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Mohamed Asrih Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospital, Rue Gabrielle‐Perret‐Gentil 4, 1211 Genève 14, Switzerland

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François R Jornayvaz Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospital, Rue Gabrielle‐Perret‐Gentil 4, 1211 Genève 14, Switzerland

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, insulin resistance, hypertension, and dyslipidemia, suggesting that NAFLD might be considered as the liver manifestation of the metabolic syndrome ( Marchesini et al . 2001 , Adams et al . 2005 ). The metabolic syndrome is a leading cause of mortality

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0201
Volume/Issue:
Volume 218: Issue 3
Free access
Sergio Di Meo Dipartimento di Biologia, Università di Napoli ‘Federico II’, Napoli, Italy

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Susanna Iossa Dipartimento di Biologia, Università di Napoli ‘Federico II’, Napoli, Italy

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Paola Venditti Dipartimento di Biologia, Università di Napoli ‘Federico II’, Napoli, Italy

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increased the most in obese people, compared with lean ones, is type 2 diabetes mellitus (T2DM), a condition resulting from the metabolic changes associated with excess fat. A pivotal role in T2DM development is played by insulin resistance (IR) that is

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0186
Volume/Issue:
Volume 234: Issue 3
Free access
Maristela Mitiko Okamoto
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Gabriel Forato Anhê Department of Physiology and Biophysics, Department of Pharmacology, Diabetes Unit, Institute of Biomedical Sciences, University of São Paulo, Avenida Prof. Lineu Prestes, 1524, 05505-900 São Paulo (SP), Brazil

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Robinson Sabino-Silva
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Milano Felipe dos Santos Ferreira Marques
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Helayne Soares Freitas
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Rosana Cristina Tieko Mori
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Karla Fabiana S Melo Department of Physiology and Biophysics, Department of Pharmacology, Diabetes Unit, Institute of Biomedical Sciences, University of São Paulo, Avenida Prof. Lineu Prestes, 1524, 05505-900 São Paulo (SP), Brazil

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Ubiratan Fabres Machado
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resistance is involved in the pathogenesis of type 2 diabetes mellitus (T2DM; Björnholm & Zierath 2005 ). In type 1 diabetes mellitus (T1DM), apart from its well-known pathogenesis, insulin resistance has also been described in both undertreated

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0105
Volume/Issue:
Volume 211: Issue 1
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Rubén Marín-Juez
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Susanne Jong-Raadsen
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Shuxin Yang ZF‐Screens BV, Institute of Biology, J.H. Oortweg 19, 2333 CH Leiden, The Netherlands

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Herman P Spaink ZF‐Screens BV, Institute of Biology, J.H. Oortweg 19, 2333 CH Leiden, The Netherlands

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insulin resistance in mammals. For instance, a twofold increase in plasma insulin levels can induce insulin resistance in mice, resembling the pattern in insulin-resistant patients with pathological obesity or type 2 diabetes who show similar increases in

Article Type:
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DOI:
https://doi.org/10.1530/JOE-14-0178
Volume/Issue:
Volume 222: Issue 2
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Edward Park
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Victor Wong
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Xinyu Guan
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Andrei I Oprescu
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Adria Giacca
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Introduction Numerous studies have established a close relationship between obesity, insulin resistance, and type 2 diabetes. This link is attributed to greater release of various adipocyte products, such as cytokines, resistin, and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0005
Volume/Issue:
Volume 195: Issue 2
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Li Li Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA

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Xiaohua Li Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA
Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA

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Wenjun Zhou Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA
Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA

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Joseph L Messina Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA
Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA

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decreased response to insulin ( Lillioja et al . 1988 , Pessin & Saltiel 2000 , Shulman 2000 , Saltiel & Kahn 2001 ). Insulin resistance can occur through multiple mechanisms, including a change of insulin receptor (IR) number or function or defects in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0559
Volume/Issue:
Volume 217: Issue 2
Free access
Claudia E Robert-Cooperman
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Grace C Dougan Department of Cell Biology, Department of Pediatrics, Microbiology and Molecular Biology, University of South Florida, 4202 East Fowler Avenue, BSF 206, Tampa, Florida 33620, USA

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Shari L Moak
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Mark G Athanason
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Melanie N Kuehl
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Harris Bell-Temin
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Stanley M Stevens Jr
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Brant R Burkhardt
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. 2 A. The difference in fasting glycemia was diminished over time due to WT group (6 months of age) having increased glucose levels potentially attributed to age-dependent insulin resistance ( Fig. 2 A). Significantly higher ( P <0.001) glycemic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0338
Volume/Issue:
Volume 220: Issue 3
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Medha Sharma Kusuma School of Biological Sciences, Indian Institute of Technology, Delhi, New Delhi, India

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Yamini Yadav Kusuma School of Biological Sciences, Indian Institute of Technology, Delhi, New Delhi, India

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Chinmoy Sankar Dey Kusuma School of Biological Sciences, Indian Institute of Technology, Delhi, New Delhi, India

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defects in this insulin signal transduction causes insulin resistance, which leads to various metabolic diseases, with type 1, 2, and 3 diabetes leading among them. Furthering the complication of metabolic diseases is the inability of peripheral insulin

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0151
Volume/Issue:
Volume 260: Issue 1
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Qiuhua Yang Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Jiean Xu Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Qian Ma Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Zhiping Liu Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Yaqi Zhou State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University, Shenzhen, China

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Yongfeng Cai State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University, Shenzhen, China

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Xiaoxiao Mao Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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David Stepp Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Neal Weintraub Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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David J Fulton Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Mei Hong State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University, Shenzhen, China

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Yuqing Huo Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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-fat diet (HFD)-induced insulin resistance. Saturated fatty acids are major contributors to the process of high-fat feeding, causing insulin resistance ( Nakamura et al. 2009 ). It has been well demonstrated that palmitate induces inflammation in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0524
Volume/Issue:
Volume 250: Issue 3
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Hamza Amine Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France
Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France
Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Yacir Benomar Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France
Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Adil Haimeur Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Hafida Messaouri Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Nadia Meskini Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Mohammed Taouis Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France
Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Introduction Insulin resistance is a major risk factor for type 2 diabetes that is often associated with metabolic syndrome including obesity, cardiovascular diseases and dyslipidemia. The alarming worldwide augmentation of type 2 diabetes becomes a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0316
Volume/Issue:
Volume 228: Issue 1
Free access