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P Nguyen Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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S Khurana Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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H Peltsch Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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J Grandbois Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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J Eibl Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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J Crispo Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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D Ansell Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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T C Tai Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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observed that exposure to high doses of glucocorticoids (GCs) during fetal development, generated either as a consequence of maternal stressors or administered antenatally also reduces birth weight and leads to development of essential hypertension later in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0244
Volume/Issue:
Volume 227: Issue 2
Free access
Thanh Q Dang Department of Biology, Faculty of Science York University, Toronto, Canada

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Nanyoung Yoon Department of Biology, Faculty of Science York University, Toronto, Canada

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Helen Chasiotis Department of Biology, Faculty of Science York University, Toronto, Canada

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Emily C Dunford School of Kinesiology and Health Science, Faculty of Health and Muscle Health Research Center, York University, Toronto, Canada

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Qilong Feng Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, PA, USA

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Pingnian He Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, PA, USA

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Michael C Riddell School of Kinesiology and Health Science, Faculty of Health and Muscle Health Research Center, York University, Toronto, Canada

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Scott P Kelly Department of Biology, Faculty of Science York University, Toronto, Canada

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Gary Sweeney Department of Biology, Faculty of Science York University, Toronto, Canada

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concentrations of the hormone are significantly lower in the target tissue than those in the circulation ( Kolka & Bergman 2012 ). Glucocorticoids are among the most commonly prescribed anti-inflammatory and immunosuppressive medications worldwide ( Clark

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0363
Volume/Issue:
Volume 234: Issue 2
Free access
Claire L Wood Division of Developmental Biology, Roslin Institute, University of Edinburgh, Edinburgh, UK

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Ondrej Soucek Department of Paediatrics, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic
Department of Women’s and Children’s Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden

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Sze C Wong Developmental Endocrinology Research Group, School of Medicine, University of Glasgow, Glasgow, UK

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Farasat Zaman Department of Women’s and Children’s Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden

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Colin Farquharson Division of Developmental Biology, Roslin Institute, University of Edinburgh, Edinburgh, UK

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Lars Savendahl Department of Women’s and Children’s Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden

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S Faisal Ahmed Developmental Endocrinology Research Group, School of Medicine, University of Glasgow, Glasgow, UK

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Introduction and background It is estimated that, at any one time, over 250,000 people are exposed to systemic glucocorticoids (GCs); approximately 10% of children will require GCs at some stage during their childhood ( Mushtaq & Ahmed 2002

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0361
Volume/Issue:
Volume 236: Issue 1
Free access
Alberto Dinarello Department of Biology, University of Padova, Padova, Italy

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Giorgio Licciardello Department of Biology, University of Padova, Padova, Italy

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Camilla Maria Fontana Department of Biology, University of Padova, Padova, Italy

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Natascia Tiso Department of Biology, University of Padova, Padova, Italy

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Francesco Argenton Department of Biology, University of Padova, Padova, Italy

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Luisa Dalla Valle Department of Biology, University of Padova, Padova, Italy

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The glucocorticoid signaling pathways Steroid hormones are lipophilic and low-molecular weight compounds broadly involved in endocrine signaling, thus, able to trigger systemic effects through bloodstream circulation. All steroid hormones

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0173
Volume/Issue:
Volume 247: Issue 3
Free access
Alex Rafacho Department of Physiological Sciences, Department of Clinical Science and Education, Institute of Bioengineering and the Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Center of Biological Sciences, Federal University of Santa Catarina (UFSC), 88040-900, Florianópolis, SC, Brazil

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Henrik Ortsäter Department of Physiological Sciences, Department of Clinical Science and Education, Institute of Bioengineering and the Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Center of Biological Sciences, Federal University of Santa Catarina (UFSC), 88040-900, Florianópolis, SC, Brazil

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Angel Nadal Department of Physiological Sciences, Department of Clinical Science and Education, Institute of Bioengineering and the Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Center of Biological Sciences, Federal University of Santa Catarina (UFSC), 88040-900, Florianópolis, SC, Brazil

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Ivan Quesada Department of Physiological Sciences, Department of Clinical Science and Education, Institute of Bioengineering and the Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Center of Biological Sciences, Federal University of Santa Catarina (UFSC), 88040-900, Florianópolis, SC, Brazil

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Introduction Glucocorticoids (GCs), such as cortisol in humans and corticosterone in rodents, are produced in the adrenal cortex and play a key role in the regulation of glucose homeostasis and nutrient metabolism. Synthetic GCs, which include

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0373
Volume/Issue:
Volume 223: Issue 3
Free access
Dawn E W Livingstone Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Emma M Di Rollo Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Chenjing Yang Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Lucy E Codrington Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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John A Mathews Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Madina Kara Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Katherine A Hughes Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Christopher J Kenyon Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Brian R Walker Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Ruth Andrew Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Introduction Activation of the hypothalamic–pituitary–adrenal (HPA) axis is a vital component of the stress response, driving production of glucocorticoid hormones (cortisol in humans, corticosterone in rodents) that mediate essential adaptations of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0563
Volume/Issue:
Volume 222: Issue 2
Open access
Alberto González-Mayoral INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France
Paris Brain Institue-Institut du Cerveau, CNRS UMR7225, INSERM U1127, Hôpital de la Pitié Salpêtrière, Paris, France

