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A Edlund
A Edlund
Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
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M Barghouth
M Barghouth
Unit of Islet Pathophysiology, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
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M Hühn
M Hühn
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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M Abels
M Abels
Unit of Neuroendocrine Cell biology, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
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J S E Esguerra
J S E Esguerra
Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
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I G Mollet
I G Mollet
Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
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E Svedin
E Svedin
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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A Wendt
A Wendt
Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
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E Renström
E Renström
Unit of Islet Pathophysiology, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
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E Zhang
E Zhang
Unit of Islet Pathophysiology, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
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N Wierup
N Wierup
Unit of Neuroendocrine Cell biology, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
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B J Scholte
B J Scholte
Department of Cell Biology, Erasmus MC, Rotterdam, the Netherlands
Pediatric Pulmonology, Erasmus MC, Rotterdam, the Netherlands
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Pediatric Pulmonology, Erasmus MC, Rotterdam, the Netherlands
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M Flodström-Tullberg
M Flodström-Tullberg
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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L Eliasson
L Eliasson
Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
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F508del beta cells have defective exocytosis and insulin secretion. Finally, we measured islet glucagon and somatostatin secretion. The data presented highlight the important contribution of CFTR in beta cells for functional insulin secretion
Glyn M Noguchi
Glyn M Noguchi
Department of Neurobiology, Physiology & Behavior, University of California Davis, Davis, California, USA
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Vincent C Castillo
Vincent C Castillo
Department of Neurobiology, Physiology & Behavior, University of California Davis, Davis, California, USA
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Cynthia J Donaldson
Cynthia J Donaldson
Salk Institute for Biological Studies, La Jolla, California, USA
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Marcus R Flisher
Marcus R Flisher
Department of Neurobiology, Physiology & Behavior, University of California Davis, Davis, California, USA
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Ariana T Momen
Ariana T Momen
Department of Neurobiology, Physiology & Behavior, University of California Davis, Davis, California, USA
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Alan Saghatelian
Alan Saghatelian
Salk Institute for Biological Studies, La Jolla, California, USA
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Mark O Huising
Mark O Huising
Department of Neurobiology, Physiology & Behavior, University of California Davis, Davis, California, USA
Department of Physiology & Membrane Biology, University of California Davis, Davis, California, USA
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Department of Physiology & Membrane Biology, University of California Davis, Davis, California, USA
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Introduction The alpha cells of the pancreatic islets of Langerhans are important physiological regulators of blood glucose that act to raise blood glucose levels via the actions of their principal hormone, glucagon. Despite being
Elliott P Brooks
Elliott P Brooks
Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA
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Lori Sussel
Lori Sussel
Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA
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Introduction α cells are one of four major endocrine cell types that reside in adult pancreatic endocrine clusters called the Islets of Langerhans. The islet α cells secrete the hormone glucagon in response to hypoglycemic conditions to
Sarah L Armour
Sarah L Armour
Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Denmark
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Jade E Stanley
Jade E Stanley
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
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James Cantley
James Cantley
Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, UK
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E Danielle Dean
E Danielle Dean
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Division of Diabetes, Endocrinology, & Metabolism, Vanderbilt University Medical Center School of Medicine, Nashville, Tennessee, USA
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Division of Diabetes, Endocrinology, & Metabolism, Vanderbilt University Medical Center School of Medicine, Nashville, Tennessee, USA
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Jakob G Knudsen
Jakob G Knudsen
Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Denmark
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Introduction Glucagon is secreted from alpha cells located in pancreatic islets of Langerhans and is an important counter-regulatory hormone to insulin, acting to increase blood glucose. Indeed, it was this physiological hyperglycaemic effect
Paul Millar
Paul Millar
SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK
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Nupur Pathak
Nupur Pathak
SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK
