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Cuili Wang
Cuili Wang
State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China
Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China
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Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China
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Dongteng Liu
Dongteng Liu
State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China
Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China
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Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China
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Weiting Chen
Weiting Chen
Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, Macau, China
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Wei Ge
Wei Ge
Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, Macau, China
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Wanshu Hong
Wanshu Hong
State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China
Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China
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Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China
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Yong Zhu
Yong Zhu
State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China
Department of Biology, East Carolina University, Greenville, North Carolina, USA
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Department of Biology, East Carolina University, Greenville, North Carolina, USA
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Shi X Chen
Shi X Chen
State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China
Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China
State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, Xiamen University, Xiamen, China
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Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China
State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, Xiamen University, Xiamen, China
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Introduction Gonadal steroid hormones play key roles in regulating gametogenesis, but they also exert both positive and negative feedback effects at the hypothalamic and pituitary levels. In tetrapod vertebrates, progesterone (P4) is the
Chengyuan Lin
Chengyuan Lin
School of Biological Sciences, University of Hong Kong, Hong Kong
Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong
YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, Kunming, China
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Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong
YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, Kunming, China
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Xue Jiang
Xue Jiang
School of Biological Sciences, University of Hong Kong, Hong Kong
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Mulan He
Mulan He
School of Biological Sciences, University of Hong Kong, Hong Kong
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Ling Zhao
Ling Zhao
Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong
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Tao Huang
Tao Huang
Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong
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Zhaoxiang Bian
Zhaoxiang Bian
Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong
YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, Kunming, China
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YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, Kunming, China
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Anderson O L Wong
Anderson O L Wong
School of Biological Sciences, University of Hong Kong, Hong Kong
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Introduction Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the secretin/glucagon family, is a 38-amino acid (a.a.) peptide isolated from ovine hypothalamus with stimulatory activity on cAMP production in rat pituitary
Benoit Cox
Benoit Cox
Department of Development and Regeneration, Cluster of Stem Cell and Developmental Biology, Unit of Stem Cell Research, University of Leuven (KU Leuven), Leuven, Belgium
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Heleen Roose
Heleen Roose
Department of Development and Regeneration, Cluster of Stem Cell and Developmental Biology, Unit of Stem Cell Research, University of Leuven (KU Leuven), Leuven, Belgium
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Annelies Vennekens
Annelies Vennekens
Department of Development and Regeneration, Cluster of Stem Cell and Developmental Biology, Unit of Stem Cell Research, University of Leuven (KU Leuven), Leuven, Belgium
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Hugo Vankelecom
Hugo Vankelecom
Department of Development and Regeneration, Cluster of Stem Cell and Developmental Biology, Unit of Stem Cell Research, University of Leuven (KU Leuven), Leuven, Belgium
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Pituitary stem cells: purported players in pituitary housekeeping The pituitary gland acts as the governor of the endocrine system, integrating inputs from the central hypothalamus and from peripheral grounds to adjust the output of endocrine
Erika Y Faraoni
Erika Y Faraoni
Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
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María Andrea Camilletti
María Andrea Camilletti
Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
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Alejandra Abeledo-Machado
Alejandra Abeledo-Machado
Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
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Laura D Ratner
Laura D Ratner
Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
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Fernanda De Fino
Fernanda De Fino
Instituto de Investigaciones Farmacológicas, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
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Ilpo Huhtaniemi
Ilpo Huhtaniemi
Department of Surgery & Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, London, UK
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Susana B Rulli
Susana B Rulli
Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
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Graciela Díaz-Torga
Graciela Díaz-Torga
Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
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Introduction The human chorionic gonadotrophin (hCG), secreted normally by the placenta, is a member of the family of glycoprotein hormones (with the pituitary hormones LH, FSH and TSH) that share structural similarities. They are heterodimers
P G Murray
P G Murray
Centre for Paediatrics and Child Health, Department of Paediatric Endocrinology, Department of Endocrinology, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, M13 9WL, UK
Centre for Paediatrics and Child Health, Department of Paediatric Endocrinology, Department of Endocrinology, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, M13 9WL, UK
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Centre for Paediatrics and Child Health, Department of Paediatric Endocrinology, Department of Endocrinology, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, M13 9WL, UK
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C E Higham
C E Higham
Centre for Paediatrics and Child Health, Department of Paediatric Endocrinology, Department of Endocrinology, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, M13 9WL, UK
