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R. G. Dyer
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Every physiology student is taught that oxytocin is released from the neurohypophysis and acts on the myoepithelial cells to effect milk ejection and on the myometrium to elicit uterine contractions. Milk ejection requires the bolus release of oxytocin, by the (approximately) synchronous discharge of the magnocellular oxytocin containing neurones in the hypothalamus, and this is initiated reflexly by the suckling stimulus applied to the nipple. During parturition also, oxytocin can be released as part of a neuroendocrine reflex when the fetus stimulates sensory nerve endings during its passage through the cervix. The reflex release of oxytocin at this time greatly aids the rapid completion of the delivery process.

All of the foregoing has been known for years and some of it for decades. During this time little progress was made in identifying any clearly defined physiological role for oxytocin during the earlier stages of parturition. Indeed maturational processes in the

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Hiroki Otsubo Department of Physiology, Laboratory of Physiology, Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan
Department of Physiology, Laboratory of Physiology, Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

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Susumu Hyodo Department of Physiology, Laboratory of Physiology, Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

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Hirofumi Hashimoto Department of Physiology, Laboratory of Physiology, Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

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Makoto Kawasaki Department of Physiology, Laboratory of Physiology, Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

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Hitoshi Suzuki Department of Physiology, Laboratory of Physiology, Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

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Takeshi Saito Department of Physiology, Laboratory of Physiology, Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

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Toyoaki Ohbuchi Department of Physiology, Laboratory of Physiology, Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

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Toru Yokoyama Department of Physiology, Laboratory of Physiology, Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

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Hiroaki Fujihara Department of Physiology, Laboratory of Physiology, Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

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Tetsuro Matsumoto Department of Physiology, Laboratory of Physiology, Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

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Yoshio Takei Department of Physiology, Laboratory of Physiology, Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

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Yoichi Ueta Department of Physiology, Laboratory of Physiology, Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

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vasopressin (AVP; Yokoi et al . 1996 ). Central administration of AM activated oxytocin (OXT)-secreting neurones in the supraoptic (SON) and the paraventricular nuclei (PVN; Serino et al . 1999 , Ueta et al . 2000 ), and markedly increased plasma OXT

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M. R. Luck
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The physiological role of ovarian oxytocin has been much debated since its (re)discovery at the beginning of the decade (Wathes, 1984). As a neuropeptide secreted in abundance from a non-neural tissue, ovarian oxytocin has been a good example of the 'ectopic' endocrinology discussed by Henderson (1987). As pointed out recently (Auletta, Jones & Flint, 1988), we are still only certain of its secretion in major quantities in domestic ruminants. For these species, much experimental evidence has accumulated at both the animal and tissue levels regarding the circumstances and mechanism of its secretion. The problem has been to define exactly what role it may play in the endocrinology of the reproductive cycle. Neither of the two main hypotheses put forward to account for the presence of oxytocin in the ovary has proved to be entirely satisfactory.

The first hypothesis proposes a paracrine role for oxytocin in the regulation of ovarian steroidogenesis.

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M. P. EMBREY
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SUMMARY

The effects of desamino-oxytocin and oxytocin on the human pregnant uterus were compared by means of tocographic measurements. Desamino-oxytocin was found to be twice as potent as oxytocin.

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G. K. BENSON
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S. J. FOLLEY
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J. S. TINDAL
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SUMMARY

Synthetic oxytocin ('Syntocinon') and valyl oxytocin have been assayed for oxytocic and milk-ejection activities. In agreement with the previous results of others, valyl oxytocin exhibited about five times as much milk-ejection activity, per unit of oxytocic activity, as that shown by oxytocin. However, valyl oxytocin was no more active than synthetic oxytocin in retarding mammary involution in rats whose young were removed on the 4th day of lactation. This experiment, therefore, provided no evidence that the involution-retarding action of oxytocin is mediated by a direct effect on the myoepithelium of the mammary gland.

