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Manesh Chittezhath Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore

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Cho M M Wai Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore

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Vanessa S Y Tay Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore

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Minni Chua Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore
Singapore Eye Research Institute (SERI), Singapore General Hospital, Singapore, Singapore

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Sarah R Langley Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore

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Yusuf Ali Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore
Singapore Eye Research Institute (SERI), Singapore General Hospital, Singapore, Singapore

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. However, pancreatic islets contain other different cell types besides β-cells (e.g. other endocrine cells, vascular endothelial cells, sympathetic neurons, as well as macrophages). These other cell types may be the ones that are responsive to TLR ligands

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0131
Volume/Issue:
Volume 247: Issue 1
Restricted access
L Banaei-Bouchareb INSERM U457, Robert Debré Hospital, Paris, France
EMI0363 Necker University, Paris, France
Pathology Department, Robert Debré Hospital, 3EA3102 Paris VII University, Paris, France
Endocrinology Department, Robert Debré Hospital, Paris, France
Paediatric Endocrinology Department, Necker Enfants Malades Hospital, Paris, France

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M Peuchmaur INSERM U457, Robert Debré Hospital, Paris, France
EMI0363 Necker University, Paris, France
Pathology Department, Robert Debré Hospital, 3EA3102 Paris VII University, Paris, France
Endocrinology Department, Robert Debré Hospital, Paris, France
Paediatric Endocrinology Department, Necker Enfants Malades Hospital, Paris, France

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P Czernichow INSERM U457, Robert Debré Hospital, Paris, France
EMI0363 Necker University, Paris, France
Pathology Department, Robert Debré Hospital, 3EA3102 Paris VII University, Paris, France
Endocrinology Department, Robert Debré Hospital, Paris, France
Paediatric Endocrinology Department, Necker Enfants Malades Hospital, Paris, France

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M Polak INSERM U457, Robert Debré Hospital, Paris, France
EMI0363 Necker University, Paris, France
Pathology Department, Robert Debré Hospital, 3EA3102 Paris VII University, Paris, France
Endocrinology Department, Robert Debré Hospital, Paris, France
Paediatric Endocrinology Department, Necker Enfants Malades Hospital, Paris, France

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leukocytes. The present study had three objectives: 1) to monitor the presence of CD45RA-cells in the mesenchyme of the human developing pancreas; 2) to characterize their phenotype and determine whether they are macrophages, leukocytes otherwise

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06225
Volume/Issue:
Volume 188: Issue 3
Free access
Simin Younesi School of Health and Biomedical Sciences RMIT University, Melbourne, Victoria, Australia

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Alita Soch School of Health and Biomedical Sciences RMIT University, Melbourne, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, Microscopy Facility, Melbourne, Victoria, Australia

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Luba Sominsky School of Health and Biomedical Sciences RMIT University, Melbourne, Victoria, Australia
Barwon Health Laboratory, Barwon Health, University Hospital, Geelong, Victoria, Australia
Institute for Physical and Mental Health and Clinical Transformation, School of Medicine, Deakin University, Geelong, Victoria, Australia

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Sarah J Spencer School of Health and Biomedical Sciences RMIT University, Melbourne, Victoria, Australia
ARC Centre of Excellence for Nanoscale Biophotonics, RMIT University, Melbourne, Victoria, Australia

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further alter CNS function in the absence of microglia. Nevertheless, we have also shown that depletion of microglia, circulating monocytes, and ovarian macrophages in Cx3cr1-Dtr rats has no sustained effects on baseline ovarian follicle health if the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0404
Volume/Issue:
Volume 254: Issue 2
Restricted access
Maayan Vatarescu The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Sapir Bechor The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Yulia Haim The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Tal Pecht The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Tanya Tarnovscki The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Noa Slutsky The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Ori Nov The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Hagit Shapiro The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Avishai Shemesh The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University, Beer-Sheva, Israel

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Angel Porgador The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University, Beer-Sheva, Israel

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Nava Bashan The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Assaf Rudich The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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inflammation (particularly macrophage infiltration) characterizes obese persons who develop insulin resistance ( Harman-Boehm et al . 2007 ), but to a much lesser degree age, sex and BMI-matched obese persons who remain insulin sensitive ( Kloting et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0007
Volume/Issue:
Volume 233: Issue 3
Open access
Xiaohui Wang
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Yuxia Chen
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Yan Wang
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Xiaoyan Zhu
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Yuanyuan Ma
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Shimin Zhang Department of Pathophysiology, American Registry of Pathology at Armed Forces Institute of Pathology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People's Republic of China

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Jian Lu
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cytokine production in macrophages ( Distelhorst 2002 , Frankfurt & Rosen 2004 ). Macrophages also play a key role in the immune and inflammatory process, mainly acting as antigen-processing/presenting cells and sources of inflammatory cytokines. Although

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0340
Volume/Issue:
Volume 200: Issue 1
Free access
Michael P Corcoran Lipid Metabolism Laboratory, Vascular Biology Laboratory, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA

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Mohsen Meydani Lipid Metabolism Laboratory, Vascular Biology Laboratory, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA

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Alice H Lichtenstein Lipid Metabolism Laboratory, Vascular Biology Laboratory, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA

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Ernst J Schaefer Lipid Metabolism Laboratory, Vascular Biology Laboratory, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA

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Alice Dillard Lipid Metabolism Laboratory, Vascular Biology Laboratory, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA

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Stefania Lamon-Fava Lipid Metabolism Laboratory, Vascular Biology Laboratory, Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA

