, Amgen Inc., Thousand Oaks, California, USA

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selectivity and tissue expression pattern give rise to the functional specificity of FGF19 and FGF21 (Yang et al. 2012) . Based on these findings, many investigators have concluded that FGF19 is primarily involved in the regulation of bile acid metabolism

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Giselle Adriana Abruzzese Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Maria Florencia Heber Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Silvana Rocio Ferreira Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Leandro Martin Velez Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Roxana Reynoso Laboratorio de Endocrinología, Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Omar Pedro Pignataro Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Alicia Beatriz Motta Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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kit (Wiener Lab, Argentina), as described previously ( Chow et al . 2011 ). Hepatic lipid metabolism The mRNA expression of acetyl-CoA carboxylase (ACC) 1 and 2 ( Acaca and Acacb , respectively), fatty acid synthase ( Fas ), stearoyl

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M Kurtz Laboratory of Reproduction and Metabolism, UMYMFOR (CONICET‐UBA), CEFyBO‐CONICET, School of Medicine and

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E Capobianco Laboratory of Reproduction and Metabolism, UMYMFOR (CONICET‐UBA), CEFyBO‐CONICET, School of Medicine and

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V Careaga Laboratory of Reproduction and Metabolism, UMYMFOR (CONICET‐UBA), CEFyBO‐CONICET, School of Medicine and

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N Martinez Laboratory of Reproduction and Metabolism, UMYMFOR (CONICET‐UBA), CEFyBO‐CONICET, School of Medicine and

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M B Mazzucco Laboratory of Reproduction and Metabolism, UMYMFOR (CONICET‐UBA), CEFyBO‐CONICET, School of Medicine and

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M Maier Laboratory of Reproduction and Metabolism, UMYMFOR (CONICET‐UBA), CEFyBO‐CONICET, School of Medicine and

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A Jawerbaum Laboratory of Reproduction and Metabolism, UMYMFOR (CONICET‐UBA), CEFyBO‐CONICET, School of Medicine and

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development and maturation . Trends in Endocrinology and Metabolism 21 729 – 738 . ( doi:10.1016/j.tem.2010.09.001 ) Sharma S Chhibber S Mohan H 2013 Dietary supplementation with ω-3 polyunsaturated fatty acids ameliorates acute pneumonia

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Miao Hou Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Chenlin Ji Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Jing Wang Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Yanhua Liu Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Bin Sun Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Mei Guo Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Jonas Burén Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Xiaonan Li Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China
Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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). Taken together, these observations strongly suggest the existence of an association between local GC metabolism and nutritional status or fatty acid composition. In this study, we investigated the effects of three diets with different fatty acid

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Liisa Ailanen Institute of Biomedicine and Turku Center for Disease Modelling; Drug Research Doctoral Program, University of Turku, Turku, Finland

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Suvi T Ruohonen Institute of Biomedicine and Turku Center for Disease Modelling, University of Turku, Turku, Finland

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Laura H Vähätalo Institute of Biomedicine and Turku Center for Disease Modelling, University of Turku, Turku, Finland

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Katja Tuomainen Institute of Biomedicine and Turku Center for Disease Modelling, University of Turku, Turku, Finland

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Kim Eerola Institute of Biomedicine and Turku Center for Disease Modelling, University of Turku, Turku, Finland

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Henriikka Salomäki-Myftari Institute of Biomedicine and Turku Center for Disease Modelling; Drug Research Doctoral Program, University of Turku, Turku, Finland

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Matias Röyttä Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland

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Asta Laiho Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

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Markku Ahotupa Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

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Helena Gylling Department of Internal Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

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Eriika Savontaus Institute of Biomedicine and Turku Center for Disease Modelling, University of Turku; Turku University Hospital, Unit of Clinical Pharmacology, Turku, Finland

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.098 61.06 Downregulated pathways  Fatty acid metabolism 4 <0.001 0.00  PPAR signaling pathway 4 <0.001 0.00  Retinol metabolism 2 0.047 30.06  Arachidonic acid metabolism 2 0.057 35

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Aldo Grefhorst Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Johanna C van den Beukel Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Wieneke Dijk Division of Human Nutrition, Nutrition, Metabolism, and Genomics Group, Wageningen University, Wageningen, The Netherlands

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Jacobie Steenbergen Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Gardi J Voortman Section of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Selmar Leeuwenburgh Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Theo J Visser Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Sander Kersten Division of Human Nutrition, Nutrition, Metabolism, and Genomics Group, Wageningen University, Wageningen, The Netherlands

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Edith C H Friesema Section of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Axel P N Themmen Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Jenny A Visser Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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. Journal of Biological Chemistry 277 34182 – 34190 . ( https://doi.org/10.1074/jbc.M204887200 ) 10.1074/jbc.M204887200 Harris WS Hustvedt BE Hagen E Green MH Lu G Drevon CA 1997 N-3 fatty acids and chylomicron metabolism in the rat

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Sung-Soo Park Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju, South Korea

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Yeon-Joo Lee Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju, South Korea

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Sooyeon Song Division of Animal Science, College of Agriculture & Life Science, Chonnam National University, Gwangju, South Korea

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Boyong Kim Gwangju Center, Korea Basic Science Institute, Gwangju, South Korea

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Hyuno Kang Gwangju Center, Korea Basic Science Institute, Gwangju, South Korea

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Sejong Oh Division of Animal Science, College of Agriculture & Life Science, Chonnam National University, Gwangju, South Korea

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Eungseok Kim Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju, South Korea

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mediate the phenotype of HFD-LNS1 mice, we next analyzed the expression profiles of genes involved in lipid metabolism by RT-qPCR. HFD feeding resulted in increased expression of the genes involved in lipogenesis, including Srebp-1c , fatty acid synthase

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Melanie Tran Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Golam Mostofa Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Michael Picard Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Jianguo Wu Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Li Wang Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA

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Dong-Ju Shin Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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.2174/1573399810666140508121012 ) Wang T Fahrmann JF Lee H Li YJ Tripathi SC Yue C Zhang C Lifshitz V Song J Yuan Y 2018 JAK/STAT3-regulated fatty acid β-oxidation is critical for breast cancer stem cell self-renewal and chemoresistance . Cell Metabolism 27 136

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