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Lucia Zhang
Lucia Zhang
Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
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Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
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Kathy K Lee
Kathy K Lee
Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
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Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
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Kim S Sugamori
Kim S Sugamori
Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
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Marc D Grynpas
Marc D Grynpas
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
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Jane Mitchell
Jane Mitchell
Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
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and Rat/Mouse PINP ELISA kits, respectively (Immunodiagnostic Systems, Inter Medico, Markham, ON, Canada). Bone histomorphometry Right tibiae were fixed in 10% formalin prior to decalcification with 0.5 M EDTA pH 7.4 at 4°C and subsequent
M J Devlin
M J Devlin
Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
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Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
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C Grasemann
C Grasemann
Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
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Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
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A M Cloutier
A M Cloutier
Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
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L Louis
L Louis
Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
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C Alm
C Alm
Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
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M R Palmert
M R Palmert
Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
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M L Bouxsein
M L Bouxsein
Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
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Beth Israel Deaconess Medical Center, Harvard Medical School, Hospital for Sick Children, The University of Toronto, Kinderklinik UK‐Essen, The University of Duisburg‐Essen, Department of Anthropology, University of Michigan, Boston, Massachusetts, USA
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(Immunodiagnostic Systems, Scottsdale, AZ, USA). Histology and quantitative histomorphometry Qualitative histological analysis and quantitative static and dynamic histomorphometry were performed as described previously ( Gazzerro et al . 2005 ). To examine bone
Chalida Nakalekha
Chalida Nakalekha
Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
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Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
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Chieko Yokoyama
Chieko Yokoyama
Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
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Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
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Hiroyuki Miura
Hiroyuki Miura
Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
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Neil Alles
Neil Alles
Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
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Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
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Kazuhiro Aoki
Kazuhiro Aoki
Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
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Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
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Keiichi Ohya
Keiichi Ohya
Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
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Ikuo Morita
Ikuo Morita
Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
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Departments of, Cellular Physiological Chemistry, Fixed Prosthodontics, International Research Center for Molecular Science in Tooth and Bone Diseases (Global COE program), Institute of Cellular and System Medicine, Department of Hard Tissue Engineering (Pharmacology), Graduate School
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/BS, %) were also increased in PGIS −/− animals (E and F). Values are mean± s.d. , n =5, * P <0.05, ** P <0.01. Figure 5 Adult PGIS −/− mice have increased bone turnover activity. Dynamic histomorphometry of trabecular bone in undecalcified sections of the
Richard C Lindsey
Richard C Lindsey
Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, California, USA
Center for Health Disparities and Molecular Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA
Division of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA
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Center for Health Disparities and Molecular Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA
Division of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA
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Catrina Godwin
Catrina Godwin
Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, California, USA
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Subburaman Mohan
Subburaman Mohan
Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, California, USA
Center for Health Disparities and Molecular Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA
Division of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA
Department of Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA
Department of Orthopedics, School of Medicine, Loma Linda University, Loma Linda, California, USA
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Center for Health Disparities and Molecular Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA
Division of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA
Department of Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA
Department of Orthopedics, School of Medicine, Loma Linda University, Loma Linda, California, USA
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2% osmium tetroxide and 5% potassium dichromate for 60 h. After washing, the stained bones were imaged using microCT with energy of 55 kVp, an integration time of 500 ms and a maximum isometric voxel size of 10 μm. Dynamic histomorphometry
Kristin M Aasarød
Kristin M Aasarød
Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway
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Masoud Ramezanzadehkoldeh
Masoud Ramezanzadehkoldeh
Department of Structural Engineering, NTNU, Trondheim, Norway
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Maziar Shabestari
Maziar Shabestari
Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway
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Mats P Mosti
Mats P Mosti
Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway
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Astrid K Stunes
Astrid K Stunes
Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway
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Janne E Reseland
Janne E Reseland
Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway
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Vidar Beisvag
Vidar Beisvag
Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway
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Erik Fink Eriksen
Erik Fink Eriksen
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
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Arne K Sandvik
Arne K Sandvik
Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway
Department of Gastroenterology and Hepatology, St. Olav’s Hospital, Trondheim, Norway
Centre of Molecular Inflammation Research, NTNU, Trondheim, Norway
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Department of Gastroenterology and Hepatology, St. Olav’s Hospital, Trondheim, Norway
Centre of Molecular Inflammation Research, NTNU, Trondheim, Norway
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Reinhold G Erben
Reinhold G Erben
Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Vienna, Austria
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Christiane Schüler
Christiane Schüler
Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Vienna, Austria
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Malcolm Boyce
Malcolm Boyce
Hammersmith Medicines Research, London, UK
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Bjørn H Skallerud
Bjørn H Skallerud
Department of Structural Engineering, NTNU, Trondheim, Norway
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Unni Syversen
Unni Syversen
Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway
Department of Endocrinology, St. Olav’s Hospital, Trondheim, Norway
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Department of Endocrinology, St. Olav’s Hospital, Trondheim, Norway
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Reidar Fossmark
Reidar Fossmark
Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway
Department of Gastroenterology and Hepatology, St. Olav’s Hospital, Trondheim, Norway
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Department of Gastroenterology and Hepatology, St. Olav’s Hospital, Trondheim, Norway
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slices, starting 500 slices from the growth plate. The analyses were performed with the Skyscan program CTAn (version 1.13.4.0). Cancellous bone dynamic histomorphometry The left tibiae were dissected, defleshed and fixed in 70% ethanol before
Claes Ohlsson
Claes Ohlsson
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
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Petra Henning
Petra Henning
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
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Karin H Nilsson
Karin H Nilsson
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
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Jianyao Wu
Jianyao Wu
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
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Karin L Gustafsson
Karin L Gustafsson
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
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Klara Sjögren
Klara Sjögren
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
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Anna Törnqvist
Anna Törnqvist
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
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Antti Koskela
Antti Koskela
Department of Anatomy and Cell Biology, Institute of Cancer Research and Translational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland
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Fu-Ping Zhang
Fu-Ping Zhang
Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland
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Marie K Lagerquist
Marie K Lagerquist
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
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Matti Poutanen
Matti Poutanen
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland
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Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland
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Juha Tuukkanen
Juha Tuukkanen
Department of Anatomy and Cell Biology, Institute of Cancer Research and Translational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland
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Ulf H Lerner
Ulf H Lerner
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
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Sofia Movérare-Skrtic
Sofia Movérare-Skrtic
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
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the lower end of the pedicles, and extending a further longitudinal distance of 328 µm in the caudal direction. Static and dynamic bone histomorphometry Femurs of the 51-week-old female mice were analyzed by PharmaTest Services, Ltd. as
M J Devlin
M J Devlin
Department of Anthropology, University of Michigan, Ann Arbor, Michigan, USA
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D J Brooks
D J Brooks
Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
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C Conlon
C Conlon
Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
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M van Vliet
M van Vliet
Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
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L Louis
L Louis
Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
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C J Rosen
C J Rosen
Maine Medical Center Research Institute, Scarborough, Maine, USA
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M L Bouxsein
M L Bouxsein
Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Harvard Medical School, Boston, Massachusetts, USA
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Harvard Medical School, Boston, Massachusetts, USA
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( Bouxsein et al . 2010 ). Histology and quantitative histomorphometry To examine bone formation rates, calcein (15mg/kg) was injected intraperitoneally at 9 and 2 days before killing the animals. Undecalcified bones were dehydrated and cleared on a
Norihiko Kato
Norihiko Kato
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Keiichiro Kitahara
Keiichiro Kitahara
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Susan R Rittling
Susan R Rittling
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Kazuhisa Nakashima
Kazuhisa Nakashima
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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David T Denhardt
David T Denhardt
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Hisashi Kurosawa
Hisashi Kurosawa
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Yoichi Ezura
Yoichi Ezura
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Masaki Noda
Masaki Noda
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3-10 Kanda-Surugadai 2-Chome, Chiyoda-ku Tokyo, Tokyo, Japan
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts, USA
Department of Cell Biology and Neuroscience, Rutgers University, Rutgers, New Jersey, USA
Department of Orthopedics, School of Medicine, Juntendo University, Tokyo, Japan
21st Century Center of Excellence (COE) Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo, Japan
JSPS Core to Core Program, Japan
Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Tokyo, Japan
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area (0.7×0.8 mm) of the vertebral bodies. The image data were subsequently quantified using Luzex-F automated image analysis system (Nireco, Tokyo, Japan). Histomorphometry Histomorphometric studies were conducted as
Victoria E DeMambro
Victoria E DeMambro
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Masanobu Kawai
Masanobu Kawai
The Jackson Laboratory, Medical Center Research Institute, John Hopkins University, Massachusetts General Hospital, Department of Research, 600 Main Street, Bar Harbor, Maine 04609, USA
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Thomas L Clemens
Thomas L Clemens
The Jackson Laboratory, Medical Center Research Institute, John Hopkins University, Massachusetts General Hospital, Department of Research, 600 Main Street, Bar Harbor, Maine 04609, USA
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Keertik Fulzele
Keertik Fulzele
The Jackson Laboratory, Medical Center Research Institute, John Hopkins University, Massachusetts General Hospital, Department of Research, 600 Main Street, Bar Harbor, Maine 04609, USA
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Jane A Maynard
Jane A Maynard
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Caralina Marín de Evsikova
Caralina Marín de Evsikova
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Kenneth R Johnson
Kenneth R Johnson
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Ernesto Canalis
Ernesto Canalis
The Jackson Laboratory, Medical Center Research Institute, John Hopkins University, Massachusetts General Hospital, Department of Research, 600 Main Street, Bar Harbor, Maine 04609, USA
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Wesley G Beamer
Wesley G Beamer
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Clifford J Rosen
Clifford J Rosen
The Jackson Laboratory, Medical Center Research Institute, John Hopkins University, Massachusetts General Hospital, Department of Research, 600 Main Street, Bar Harbor, Maine 04609, USA
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Leah Rae Donahue
Leah Rae Donahue
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the distal femur. In addition, cortical thickness data were obtained at the mid-shaft. The MicroCT40 unit was calibrated weekly, and femurs were scanned under conditions described previously ( DeMambro et al . 2008 ). Bone histomorphometry To
Idris Mohamed
Idris Mohamed
Metabolism Laboratory, Winthrop-University Hospital, Mineola, New York 11501, USA
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James K Yeh
James K Yeh
Metabolism Laboratory, Winthrop-University Hospital, Mineola, New York 11501, USA
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static histomorphometry of trabecular bone in the proximal tibial metaphysis and cortical bone of the cross-section at proximal to the tibia–fibular junction was shown in Table 3 . In comparison with BASAL and AMC groups, the trabecular BV (%) and
