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H J Novaira, D S Ornellas, T M Ortiga-Carvalho, X M Zhang, J Souza-Menezes, S E Guggino, W B Guggino, and M M Morales

Journal of Physiology Gastrointestinal and Liver Physiology 276 G491 –G498. Grubb BR & Boucher RC 1999 Pathophysiology of gene-targeted mouse models for cystic fibrosis. Physiology Reviews 79 S193 –S214

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Xiwen Xiong, Cuicui Zhang, Yang Zhang, Rui Fan, Xinlai Qian, and X Charlie Dong

Biochemical Sciences 39 72 – 81 . ( doi:10.1016/j.tibs.2013.12.002 ) Lee KY Russell SJ Ussar S Boucher J Vernochet C Mori MA Smyth G Rourk M Cederquist C Rosen ED 2013 Lessons on conditional gene targeting in

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C Suárez, J Vela, I García-Tornadú, and D Becu-Villalobos

, Stapleton G, Lorraine D, Dott K, Martin C, Wang L, Hedlund E, Seckl JR, Gustafsson J-A & Lathe R 2001 Neurosteroid hydroxylase CYP7B. Vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and

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Amanda E Brandon, Ella Stuart, Simon J Leslie, Kyle L Hoehn, David E James, Edward W Kraegen, Nigel Turner, and Gregory J Cooney

related to differences in many factors, including variations in gene-targeting strategies ( Hoehn et al . 2012 ). That is, Acc2 −/− mice generated by Wakil and colleagues targeted a different exon to other groups and their mice are also engineered to

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Siân E Piret and Rajesh V Thakker

that are similar to those in man. In addition, the coding regions of mouse and human genomes share ∼85% identity ( Waterston et al . 2002 ) and development of gene targeting methods in the mouse has facilitated the generation of mouse models for human

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A Santillo, L Burrone, S Falvo, R Senese, A Lanni, and G Chieffi Baccari

reaction contained 12.5 μl iQSYBR green Supermix (code 170-8882, Bio-Rad Laboratories), 2 μl cDNA template and 6 nmol/l primers. The expression of individual gene targets was analysed using the MyiQ2 Real-time PCR machine (Bio-Rad Laboratories). The

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Zhenguang Zhang, Agnes E Coutinho, Tak Yung Man, Tiina M J Kipari, Patrick W F Hadoke, Donald M Salter, Jonathan R Seckl, and Karen E Chapman

.1161/ATVBAHA.111.241364 22207732 Clausen BE Burkhardt C Reith W Renkawitz R Forster I 1999 Conditional gene targeting in macrophages and granulocytes using LysMcre mice . Transgenic Research 8 265 – 277 . ( doi:10.1023/A

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V Rider, T Potapova, G Dai, and M J Soares

( Lundberg & Weinberg 1998 ). There are two E-type cyclins that share 75% amino acid sequence similarity within the cyclin box and are normally co-expressed in proliferating cells ( Geng et al. 2001 ). Mice lacking both cyclin E1 and cyclin E2 by gene

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Johan Svensson, Jon Kindblom, Ruijin Shao, Sofia Movérare-Skrtic, Marie K Lagerquist, Niklas Andersson, Klara Sjögren, Katrien Venken, Dirk Vanderschueren, John-Olov Jansson, Olle Isaksson, and Claes Ohlsson

Inducible gene targeting in mice . Science 269 1427 – 1429 . Lam J Leppert J Vemulapalli S Shvarts O Belldegrun A 2006 Secondary hormonal therapy for advanced prostate cancer . Journal of Urology 175 27 – 34 . Liu J Grinberg A

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J M P Pabona, M C Velarde, Z Zeng, F A Simmen, and R C M Simmen

binding protein by gene targeting technology . Molecular and Cellular Biology 23 2489 – 2500 . Mussi P Liao L Park S-E Ciana P Maggi A Katzenellenbogen BS Xu J O'Malley BW 2006 Haploinsufficiency of the corepressor of estrogen