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A J W Hsueh Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California, 94305-5317, USA
Endocrinology Unit and EA 1533, University Pierre et Marie Curie, Genetics of Human Reproduction, Hôpital Saint-Antoine, 184 rue de Fg St Antoine, 75012, Paris, France

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P Bouchard Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California, 94305-5317, USA
Endocrinology Unit and EA 1533, University Pierre et Marie Curie, Genetics of Human Reproduction, Hôpital Saint-Antoine, 184 rue de Fg St Antoine, 75012, Paris, France

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I Ben-Shlomo Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California, 94305-5317, USA
Endocrinology Unit and EA 1533, University Pierre et Marie Curie, Genetics of Human Reproduction, Hôpital Saint-Antoine, 184 rue de Fg St Antoine, 75012, Paris, France

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In 1905, Ernest Starling published four landmark Croonian lectures, entitled The chemical correlation of the functions of the body. Dr Starling used the term hormone for the first time in his initial lecture, The chemical control of the functions

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.1.06372
Volume/Issue:
Volume 187: Issue 3
Free access
John A H Wass Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Old Road, Headington, Oxford OX3 7LJ, UK

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Raghava Reddy Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Old Road, Headington, Oxford OX3 7LJ, UK

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Introduction Much has been written about the effects of growth hormone (GH) replacement therapy in GH-deficient human subjects on growth, body composition, cardiovascular risk factors, bone and muscle development and quality of life. When properly

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0126
Volume/Issue:
Volume 207: Issue 2
Free access
John T Potts Endocrine Unit, Department of Medicine, The Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Room 4013, Charlestown, Boston, Massachusetts 02114, USA

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be described over the last hundred years. These include determination of the physiological function of the parathyroids, the pathophysiology due to hormone excess or deficiency, chemical characterization and synthesis of parathyroid hormone (PTH) and

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.1.06057
Volume/Issue:
Volume 187: Issue 3
Free access
J Patel School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia
School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia

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K Landers School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia

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H Li School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia

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R H Mortimer School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia
School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia
School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia

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K Richard School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia
School of Medicine, Conjoint Endocrine Laboratory, Disciplines of Medicine, The University of Queensland, Herston, 4006 Brisbane, Queensland, Australia

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development was made very much later ( Cranefield 1962 , Morreale de Escobar et al . 2004 ). Thyroid hormones (thyroxine (T 4 ) and triiodothyronine (T 3 )) are essential for the development and maintenance of normal physiological processes, especially

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0444
Volume/Issue:
Volume 209: Issue 1
Free access
Cyril S Anyetei-Anum Department of Biology, College of William and Mary, Williamsburg, Virginia, USA

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Vincent R Roggero Department of Biology, College of William and Mary, Williamsburg, Virginia, USA

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Lizabeth A Allison Department of Biology, College of William and Mary, Williamsburg, Virginia, USA

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Introduction Thyroid hormone is essential for many diverse processes in nearly all vertebrate tissues, and abnormal thyroid hormone signaling underpins several human diseases ( Laudet & Gronemeyer 2002 , Chen et al . 2013 , Kim & Cheng 2013

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0708
Volume/Issue:
Volume 237: Issue 1
Free access
F Labrie Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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V Luu-The Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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A Bélanger Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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S-X Lin Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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J Simard Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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G Pelletier Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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C Labrie Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center (CRCHUL) and Laval University, Québec City, Québec G1 V 4 G2, Canada

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intracellular hormone formation and action has been called intracrinology ( Labrie et al. 1988 , Labrie 1991 ) (Fig. 3 ). This situation of a high secretion rate of adrenal precursor sex steroids in men and women is thus completely different from all animal

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.1.06264
Volume/Issue:
Volume 187: Issue 2
Free access
Mone Zaidi The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Maria I New The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Harry C Blair The Pittsburgh VA Medical Center and Departments of Pathology and of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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Alberta Zallone Department of Histology, University of Bari, Bari, Italy

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Ramkumarie Baliram The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Terry F Davies The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Christopher Cardozo The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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James Iqbal The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Li Sun The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Clifford J Rosen Maine Medical Center Research Institute, Scarborough, Maine, USA

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Tony Yuen The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Introduction It has become increasingly clear that pituitary hormones that have traditionally been seen as regulators of single bodily processes, including endocrine functions, have additional roles in physiology. The global deletion of these

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0680
Volume/Issue:
Volume 237: Issue 3
Free access
J C Sousa Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
Institute for Molecular and Cell Biology, Rua do Campo Alegre, Porto, Portugal
ICBAS, University of Porto, Largo Professor Abel Salazar, Porto, Portugal
Molecular Endocrinology Unit, Instituto de Investigaciones Biomédicas Alberto Sols, CSIC & UAM, Madrid, Spain
Department of Production & Systems Engineering, University of Minho, Campus Gualtar, Braga, Portugal