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C. Meyer
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M. J. Freund-Mercier
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Y. Guerné
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Ph. Richard
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ABSTRACT

Plasma concentrations of oxytocin and vasopressin were measured in relationship to oxytocin cell firing during suckling in urethane-anaesthetized rats.

Preliminary experiments showed that plasma concentrations of oxytocin and vasopressin, which were increased immediately after anaesthesia, reverted to basal concentrations 3 h later. Moreover, it was found that exogenous oxytocin had entirely disappeared 5 min after i.v. bolus injections of known doses of oxytocin.

Suckling did not modify the basal plasma concentration of oxytocin (14·6 ± 2·9 compared with 14·±61·5 pmol/l before suckling) except during a brief period immediately after neurosecretory bursts on oxytocin cells (37·8 ± 5·2 pmol/l; P < 0·001, n = 11). The plasma concentration of oxytocin did not differ significantly from the basal concentration 1·5 min later. The plasma concentration of vasopressin never varied.

After two neurosecretory bursts of similar amplitude (total number of spikes during the burst) recorded on the same oxytocin cell, the variations in plasma concentration of oxytocin were also similar. When, for a given cell, the amplitude of neurosecretory bursts increased or decreased, the amount of oxytocin released changed in the same way.

These data demonstrate (1) that suckling induces pulsatile release of oxytocin without vasopressin, and (2) a direct relationship between the amounts of oxytocin released and the amplitude of oxytocin cell neurosecretory bursts which argue in favour of simultaneous increases or decreases in the neurosecretory burst amplitudes on all oxytocin cells.

J. Endocr. (1987) 114, 263–270

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O. ALTHABE Jr.
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I. C. ARNT
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L. A. BRANDA
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R. CALDEYRO-BARCIA
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SUMMARY

The milk-ejecting potencies of deamino-oxytocin and oxytocin were compared by means of recordings of intramammary pressure in lactating women.

No difference in milk-ejecting potency was found between the two peptides in one woman 16 months after delivery; at this time her blood did not inactivate either of the peptides.

In other women on the third day post partum, deamino-oxytocin was found to be 1·5 times as potent as oxytocin (w/w). At this stage, the blood of the patients inactivated oxytocin (half life: 10 min.) but not deamino-oxytocin; this effect accounts only in part for the difference in potency between the two peptides.

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J. R. Seckl
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S. L. Lightman
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ABSTRACT

The release of oxytocin into the cerebrospinal fluid (CSF) and plasma of lactating goats was studied following implantation of cisternal and lateral ventricular cannulae. Hand milking was associated with a significant increase in plasma concentrations of oxytocin, but no change in plasma concentrations of vasopressin or CSF concentrations of oxytocin. Intracerebroventricular (i.c.v.) infusion of oxytocin itself (1 pmol/min for 60 min) had no effect on basal plasma levels of oxytocin. It did, however, markedly potentiate the milking-induced increase in plasma oxytocin above the levels achieved during i.c.v. infusion of artificial CSF alone. In the goat, therefore, milking results in a selective release of oxytocin into the plasma, and this release can be potentiated by the presence of increased concentrations of oxytocin in the CSF.

J. Endocr. (1988) 116, 273–277

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Meghan M White Department of Pharmacological and Physiological Science, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA

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Willis K Samson Department of Pharmacological and Physiological Science, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA

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and SON contain neurons that produce arginine vasopressin (AVP) and/or oxytocin (OT) and project not only to the posterior pituitary gland, but also elsewhere within the central nervous system (CNS). While AVP is well known to control fluid balance by

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Greisa Vila
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Michaela Riedl
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Michael Resl
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Aart Jan van der Lely Division of Endocrinology and Metabolism, Division of Endocrinology, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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Leo J Hofland Division of Endocrinology and Metabolism, Division of Endocrinology, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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Martin Clodi
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Anton Luger
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expenditure ( van der Lely et al . 2004 ). A recent study has showed that intraventricular administration of ghrelin increases the c-fos activity of oxytocin (OXT)-secreting neurons ( Olszewski et al . 2007 ). OXT is involved in social bonding, has important

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