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Axel Eid INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France
INSERM UMR 1195 (DHNS), Faculty of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France

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Razmig Derounian INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France

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Virginia Sofia Campanella INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France

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Andreia da Silva Ramos INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France

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Romy El Khoury INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France

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Charbel Massaad INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France

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Damien Le Menuet INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France

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regeneration. Glucocorticoid (GC) hormones are also able to promote remyelination and nerve regeneration after injury ( Hughes 2002 , Morisaki et al. 2010 , Feng & Yuan 2015 ) although it is not clear if their effects are due to their anti

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0334
Volume/Issue:
Volume 258: Issue 2
Restricted access
Jethro S Johnson Computational Genomics Analysis and Training, Medical Research Council-Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

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Monica N Opiyo University/BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, Edinburgh, UK

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Marian Thomson Edinburgh Genomics, Ashworth Laboratories, University of Edinburgh, Edinburgh, UK

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Karim Gharbi Edinburgh Genomics, Ashworth Laboratories, University of Edinburgh, Edinburgh, UK

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Jonathan R Seckl University/BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, Edinburgh, UK

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Andreas Heger Computational Genomics Analysis and Training, Medical Research Council-Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

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Karen E Chapman University/BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, Edinburgh, UK

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) contributes to intracellular glucocorticoid action by catalysing the conversion of inactive to active forms of the principal glucocorticoids found in humans (cortisone to cortisol) and mice (11-dehydrocorticosterone to corticosterone). Whilst widely

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0578
Volume/Issue:
Volume 232: Issue 2
Open access
Tracey A Quinn Monash Institute of Medical Research, The Florey Institute of Neuroscience and Mental Health, School of Biomedical Sciences, Department of Obstetrics and Gynaecology, The Ritchie Centre, Monash University, 27‐31 Wright Street, Clayton, Victoria 3168, Australia

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Udani Ratnayake Monash Institute of Medical Research, The Florey Institute of Neuroscience and Mental Health, School of Biomedical Sciences, Department of Obstetrics and Gynaecology, The Ritchie Centre, Monash University, 27‐31 Wright Street, Clayton, Victoria 3168, Australia

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Margie Castillo-Melendez Monash Institute of Medical Research, The Florey Institute of Neuroscience and Mental Health, School of Biomedical Sciences, Department of Obstetrics and Gynaecology, The Ritchie Centre, Monash University, 27‐31 Wright Street, Clayton, Victoria 3168, Australia

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Karen M Moritz Monash Institute of Medical Research, The Florey Institute of Neuroscience and Mental Health, School of Biomedical Sciences, Department of Obstetrics and Gynaecology, The Ritchie Centre, Monash University, 27‐31 Wright Street, Clayton, Victoria 3168, Australia

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Hayley Dickinson Monash Institute of Medical Research, The Florey Institute of Neuroscience and Mental Health, School of Biomedical Sciences, Department of Obstetrics and Gynaecology, The Ritchie Centre, Monash University, 27‐31 Wright Street, Clayton, Victoria 3168, Australia

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David W Walker Monash Institute of Medical Research, The Florey Institute of Neuroscience and Mental Health, School of Biomedical Sciences, Department of Obstetrics and Gynaecology, The Ritchie Centre, Monash University, 27‐31 Wright Street, Clayton, Victoria 3168, Australia
Monash Institute of Medical Research, The Florey Institute of Neuroscience and Mental Health, School of Biomedical Sciences, Department of Obstetrics and Gynaecology, The Ritchie Centre, Monash University, 27‐31 Wright Street, Clayton, Victoria 3168, Australia

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glucocorticoids. At high concentrations, the free fraction of circulating maternal glucocorticoids can cross the placental and fetal blood–brain barriers ( Zarrow et al . 1970 , Herbert 1998 ), where they affect fetal hypothalamic–pituitary–adrenal (HPA

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0514
Volume/Issue:
Volume 221: Issue 2
Free access
Elisa Villalobos University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Allende Miguelez-Crespo University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Ruth A Morgan University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Scotland’s Rural College, The Roslin Institute, Easter Bush Campus, United Kingdom

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Lisa Ivatt University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Mhairi Paul University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Joanna P Simpson University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Natalie Z M Homer University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Dominic Kurian The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom

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Judit Aguilar The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom

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Rachel A Kline The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom

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Thomas M Wishart The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom

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Nicholas M Morton University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Centre for Systems Health and Integrated Metabolic Research, Nottingham Trent University, Nottingham, United Kingdom

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Roland H Stimson University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Ruth Andrew University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Brian R Walker University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Mark Nixon University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Introduction Glucocorticoids are required to maintain glucose and lipid homeostasis in times of physiological stress, ensuring an adequate fuel supply for the body ( Kuo et al. 2015 ). In key metabolic tissues such as adipose tissue

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-24-0024
Volume/Issue:
Volume 262: Issue 2
Open access