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local inflammation ( Brown & Goldstein 1983 ). Recruited monocytes differentiate into macrophages and begin to take up oxidized lipoproteins, leading to the formation of foam cells. Foam cells are a primary component of early atheroma lesion formation

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0057
Volume/Issue:
Volume 206: Issue 2
Free access
L E Nicol Pediatrics, Division of Neurosciences, Pape Pediatric Research Institute

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W F Grant Pediatrics, Division of Neurosciences, Pape Pediatric Research Institute

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S M Comstock Pediatrics, Division of Neurosciences, Pape Pediatric Research Institute

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M L Nguyen Pediatrics, Division of Neurosciences, Pape Pediatric Research Institute

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M S Smith Pediatrics, Division of Neurosciences, Pape Pediatric Research Institute

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K L Grove Pediatrics, Division of Neurosciences, Pape Pediatric Research Institute

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D L Marks Pediatrics, Division of Neurosciences, Pape Pediatric Research Institute
Pediatrics, Division of Neurosciences, Pape Pediatric Research Institute

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(Arg1; Rh02826373_m1) M1- and M2-activated macrophages respectively from the same cDNA as mentioned earlier. Quantitative PCRs were run on an ABI 7300 (Applied Biosystems), using TaqMan universal PCR master mix TaqMan master mix in a 10 μl reaction

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0424
Volume/Issue:
Volume 217: Issue 2
Free access
Hyo Youl Moon
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Parkyong Song BioSignal Network Laboratory, Division of Molecular and Life Sciences, Lee Gil Ya Cancer and Diabetes Institute, School of Nano-Biotechnology and Chemical Engineering, Ulsan National Institute of Science and Technology, Engineering Building 104, 689-805 Ulsan, Republic of Korea

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Cheol Soo Choi BioSignal Network Laboratory, Division of Molecular and Life Sciences, Lee Gil Ya Cancer and Diabetes Institute, School of Nano-Biotechnology and Chemical Engineering, Ulsan National Institute of Science and Technology, Engineering Building 104, 689-805 Ulsan, Republic of Korea

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Sung Ho Ryu BioSignal Network Laboratory, Division of Molecular and Life Sciences, Lee Gil Ya Cancer and Diabetes Institute, School of Nano-Biotechnology and Chemical Engineering, Ulsan National Institute of Science and Technology, Engineering Building 104, 689-805 Ulsan, Republic of Korea

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Pann-Ghill Suh
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) ( Ruderman & Prentki 2004 ). Based on the requirement for AMPK to alleviate hepatic steatosis, there is growing demand to identify mediators of AMPK activation in response to dynamic physiological activity. Although macrophage migration inhibitory factor (MIF

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0135
Volume/Issue:
Volume 218: Issue 3
Open access
Véronique Serre-Beinier Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Christian Toso Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Philippe Morel Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Carmen Gonelle-Gispert Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Christelle Veyrat-Durebex Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Françoise Rohner-Jeanrenaud Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Thierry Calandra Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Thierry Roger Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Richard W James Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Xavier Montet Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Léo Bühler Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Domenico Bosco Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Thierry Berney Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Introduction Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine involved in both innate and adaptive immunity. Originally described as a T-cell-derived product, MIF has now been shown to be released by numerous cell types and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0342
Volume/Issue:
Volume 206: Issue 3
Free access
Anne Q Reuwer Departments of, Vascular Medicine, Medical Biochemistry, Pathology, Experimental Immunology, INSERM, Department of Internal Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands

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Marco van Eijk Departments of, Vascular Medicine, Medical Biochemistry, Pathology, Experimental Immunology, INSERM, Department of Internal Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands

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Felicia M Houttuijn-Bloemendaal Departments of, Vascular Medicine, Medical Biochemistry, Pathology, Experimental Immunology, INSERM, Department of Internal Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands

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Chris M van der Loos Departments of, Vascular Medicine, Medical Biochemistry, Pathology, Experimental Immunology, INSERM, Department of Internal Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands

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Nike Claessen Departments of, Vascular Medicine, Medical Biochemistry, Pathology, Experimental Immunology, INSERM, Department of Internal Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands

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Peter Teeling Departments of, Vascular Medicine, Medical Biochemistry, Pathology, Experimental Immunology, INSERM, Department of Internal Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands

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John J P Kastelein Departments of, Vascular Medicine, Medical Biochemistry, Pathology, Experimental Immunology, INSERM, Department of Internal Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands

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Jörg Hamann Departments of, Vascular Medicine, Medical Biochemistry, Pathology, Experimental Immunology, INSERM, Department of Internal Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands

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Vincent Goffin Departments of, Vascular Medicine, Medical Biochemistry, Pathology, Experimental Immunology, INSERM, Department of Internal Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands

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Jan H von der Thüsen Departments of, Vascular Medicine, Medical Biochemistry, Pathology, Experimental Immunology, INSERM, Department of Internal Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands

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Marcel Th B Twickler Departments of, Vascular Medicine, Medical Biochemistry, Pathology, Experimental Immunology, INSERM, Department of Internal Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
Departments of, Vascular Medicine, Medical Biochemistry, Pathology, Experimental Immunology, INSERM, Department of Internal Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands

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Jan Aten Departments of, Vascular Medicine, Medical Biochemistry, Pathology, Experimental Immunology, INSERM, Department of Internal Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands

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by inflammatory cell infiltration, accumulation of heterogeneous macrophage populations, T-cell activation, cytokine production, and cell death, is also an integral part of the atherosclerotic process ( Packard & Libby 2008 ). In fact, all stages of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0076
Volume/Issue:
Volume 208: Issue 2
Free access