& Rosenfield 2003 ), including the pituitary hormone prolactin. Prolactin receptors (PRLR) have been localised to hair follicles ( Craven et al. 2001 ) and expression of mRNAs encoding one long (PRLRL) and two short forms of the receptor (PRLRS2 and PRLRS3
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A J Craven, A J Nixon, M G Ashby, C J Ormandy, K Blazek, R J Wilkins, and A J Pearson
María Andrea Camilletti, Alejandra Abeledo-Machado, Jimena Ferraris, Pablo A Pérez, Erika Y Faraoni, Daniel Pisera, Silvina Gutierrez, and Graciela Díaz-Torga
vehicle (Ethanol, 1 μM) were used as controls. After experimental treatments, medium was collected and stored at −70°C until rat prolactin radioimmunoassays (rPRL RIA) were performed. Rat prolactin radioimmunoassay (rPRL RIA) PRL levels were
F E Utama, M J LeBaron, L M Neilson, A S Sultan, A F Parlow, K-U Wagner, and H Rui
Introduction Growth and differentiation of breast cancer is regulated by hormones, notably estrogen, progesterone and prolactin. In rodents, prolactin is a well-documented tumor promoter of the mammary gland, as revealed by a variety
Michael Wallis
Introduction Prolactin is a protein hormone found in the pituitary gland of most vertebrates, which in mammals plays a central role in the regulation of mammary growth and lactation. In most mammals, prolactin is encoded by a single gene, but
Sophie Bernichtein, Philippe Touraine, and Vincent Goffin
Classical view Prolactin (PRL) was discovered 80 years ago ( Stricker & Grueter 1928 , Riddle et al . 1933 ). In Endocrinology textbooks, PRL is defined as a pituitary-secreted polypeptide hormone which was named for its stimulatory action on
Anne Q Reuwer, Marco van Eijk, Felicia M Houttuijn-Bloemendaal, Chris M van der Loos, Nike Claessen, Peter Teeling, John J P Kastelein, Jörg Hamann, Vincent Goffin, Jan H von der Thüsen, Marcel Th B Twickler, and Jan Aten
. 2009 ). Whether prolactin is involved in the pathogenesis of human atherosclerosis and its atherothrombotic complications is currently the focus of our research ( Reuwer et al . 2009 a , b ). Recent observations suggest that prolactin, either in excess
Andre P Seale, Benjamin P Moorman, Jacob J Stagg, Jason P Breves, Darren T Lerner, and E Gordon Grau
Introduction A necessary component of the systems that direct osmoregulatory processes are osmoreceptors that detect deviations from salt and water balance and initiate adaptive responses to restore equilibrium. The prolactin (Prl)-secreting cells
Ronald J van der Sluis, Tim van den Aardweg, Anne Q Reuwer, Marcel T Twickler, Florence Boutillon, Miranda Van Eck, Vincent Goffin, and Menno Hoekstra
anti-atherogenic therapies. Recent clinical evidence has identified the pituitary-derived hormone prolactin as a potential novel target to treat patients at risk of cardiovascular disease. Hyperprolactinemic subjects harboring a prolactin
K Horiguchi, S Yagi, K Ono, Y Nishiura, M Tanaka, M Ishida, and T Harigaya
Introduction The various functions of prolactin (PRL) in vertebrates include the growth and differentiation of mammary epithelium, lactation in mammals, osmoregulation and parental behavior in teleosts, amphibian development
Josephine F Trott, Katherine C Horigan, Julia M Gloviczki, Kristen M Costa, Bradley A Freking, Chantal Farmer, Kanako Hayashi, Thomas Spencer, Joseph E Morabito, and Russell C Hovey
Introduction The polypeptide hormone prolactin (PRL) regulates numerous physiological functions across multiple species. In pigs, PRL exerts its most significant effects on mammary gland growth ( Farmer et al . 2000 ), lactation ( Farmer et al
