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Rosemari Otton
Rosemari Otton
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Danielly Oliveira da Silva
Danielly Oliveira da Silva
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Thais Regina Campoio
Thais Regina Campoio
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Leonardo R Silveira
Leonardo R Silveira
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Maria Oliveira de Souza
Maria Oliveira de Souza
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Elaine Hatanaka
Elaine Hatanaka
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Rui Curi
Rui Curi
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Keld Fosgerau
Keld Fosgerau
In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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Christian Fledelius
Christian Fledelius
In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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Kent E Pedersen
Kent E Pedersen
In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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Jesper B Kristensen
Jesper B Kristensen
In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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Jens R Daugaard
Jens R Daugaard
In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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Miguel A Iglesias
Miguel A Iglesias
In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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Edward W Kraegen
Edward W Kraegen
In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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Stuart M Furler
Stuart M Furler
In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia
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utilization as fuel ( Kelley & Goodpaster 2001 ). Consequently, there is considerable interest in defining the processes that control the intracellular partitioning of free fatty acid (FFA) between oxidation and storage pathways. A key control point is
A Margot Umpleby
A Margot Umpleby
Diabetes and Metabolic Medicine, Faculty of Health and Metabolic Sciences, University of Surrey, Leggett Building, Daphne Jackson Road, Manor Park, Guildford GU2 7WG, UK
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measuring expired 13 CO 2 generated from the oxidation of a 13 C-labelled molecule and for measuring the enrichment of labelled plasma water ( 2 H 2 O) which is used in the measurement of fatty acid synthesis. For more details on measurement techniques
Rengasamy Palanivel
Rengasamy Palanivel
Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3
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Vivian Vu
Vivian Vu
Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3
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Min Park
Min Park
Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3
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Xiangping Fang
Xiangping Fang
Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3
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Gary Sweeney
Gary Sweeney
Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3
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accumulation ( McGavock et al . 2006 ), as this can lead to lipotoxic effects such as apoptosis or insulin resistance ( Borradaile & Schaffer 2005 ). A decrease in glucose transport, glycolysis, and glucose oxidation, together with an increase in fatty acid
Sihan Lv
Sihan Lv
Department of Endocrinology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
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Xinchen Qiu
Xinchen Qiu
Department of Endocrinology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Jian Li
Jian Li
Department of Endocrinology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Jinye Liang
Jinye Liang
Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Weida Li
Weida Li
Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Chao Zhang
Chao Zhang
Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Zhen-Ning Zhang
Zhen-Ning Zhang
Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Bing Luan
Bing Luan
Department of Endocrinology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
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& Karin 2012 ). Disrupted lipid metabolism including fatty acid oxidation and de novo lipogenesis in liver results in the development of hepatic steatosis and contributes to the development of hepatic insulin resistance ( Marchesini et al . 2003
George Bikopoulos
George Bikopoulos
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Aurelio da Silva Pimenta
Aurelio da Silva Pimenta
Department of Laboratory Medicine and Pathobiology, School of Kinesiology and Health Science, Department of Physiology, Clinical Islet Transplant Program, Department of Agricultural, 1 King's College Circle, University of Toronto, Toronto, Canada M5S 1A8
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Simon C Lee
Simon C Lee
Department of Laboratory Medicine and Pathobiology, School of Kinesiology and Health Science, Department of Physiology, Clinical Islet Transplant Program, Department of Agricultural, 1 King's College Circle, University of Toronto, Toronto, Canada M5S 1A8
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Jonathan R Lakey
Jonathan R Lakey
Department of Laboratory Medicine and Pathobiology, School of Kinesiology and Health Science, Department of Physiology, Clinical Islet Transplant Program, Department of Agricultural, 1 King's College Circle, University of Toronto, Toronto, Canada M5S 1A8
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Sandy D Der
Sandy D Der
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Catherine B Chan
Catherine B Chan
Department of Laboratory Medicine and Pathobiology, School of Kinesiology and Health Science, Department of Physiology, Clinical Islet Transplant Program, Department of Agricultural, 1 King's College Circle, University of Toronto, Toronto, Canada M5S 1A8
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Rolando Bacis Ceddia
Rolando Bacis Ceddia
Department of Laboratory Medicine and Pathobiology, School of Kinesiology and Health Science, Department of Physiology, Clinical Islet Transplant Program, Department of Agricultural, 1 King's College Circle, University of Toronto, Toronto, Canada M5S 1A8
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Michael B Wheeler
Michael B Wheeler
Department of Laboratory Medicine and Pathobiology, School of Kinesiology and Health Science, Department of Physiology, Clinical Islet Transplant Program, Department of Agricultural, 1 King's College Circle, University of Toronto, Toronto, Canada M5S 1A8
