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Riccardo Dore Department of Internal Medicine I, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany

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Luka Levata Department of Internal Medicine I, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany

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Hendrik Lehnert Department of Internal Medicine I, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany

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Carla Schulz Department of Internal Medicine I, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany

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of food ( Moreau & Ciriello 2013 ). Prolonged water deprivation increases Nucb2 mRNA and NUCB2/nesfatin-1 protein levels in the SFO as well as in the SON and PVN ( Yoshimura et al. 2014 ), which are normalized upon rehydration ( Yoshimura et al

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Mathis Grossmann Department of Medicine Austin Health, Department of Endocrinology, University of Melbourne, 145 Studley Road, Heidelberg, Victoria 3084, Australia
Department of Medicine Austin Health, Department of Endocrinology, University of Melbourne, 145 Studley Road, Heidelberg, Victoria 3084, Australia

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commencing androgen deprivation therapy, both total as well as, although not in all studies ( Smith 2004 ), visceral fat mass increases ( Hamilton et al . 2011 ) within 3 months. This is associated with increased insulin resistance, which is further

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Willis K Samson
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Gina L C Yosten
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Jaw-Kang Chang Department of Pharmacological and Physiological Science, Phoenix Pharmaceuticals Inc., Department of Physiology, Saint Louis University, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA

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Alastair V Ferguson Department of Pharmacological and Physiological Science, Phoenix Pharmaceuticals Inc., Department of Physiology, Saint Louis University, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA

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Meghan M White
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conditions and in response to water deprivation. Furthermore, the antidipsogenic effects of synthetic obestatin appear to reflect a potentially important action of the endogenous peptide to restrain water drinking since both ad libitum and dehydration

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Sarika Paul Centre for Biological Timing, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK

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Timothy M Brown Centre for Biological Timing, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK

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.11.030 ) Baumgartner A Dietzel M Saletu B Wolf R Campos-Barros A Graf KJ Kurten I Mannsmann U 1993 Influence of partial sleep deprivation on the secretion of thyrotropin, thyroid hormones, growth hormone, prolactin, luteinizing hormone, follicle

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Gary A Wittert Freemasons Centre for Male Health and Wellbeing, South Australian Health and Medical Research Institute, and University of Adelaide, Adelaide, South Australia, Australia

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Mathis Grossmann Department of Medicine, The University of Melbourne and Department of Endocrinology Austin Health, Heidelberg, Australia

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Bu B Yeap Medical School, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia

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David J Handelsman ANZAC Research Institute, University of Sydney and Andrology Department, Concord Hospital, Sydney, New South Wales, Australia

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sensitive to testosterone treatment, while both groups achieved 70% sufficient physical activity at 2 years. Further we observed no mental or physical quality of life benefits and no improvement in quality of sleep ( Wittert et al. 2021 ), findings that

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Adrián Báez-Ruiz Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México
Department of Cellular Physiology, Faculty of Science, UASLP, San Luis Potosí, México

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Natalí N Guerrero-Vargas Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México
Department of Anatomy, Faculty of Medicine, UNAM, DF, México

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Fernando Cázarez-Márquez Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México

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Elizabeth Sabath Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México

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María del Carmen Basualdo Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México

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Roberto Salgado-Delgado Department of Cellular Physiology, Faculty of Science, UASLP, San Luis Potosí, México

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Carolina Escobar Department of Anatomy, Faculty of Medicine, UNAM, DF, México

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Ruud M Buijs Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México

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at −80°C. One week before killing, all groups were 16-h food deprived such that the onset of food deprivation was 4 h before the time the animals normally received food. Blood was collected under fasting conditions for hormones and metabolites

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Esther Isorna Departamento de Fisiología (Fisiología Animal II), Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain

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Nuria de Pedro Departamento de Fisiología (Fisiología Animal II), Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain

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Ana I Valenciano Departamento de Fisiología (Fisiología Animal II), Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain

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Ángel L Alonso-Gómez Departamento de Fisiología (Fisiología Animal II), Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain

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María J Delgado Departamento de Fisiología (Fisiología Animal II), Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain

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F Jr Krueger JM 2004 Rhythms of ghrelin, leptin, and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation . American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 287

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Isis Gabrielli Barbieri de Oliveira Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Marcos Divino Ferreira Junior Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Paulo Ricardo Lopes Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Dhiogenes Balsanufo Taveira Campos Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Marcos Luiz Ferreira-Neto Departament of Physiology, Institute of Biomedical Science, Laboratory of Electrophysiology and Cardiovascular Physiology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil

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Eduardo Henrique Rosa Santos Departament of Physiology, Institute of Biomedical Science, Laboratory of Electrophysiology and Cardiovascular Physiology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil

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Paulo Cezar de Freitas Mathias Department of Biotechnology, Genetics and Cell Biology, Laboratory of Secretion Cell Biology, State University of Maringá, Maringá, Paraná, Brazil

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Flávio Andrade Francisco Department of Biotechnology, Genetics and Cell Biology, Laboratory of Secretion Cell Biology, State University of Maringá, Maringá, Paraná, Brazil

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Bruna Del Vechio Koike Medical Department, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil

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Carlos Henrique de Castro Department of Physiological Science, Integrative Laboratory of Cardiovascular and Neurological Pathophysiology, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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André Henrique Freiria-Oliveira Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Gustavo Rodrigues Pedrino Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Rodrigo Mello Gomes Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Daniel Alves Rosa Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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temperature, hormones release and sleep–wake cycles ( Coomans et al. 2015 , Kingsbury et al. 2016 ). Meanwhile, peripheral cells in the heart, liver and pancreas also contain intrinsic circadian oscillators ( Pezuk et al. 2010 , Podobed et al. 2014

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S A Cavigelli
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S L Monfort
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T K Whitney
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Y S Mechref
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M Novotny
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M K McClintock
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circadian glucocorticoid rhythm is altered in several pathological states; e.g. major depressive disorder ( Sachar et al. 1973 , Linkowski et al. 1985 , Pfohl et al. 1985 ), Alzheimer’s disease, sleep deprivation ( Spiegel et al. 1999 ), and normal

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Marta Lantero Rodriguez Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Maaike Schilperoort Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Inger Johansson Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Elin Svedlund Eriksson Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Vilborg Palsdottir Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Jan Kroon Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Marcus Henricsson Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Sander Kooijman Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Mia Ericson Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Jan Borén Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Claes Ohlsson Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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John-Olov Jansson Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Malin C Levin Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Patrick C N Rensen Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Åsa Tivesten Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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). Interestingly, both androgen withdrawal (androgen deprivation therapy of prostate cancer) in men ( Jones et al. 2012 , Gonzalez et al. 2018 ) and estrogen withdrawal (menopause) in women ( Freedman 2014 ) have been associated with the occurrence of hot

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