Centre for Paediatrics and Child Health, Department of Paediatric Endocrinology, Department of Endocrinology, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, M13 9WL, UK
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Centre for Paediatrics and Child Health, Department of Paediatric Endocrinology, Department of Endocrinology, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, M13 9WL, UK
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P E Clayton
P E Clayton
Centre for Paediatrics and Child Health, Department of Paediatric Endocrinology, Department of Endocrinology, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, M13 9WL, UK
Centre for Paediatrics and Child Health, Department of Paediatric Endocrinology, Department of Endocrinology, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, M13 9WL, UK
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Centre for Paediatrics and Child Health, Department of Paediatric Endocrinology, Department of Endocrinology, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, M13 9WL, UK
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Introduction The work of Geoffrey Harris in the 1940s and 1950s identified that the function of the anterior pituitary gland was not dependent on a direct nerve supply but was controlled by neurohumoral factors in the portal blood supply. These
Eva M G Viho
Eva M G Viho
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Jan Kroon
Jan Kroon
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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Richard A Feelders
Richard A Feelders
Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands
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René Houtman
René Houtman
Precision Medicine Lab, Oss, the Netherlands
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Elisabeth S R van den Dungen
Elisabeth S R van den Dungen
Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands
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Alberto M Pereira
Alberto M Pereira
Department of Endocrinology and Metabolism, Amsterdam University Medical Center, Amsterdam, the Netherlands
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Hazel J Hunt
Hazel J Hunt
Corcept Therapeutics, Menlo Park, CA, USA
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Leo J Hofland
Leo J Hofland
Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands
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Onno C Meijer
Onno C Meijer
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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( de Kloet et al. 2005 , Joëls 2018 ). The maintenance of homeostasis by GCs is tightly regulated by hypothalamus–pituitary–adrenal (HPA) axis activity ( Lightman et al. 2020 ). The hypothalamic neurons from the paraventricular nucleus release the
Romain Fontaine
Romain Fontaine
Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway
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Eirill Ager-Wick
Eirill Ager-Wick
Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway
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Kjetil Hodne
Kjetil Hodne
Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway
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Finn-Arne Weltzien
Finn-Arne Weltzien
Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway
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Introduction The gonadotropins luteinizing hormone (Lh) and follicle-stimulating hormone (Fsh) are key players in the vertebrate brain–pituitary–gonad (BPG) axis controlling sexual maturation. Whereas the equivalent hormones in mammals and
Xiang Zhou
Xiang Zhou
Department of Pharmacology and Therapeutics, McGill University, Montreal, Québec, Canada
Centre for Research in Reproduction and Development, McGill University, Montreal, Québec, Canada
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Centre for Research in Reproduction and Development, McGill University, Montreal, Québec, Canada
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Ying Wang
Ying Wang
Department of Pharmacology and Therapeutics, McGill University, Montreal, Québec, Canada
Centre for Research in Reproduction and Development, McGill University, Montreal, Québec, Canada
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Centre for Research in Reproduction and Development, McGill University, Montreal, Québec, Canada
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Luisina Ongaro
Luisina Ongaro
Department of Pharmacology and Therapeutics, McGill University, Montreal, Québec, Canada
Centre for Research in Reproduction and Development, McGill University, Montreal, Québec, Canada
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Centre for Research in Reproduction and Development, McGill University, Montreal, Québec, Canada
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Ulrich Boehm
Ulrich Boehm
Department of Pharmacology and Toxicology, University of Saarland School of Medicine, Homburg, Germany
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Vesa Kaartinen
Vesa Kaartinen
Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA
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Yuji Mishina
Yuji Mishina
Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA
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Daniel J Bernard
Daniel J Bernard
Department of Pharmacology and Therapeutics, McGill University, Montreal, Québec, Canada
Centre for Research in Reproduction and Development, McGill University, Montreal, Québec, Canada
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Centre for Research in Reproduction and Development, McGill University, Montreal, Québec, Canada
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Introduction The pituitary glycoprotein follicle-stimulating hormone (FSH) is an essential regulator of ovarian function and testicular development in mammals. FSH synthesis by pituitary gonadotrope cells is primarily stimulated by
Alan G Watts
Alan G Watts
Department of Biological Sciences, USC Dornsife College of Letters, Arts, and Sciences, University of Southern California, Hedco Neuroscience Building, MC 2520, Los Angeles, California 90089‐2520, USA
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used for teaching anatomy at Oxford ( Vogt 1972 ). A hallmark of Harris's research was a continuous emphasis on establishing structure–function relationships between the hypothalamus and the pituitary gland. This focus played a major part in his ability
Tiffany K Miles
Tiffany K Miles
Department of Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Ana Rita Silva Moreira
Ana Rita Silva Moreira
Department of Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Melody L Allensworth-James
Melody L Allensworth-James
Department of Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Angela K Odle
Angela K Odle
Department of Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Anessa C Haney
Anessa C Haney
Department of Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Angus M MacNicol
Angus M MacNicol
Department of Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Melanie C MacNicol
Melanie C MacNicol
Department of Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Gwen V Childs
Gwen V Childs
Department of Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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). In the pituitary gland, leptin receptors are predominantly expressed in somatotropes, where leptin stimulates the synthesis of the lipolytic hormone, growth hormone (GH) ( Childs et al. 2011 ). Ghrelin serves to signal the opposite nutritional