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Vadivel Parthsarathy
Vadivel Parthsarathy
SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK
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Anthony J Bjourson
Anthony J Bjourson
Northern Ireland Centre for Stratified Medicine, University of Ulster, C-TRIC Building, Altnagelvin Hospital, Northern Ireland, UK
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Maurice O’Kane
Maurice O’Kane
Northern Ireland Centre for Stratified Medicine, University of Ulster, C-TRIC Building, Altnagelvin Hospital, Northern Ireland, UK
Clinical Chemistry Laboratory, Western Health and Social Care Trust, Altnagelvin Hospital, Northern Ireland, UK
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Clinical Chemistry Laboratory, Western Health and Social Care Trust, Altnagelvin Hospital, Northern Ireland, UK
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Varun Pathak
Varun Pathak
SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK
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R Charlotte Moffett
R Charlotte Moffett
SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK
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Peter R Flatt
Peter R Flatt
SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK
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Victor A Gault
Victor A Gault
SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK
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surge in the number of new drug classes such as glucagon-like peptide-1 (GLP-1) agonists, dipeptidylpeptidase-4 (DPP4) inhibitors and sodium glucose cotransporter-2 (SGLT2) inhibitors ( Bailey et al . 2016 ). Although these agents may be used as
Rebecca McGirr
Rebecca McGirr
Metabolism and Diabetes and Imaging Programs, Departments of Medical Biophysics, Pathology, Medicine, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, Canada N6A 4V2
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Leonardo Guizzetti
Leonardo Guizzetti
Metabolism and Diabetes and Imaging Programs, Departments of Medical Biophysics, Pathology, Medicine, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, Canada N6A 4V2
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Savita Dhanvantari
Savita Dhanvantari
Metabolism and Diabetes and Imaging Programs, Departments of Medical Biophysics, Pathology, Medicine, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, Canada N6A 4V2
Metabolism and Diabetes and Imaging Programs, Departments of Medical Biophysics, Pathology, Medicine, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, Canada N6A 4V2
Metabolism and Diabetes and Imaging Programs, Departments of Medical Biophysics, Pathology, Medicine, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, Canada N6A 4V2
Metabolism and Diabetes and Imaging Programs, Departments of Medical Biophysics, Pathology, Medicine, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, Canada N6A 4V2
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Metabolism and Diabetes and Imaging Programs, Departments of Medical Biophysics, Pathology, Medicine, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, Canada N6A 4V2
Metabolism and Diabetes and Imaging Programs, Departments of Medical Biophysics, Pathology, Medicine, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, Canada N6A 4V2
Metabolism and Diabetes and Imaging Programs, Departments of Medical Biophysics, Pathology, Medicine, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, Canada N6A 4V2
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Introduction Proglucagon is a prohormone that is expressed in the alpha cells of the pancreas, the L cells of the intestine and in select neurons of the brainstem. In the pancreatic alpha cell, PC2 cleaves proglucagon to yield glucagon ( Rouille et
Maaike M Roefs
Maaike M Roefs
Department of Internal Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands
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Françoise Carlotti
Françoise Carlotti
Department of Internal Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands
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Katherine Jones
Katherine Jones
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Oxford, UK
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Hannah Wills
Hannah Wills
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Oxford, UK
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Alexander Hamilton
Alexander Hamilton
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Oxford, UK
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Michael Verschoor
Michael Verschoor
Department of Internal Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands
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Joanna M Williams Durkin
Joanna M Williams Durkin
Department of Internal Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands
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Laura Garcia-Perez
Laura Garcia-Perez
Department of Internal Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands
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Melissa F Brereton
Melissa F Brereton
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
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Laura McCulloch
Laura McCulloch
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Oxford, UK
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Marten A Engelse
Marten A Engelse
Department of Internal Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands
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Paul R V Johnson
Paul R V Johnson
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Oxford, UK
Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Oxford, UK
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Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Oxford, UK
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Barbara C Hansen
Barbara C Hansen
Departments of Internal Medicine and Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA
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Kevin Docherty
Kevin Docherty
Medical Sciences, University of Aberdeen, Aberdeen, UK
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Eelco J P de Koning
