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Division of Diabetes, Endocrinology, & Metabolism, Vanderbilt University Medical Center School of Medicine, Nashville, Tennessee, USA
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-1298 ) Rakhshandehroo M Hooiveld G Müller M & Kersten S 2009 Comparative analysis of gene regulation by the transcription factor PPARα between mouse and human . PLoS One 4 e6796 . ( https://doi.org/10.1371/journal.pone.0006796 ) Rocha DM Faloona GR
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Garabedian MJ Myers RM 2009 Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation . Genome Research 19 2163 – 2171 . ( https://doi.org/10.1101/gr.097022.109 ) Reddy TE Gertz J Crawford GE
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-Pacheco 1996 ). Activation of the receptors results in waves of gene regulation, with both transactivation and transrepression of responsive genes ( Datson et al . 2008 ). Although the MR and GR share almost identical DNA-binding domains, they do not bind to
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). Determination of the relative binding affinity of different TFs to their various DNA-binding sites is fundamentally important for a comprehensive understanding of gene regulation. The whole profile of DNA-binding affinity of a TF protein to all possible DNA
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JR Jager J Soccio RE , et al . 2015 GENE REGULATION: Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock . Science 1488 – 1492 . ( https://doi.org/10.1126/science.aab3021 ) 26044300 Zvonic S Ptitsyn AA
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that are notoriously difficult to identify. Thus, epigenetic changes and regulation become increasingly important. The research community is increasingly aware of the role that chromatin plays in gene regulation, transcription, and disease development
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effects of V The mechanisms underlying the patterns of gene regulation observed at PND35 and PND50 after exposure to G, V, and GV during gestation and lactation remain to be explored. V is an anti-androgenic compound that can be metabolized to generate two
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. Journal of Biological Chemistry 280 6197 – 6203 . doi:10.1074/jbc.M412911200 . You J Reilly GC Zhen X Yellowley CE Chen Q Donahue HJ Jacobs CR 2001 Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium
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): cloning, preovulatory induction of gene expression, hormonal gene regulation and analysis of promoter region. Journal of Molecular Endocrinology 35 571 –583. Kazeto Y , Ijiri S, Place AR, Zohar Y & Trant JM 2001 The 5
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gene promoter (Fig. 11A ). These strong promoter activities indicated that the cloned 5′-flanking regions did represent the functional promoters of the seabream PRLR genes. Regulation of promoter activities by steroid