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Mei-Fway Iu
Mei-Fway Iu
Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
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Hiroshi Kaji
Hiroshi Kaji
Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
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Hideaki Sowa
Hideaki Sowa
Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
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Junko Naito
Junko Naito
Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
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Toshitsugu Sugimoto
Toshitsugu Sugimoto
Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
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Kazuo Chihara
Kazuo Chihara
Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
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, numerous questions remain about its mechanism. Histomorphometric studies of GIO revealed an increase in the number of osteoclasts and bone-resorbing sites as well as a reduction in bone formation ( Bressot et al. 1979 ). However, these changes in bone
Thomas Funck-Brentano
Thomas Funck-Brentano
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Karin H Nilsson
Karin H Nilsson
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Robert Brommage
Robert Brommage
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Petra Henning
Petra Henning
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Ulf H Lerner
Ulf H Lerner
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Antti Koskela
Antti Koskela
Unit of Cancer Research and Translational Medicine, MRC Oulu and Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland
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Juha Tuukkanen
Juha Tuukkanen
Unit of Cancer Research and Translational Medicine, MRC Oulu and Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland
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Martine Cohen-Solal
Martine Cohen-Solal
BIOSCAR UMRS 1132, Université Paris Diderot, Sorbonne Paris Cité, INSERM, Paris, France
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Sofia Movérare-Skrtic
Sofia Movérare-Skrtic
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Claes Ohlsson
Claes Ohlsson
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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, Immunodiagostic Systems) were analyzed as a marker of bone formation. Primary bone cell cultures Primary murine osteoblasts and osteoclasts were cultured in complete α-MEM medium (MEM alpha medium (Gibco) supplemented with 10% heat-inactivated FBS (Merck
Norihiko Kato
Norihiko Kato
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Keiichiro Kitahara
Keiichiro Kitahara
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Susan R Rittling
Susan R Rittling
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Kazuhisa Nakashima
Kazuhisa Nakashima
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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David T Denhardt
David T Denhardt
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Hisashi Kurosawa
Hisashi Kurosawa
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Yoichi Ezura
Yoichi Ezura
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Masaki Noda
Masaki Noda
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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only resorption inhibitors, which so far reduce the fracture risk only by 50%, but also stimulators for bone formation especially in patients who already have lost a significant amount of bone mass ( Rosen & Bilezikian 2001 ). Parathyroid hormone (PTH
Zuzana Saidak
Zuzana Saidak
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
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UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
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Carole Le Henaff
Carole Le Henaff
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
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UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
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Sofia Azzi
Sofia Azzi
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
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UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
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Caroline Marty
Caroline Marty
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
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UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
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Pierre J Marie
Pierre J Marie
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
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UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
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Introduction Bone loss associated with ageing is characterised by decreased bone formation relative to bone resorption, resulting in altered bone microarchitecture, osteoporosis and increased risk of fractures ( Khosla et al . 2011 ). The age
Hong Liu
Hong Liu
Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College
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Jian Guo
Jian Guo
Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College
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Lin Wang
Lin Wang
Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College
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Ning Chen
Ning Chen
Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College
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Andrew Karaplis
Andrew Karaplis
Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College
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David Goltzman
David Goltzman
Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College
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Dengshun Miao
Dengshun Miao
Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College
Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College
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Institute of Dental Research, The Research Center for Bone and Stem Cells, Department of Medicine, Stomatological College
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occurring in the 1α(OH)ase −/− mice on the normal diet was responsible for the increased bone formation. Moreover, the bone volume of the normocalcemic 1α(OH)ase −/− mice on the rescue diet was less than that observed in the wild-type mice, suggesting that
Wang Xiao
Wang Xiao
Departments of Orthopaedics, Gynaecology, Department of Orthopaedic Research Institution, Department of Medicine, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China