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G Morreale de Escobar Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
Institute for Molecular and Cell Biology, Rua do Campo Alegre, Porto, Portugal
ICBAS, University of Porto, Largo Professor Abel Salazar, Porto, Portugal
Molecular Endocrinology Unit, Instituto de Investigaciones Biomédicas Alberto Sols, CSIC & UAM, Madrid, Spain
Department of Production & Systems Engineering, University of Minho, Campus Gualtar, Braga, Portugal

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P Oliveira Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
Institute for Molecular and Cell Biology, Rua do Campo Alegre, Porto, Portugal
ICBAS, University of Porto, Largo Professor Abel Salazar, Porto, Portugal
Molecular Endocrinology Unit, Instituto de Investigaciones Biomédicas Alberto Sols, CSIC & UAM, Madrid, Spain
Department of Production & Systems Engineering, University of Minho, Campus Gualtar, Braga, Portugal

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M J Saraiva Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
Institute for Molecular and Cell Biology, Rua do Campo Alegre, Porto, Portugal
ICBAS, University of Porto, Largo Professor Abel Salazar, Porto, Portugal
Molecular Endocrinology Unit, Instituto de Investigaciones Biomédicas Alberto Sols, CSIC & UAM, Madrid, Spain
Department of Production & Systems Engineering, University of Minho, Campus Gualtar, Braga, Portugal

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J A Palha Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
Institute for Molecular and Cell Biology, Rua do Campo Alegre, Porto, Portugal
ICBAS, University of Porto, Largo Professor Abel Salazar, Porto, Portugal
Molecular Endocrinology Unit, Instituto de Investigaciones Biomédicas Alberto Sols, CSIC & UAM, Madrid, Spain
Department of Production & Systems Engineering, University of Minho, Campus Gualtar, Braga, Portugal

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thyroid hormone homeostasis and hormone delivery to the brain ( Dickson et al. 1987 , Dratman et al. 1991 , Chanoine et al. 1992 ). However, studies in a TTR-null mouse strain revealed that despite a 50% decrease in total T 4 plasma levels

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06406
Volume/Issue:
Volume 187: Issue 2
Free access
R L Bogorad Laboratory of Endocrinology, Faculty of Biology, Lomonosov Moscow State University, Vorob’ev Hills, 119992, Moscow, Russian Federation
Laboratory of Hormones and Receptors, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova Str., 119991, Moscow, Russian Federation

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T Y Ostroukhova Laboratory of Endocrinology, Faculty of Biology, Lomonosov Moscow State University, Vorob’ev Hills, 119992, Moscow, Russian Federation
Laboratory of Hormones and Receptors, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova Str., 119991, Moscow, Russian Federation

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A N Orlova Laboratory of Endocrinology, Faculty of Biology, Lomonosov Moscow State University, Vorob’ev Hills, 119992, Moscow, Russian Federation
Laboratory of Hormones and Receptors, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova Str., 119991, Moscow, Russian Federation

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P M Rubtsov Laboratory of Endocrinology, Faculty of Biology, Lomonosov Moscow State University, Vorob’ev Hills, 119992, Moscow, Russian Federation
Laboratory of Hormones and Receptors, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova Str., 119991, Moscow, Russian Federation

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O V Smirnova Laboratory of Endocrinology, Faculty of Biology, Lomonosov Moscow State University, Vorob’ev Hills, 119992, Moscow, Russian Federation
Laboratory of Hormones and Receptors, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova Str., 119991, Moscow, Russian Federation

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expression: the level of PrlR is higher than in most other tissues, and this mainly involves the short isoform since the long PrlR is 10% of total ( Nagano & Kelly 1994 ). The total level of PrlR in hepatocytes is regulated by sex hormones: oestrogens

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06468
Volume/Issue:
Volume 188: Issue 2
Free access
Aline Cordeiro Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Avenida Carlos Chagas Filho, 373, Bloco G, Cidade Universitária - Ilha do Fundão, Rio de Janeiro - RJ 21941-902, Brazil

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Luana Lopes Souza Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Avenida Carlos Chagas Filho, 373, Bloco G, Cidade Universitária - Ilha do Fundão, Rio de Janeiro - RJ 21941-902, Brazil

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Marcelo Einicker-Lamas Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Avenida Carlos Chagas Filho, 373, Bloco G, Cidade Universitária - Ilha do Fundão, Rio de Janeiro - RJ 21941-902, Brazil

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Carmen Cabanelas Pazos-Moura Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Avenida Carlos Chagas Filho, 373, Bloco G, Cidade Universitária - Ilha do Fundão, Rio de Janeiro - RJ 21941-902, Brazil

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Thyroid hormone effects on lipid metabolism The thyroid hormones, triiodothyronine (T 3 ) and thyroxine (T 4 ), modulate several physiological processes in organisms and are critical in the growth, development, differentiation and maintenance of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0542
Volume/Issue:
Volume 216: Issue 3
Free access