Eelco J P de Koning
Department of Internal Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands
Hubrecht Institute, Utrecht, the Netherlands
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Hubrecht Institute, Utrecht, the Netherlands
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Anne Clark
Anne Clark
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Oxford, UK
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not identical methodologies. Tissue sections were rehydrated, and antigen retrieval was performed by heating slides in 0.01 M citrate buffer (pH = 6.0). Primary antibodies against insulin, glucagon, vimentin, Nkx6.1, Pdx1, N-cadherin, smooth muscle
Affiong Ika Oqua
Affiong Ika Oqua
Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
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Yusman Manchanda
Yusman Manchanda
Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
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Emma Rose McGlone
Emma Rose McGlone
Department of Surgery and Cancer, Imperial College London, London, UK
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Ben Jones
Ben Jones
Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
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Sarah Rouse
Sarah Rouse
Department of Life Sciences, Imperial College, London, UK
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Alejandra Tomas
Alejandra Tomas
Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
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, characterised by Creutzfeldt in 1979, are peptide hormones secreted in the gastrointestinal tract in response to nutrients that potentiate the glucose-dependent secretion of insulin. The primary incretins include glucagon-like peptide 1 (GLP-1), secreted mainly
Maureen J Charron
Maureen J Charron
Departments of Biochemistry, Obstetrics and Gynecology and Women's Health, Medicine, Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, F312, Bronx, New York 10461, USA
Departments of Biochemistry, Obstetrics and Gynecology and Women's Health, Medicine, Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, F312, Bronx, New York 10461, USA
Departments of Biochemistry, Obstetrics and Gynecology and Women's Health, Medicine, Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, F312, Bronx, New York 10461, USA
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Departments of Biochemistry, Obstetrics and Gynecology and Women's Health, Medicine, Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, F312, Bronx, New York 10461, USA
Departments of Biochemistry, Obstetrics and Gynecology and Women's Health, Medicine, Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, F312, Bronx, New York 10461, USA
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Patricia M Vuguin
Patricia M Vuguin
Departments of Biochemistry, Obstetrics and Gynecology and Women's Health, Medicine, Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, F312, Bronx, New York 10461, USA
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Introduction Glucagon is a 29-amino acid polypeptide secreted by the α or glucagon cell of the islet of Langerhans in response to hypoglycemia, arginine, gastric inhibitory polypeptide (during ambient reduced glucose levels), gastrin, and potassium
Thomas H Claus
Thomas H Claus
Bayer HealthCare, Pharmaceuticals, Department of Metabolic Disease Research, 400 Morgan Lane, West Haven, Connecticut 06516 USA
Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Clark Q Pan
Clark Q Pan
Bayer HealthCare, Pharmaceuticals, Department of Metabolic Disease Research, 400 Morgan Lane, West Haven, Connecticut 06516 USA
Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Joanne M Buxton
Joanne M Buxton
Bayer HealthCare, Pharmaceuticals, Department of Metabolic Disease Research, 400 Morgan Lane, West Haven, Connecticut 06516 USA
Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Ling Yang
Ling Yang
Bayer HealthCare, Pharmaceuticals, Department of Metabolic Disease Research, 400 Morgan Lane, West Haven, Connecticut 06516 USA
Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Jennifer C Reynolds
Jennifer C Reynolds
Bayer HealthCare, Pharmaceuticals, Department of Metabolic Disease Research, 400 Morgan Lane, West Haven, Connecticut 06516 USA
Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Nicole Barucci
Nicole Barucci
Bayer HealthCare, Pharmaceuticals, Department of Metabolic Disease Research, 400 Morgan Lane, West Haven, Connecticut 06516 USA
Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Michael Burns
Michael Burns
Bayer HealthCare, Pharmaceuticals, Department of Metabolic Disease Research, 400 Morgan Lane, West Haven, Connecticut 06516 USA
Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Astrid A Ortiz
Astrid A Ortiz
Bayer HealthCare, Pharmaceuticals, Department of Metabolic Disease Research, 400 Morgan Lane, West Haven, Connecticut 06516 USA
Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Steve Roczniak
Steve Roczniak
Bayer HealthCare, Pharmaceuticals, Department of Metabolic Disease Research, 400 Morgan Lane, West Haven, Connecticut 06516 USA
Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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James N Livingston
James N Livingston
Bayer HealthCare, Pharmaceuticals, Department of Metabolic Disease Research, 400 Morgan Lane, West Haven, Connecticut 06516 USA
Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Kevin B Clairmont
Kevin B Clairmont
Bayer HealthCare, Pharmaceuticals, Department of Metabolic Disease Research, 400 Morgan Lane, West Haven, Connecticut 06516 USA
Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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James P Whelan
James P Whelan
Bayer HealthCare, Pharmaceuticals, Department of Metabolic Disease Research, 400 Morgan Lane, West Haven, Connecticut 06516 USA
Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Introduction Glucagon-like peptide-1 (GLP-1) is a potent endogenous modulator of insulin secretion that is released by the L-cells in the crypts of the jejunum and ileum in response to a meal ( Kieffer & Habener 1999 ). Its function