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Fei Beibei
Fei Beibei
Departments of Orthopaedics, Gynaecology, Department of Orthopaedic Research Institution, Department of Medicine, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China
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Shen Guangsi
Shen Guangsi
Departments of Orthopaedics, Gynaecology, Department of Orthopaedic Research Institution, Department of Medicine, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China
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Jiang Yu
Jiang Yu
Departments of Orthopaedics, Gynaecology, Department of Orthopaedic Research Institution, Department of Medicine, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China
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Zhang Wen
Zhang Wen
Departments of Orthopaedics, Gynaecology, Department of Orthopaedic Research Institution, Department of Medicine, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China
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Huang Xi
Huang Xi
Departments of Orthopaedics, Gynaecology, Department of Orthopaedic Research Institution, Department of Medicine, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China
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Xu Youjia
Xu Youjia
Departments of Orthopaedics, Gynaecology, Department of Orthopaedic Research Institution, Department of Medicine, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China
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( Ross 1996 , Ray et al . 1997 ). Estrogen deficiency is regarded as the main causative factor in PMO. Withdrawal of estrogen or estrogen deficiency stimulates bone resorption by 90%, while increasing bone formation by 45%, as measured using biochemical
Russell T Turner
Russell T Turner
Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences
Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences
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Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences
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Kenneth A Philbrick
Kenneth A Philbrick
Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences
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Carmen P Wong
Carmen P Wong
Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences
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Dawn A Olson
Dawn A Olson
Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences
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Adam J Branscum
Adam J Branscum
Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences
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Urszula T Iwaniec
Urszula T Iwaniec
Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences
Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences
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Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences
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-deficient mice and leptin-receptor-deficient mice and rats have reduced overall bone mass, reduced longitudinal bone growth ( Steppan et al . 2000 , Kishida et al . 2005 ), and decreased bone formation ( Gat-Yablonski & Phillip 2008 ). In addition, impaired
Jonathan H Gooi
Jonathan H Gooi
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Ling Yeong Chia
Ling Yeong Chia
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Nicole C Walsh
Nicole C Walsh
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Morten A Karsdal
Morten A Karsdal
St Vincent's Institute, Nordic Bioscience Inc., and Department of Medicine, at St Vincent's Hospital, The University of Melbourne, 9 Princes Street, Fitzroy, Victoria 3065, Australia
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Julian M W Quinn
Julian M W Quinn
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T John Martin
T John Martin
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Natalie A Sims
Natalie A Sims
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. 2010 ). In addition to any coupling-mediated actions, we found that sCT treatment also increased the expression of sclerostin ( Gooi et al . 2010 ), an inhibitor of bone formation that is secreted by osteocytes. This stimulation of sclerostin by sCT is
Eugenie Macfarlane
Eugenie Macfarlane
Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia
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Hong Zhou
Hong Zhou
Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia
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Markus J Seibel
Markus J Seibel
Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia
Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia
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Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia
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. (2010) disrupted the GR specifically in the skeletal primordium cells using a Runx2-Cre promoter (Runx2-Cre; GR flox/flox ). These GR Runx2 mice displayed efficient recombination at all sites of endochondral and intramembranous bone formation
Vikte Lionikaite
Vikte Lionikaite
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Karin L Gustafsson
Karin L Gustafsson
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Anna Westerlund
Anna Westerlund
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Sara H Windahl
Sara H Windahl
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Antti Koskela
Antti Koskela
Department of Anatomy and Cell Biology, Medical Research Center, University of Oulu, Oulu, Finland
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Juha Tuukkanen
Juha Tuukkanen
Department of Anatomy and Cell Biology, Medical Research Center, University of Oulu, Oulu, Finland
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Helena Johansson
Helena Johansson
Institute for Health and Aging, Catholic University of Australia, Melbourne, Australia
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Claes Ohlsson
Claes Ohlsson
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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H Herschel Conaway
H Herschel Conaway
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Petra Henning
Petra Henning
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Ulf H Lerner
Ulf H Lerner
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute for Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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et al. 2016 ), very few studies have analyzed effects of vitamin A on bone formation in vivo . Kneissel et al. and Lind et al. found that hypervitaminosis A decreased mineralizing surfaces on the periosteal side of cortical bone in the femur and