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Maria Rozakis-Adcock
Maria Rozakis-Adcock
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pathways that lead to oxidative stress, reduced β-cell insulin content, and inhibition of GSIS. Materials and Methods Fatty acid preparation OA bound to fatty acid-free BSA was prepared by stirring 4 mmol/l OA with 5% (wt/vol) BSA in Krebs–Ringer HEPES
Giselle Adriana Abruzzese
Giselle Adriana Abruzzese
Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
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Maria Florencia Heber
Maria Florencia Heber
Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
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Silvana Rocio Ferreira
Silvana Rocio Ferreira
Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
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Leandro Martin Velez
Leandro Martin Velez
Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
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Roxana Reynoso
Roxana Reynoso
Laboratorio de Endocrinología, Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
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Omar Pedro Pignataro
Omar Pedro Pignataro
Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
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Alicia Beatriz Motta
Alicia Beatriz Motta
Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
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. Regarding fatty acid oxidation pathways, we found that Pparα mRNA levels showed no differences between the control and PHov groups but were decreased in PHanov ( Fig. 3H , P <0.01), and that Pgc1α levels were lower in both PH animals than in controls
Fausto Bogazzi
Fausto Bogazzi
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Francesco Raggi
Francesco Raggi
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Federica Ultimieri
Federica Ultimieri
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Dania Russo
Dania Russo
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Aldo D'Alessio
Aldo D'Alessio
Department of Endocrinology and Metabolism, Department of Chemistry and Industrial Chemistry, University of Pisa, Ospedale Cisanello, Via Paradisa 2, 56124 Pisa, Italy
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Antonella Manariti
Antonella Manariti
Department of Endocrinology and Metabolism, Department of Chemistry and Industrial Chemistry, University of Pisa, Ospedale Cisanello, Via Paradisa 2, 56124 Pisa, Italy
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Sandra Brogioni
Sandra Brogioni
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Luca Manetti
Luca Manetti
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Enio Martino
Enio Martino
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different energy requirements. Energy metabolism in normal hearts depends on ATP production from mitochondrial oxidation of glucose and fatty acids (FA; Taegtmeyer 1994 , Stanley & Chandler 2002 ). FA oxidation is the main cardiac energy source accounting
Hannah M Eggink
Hannah M Eggink
Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
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Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
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Lauren L Tambyrajah
Lauren L Tambyrajah
Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands
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Rosa van den Berg
Rosa van den Berg
Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands
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Isabel M Mol
Isabel M Mol
Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands
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Jose K van den Heuvel
Jose K van den Heuvel
Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands
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Martijn Koehorst
Martijn Koehorst
Department of Pediatrics and Laboratory Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
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Albert K Groen
Albert K Groen
Department of Pediatrics and Laboratory Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
Department of Vascular Medicine, Amsterdam Diabetes Centre, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
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Department of Vascular Medicine, Amsterdam Diabetes Centre, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
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Anita Boelen
Anita Boelen
Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
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Andries Kalsbeek
Andries Kalsbeek
Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
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Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
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Johannes A Romijn
Johannes A Romijn
Department of Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
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Patrick C N Rensen
Patrick C N Rensen
Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands
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Sander Kooijman
Sander Kooijman
Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands
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Maarten R Soeters
Maarten R Soeters
Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
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infusion induces browning in white adipose tissue Since we observed that tLCA enhanced fatty acid oxidation and reduced total fat mass, we next investigated the effects of i.c.v. administration of tLCA on adipose tissue morphology, notably sWAT and gWAT
Andrea Anedda
Andrea Anedda
Department of Cellular and Molecular Physiopathology, Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
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Eduardo Rial
Eduardo Rial
Department of Cellular and Molecular Physiopathology, Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
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M Mar González-Barroso
M Mar González-Barroso
Department of Cellular and Molecular Physiopathology, Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
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and β-oxidation, which would imply that there is no release of fatty acids and that they are oxidized within the adipocyte. In this respect, it must be emphasized that metformin also causes an increase in mitochondrial mass ( Lenhard et al . 1997
