storage in healthy WFA. Extracellular Ca 2+ influx is implicated in the processes of fat storage ( Arruda & Hotamisligil 2015 ): lipolysis ( Schimmel 1978 , Izawa et al. 1983 , Allen & Beck 1986 ) and lipogenesis ( Avasthy et al. 1988 ). Indeed
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Olena A Fedorenko, Pawitra Pulbutr, Elin Banke, Nneoma E Akaniro-Ejim, Donna C Bentley, Charlotta S Olofsson, Sue Chan, and Paul A Smith
Sung-Soo Park, Yeon-Joo Lee, Sooyeon Song, Boyong Kim, Hyuno Kang, Sejong Oh, and Eungseok Kim
unexplored. The liver plays a key role in whole-body energy homeostasis by regulating lipogenesis and fatty acid oxidation ( Reddy & Rao 2006 ). A large body of evidence has shown that two transcription factors, sterol regulatory element-binding protein 1c
Tomoaki Hayakawa, Tomomi Minemura, Toshiharu Onodera, Jihoon Shin, Yosuke Okuno, Atsunori Fukuhara, Michio Otsuki, and Iichiro Shimomura
on liver mRNA and TG content Finally, we analyzed liver mRNA levels on lipogenesis ( Fig. 7A ). The levels of lipogenic genes were not significantly different between the two groups, whereas liver TG content tended to be lower in the AdipoMR-KO mice
Caroline E Geisler and Benjamin J Renquist
hepatic de novo lipogenesis (DNL), (3) decreased hepatic beta-oxidation and ketogenesis, or (4) decreased export of lipids from the liver in very low density lipoproteins (VLDL). Hepatic lipids as signaling molecules Hepatic fatty acids act as
Flávia Maria Silva-Veiga, Carolline Santos Miranda, Fabiane Ferreira Martins, Julio Beltrame Daleprane, Carlos Alberto Mandarim-de-Lacerda, and Vanessa Souza-Mello
vs HFRU; and +60% for HFRUC vs HFRU, Fig. 7D ) in comparison with their counterparts. Treatments reduced hepatic lipogenesis and countered inflammation Lipogenesis increased in the HFRU group, which showed higher Pparγ (+228%, Fig. 8A
Samira Fargali, Thomas Scherer, Andrew C Shin, Masato Sadahiro, Christoph Buettner, and Stephen R Salton
underlying decreased adiposity in Vgf knockout mice. Expression of proteins involved in glucose uptake or lipogenesis was unchanged: GLUT4, the main transporter involved in glucose uptake into WAT, fatty acid synthase (FAS), and additional enzymes important
Isao Tamura, Hiroshi Tamura, Mai Kawamoto-Jozaki, Yumiko Doi-Tanaka, Haruka Takagi, Yuichiro Shirafuta, Yumiko Mihara, Ryo Maekawa, Toshiaki Taketani, Shun Sato, and Norihiro Sugino
utilization by melatonin treatment would lead to the downregulation of intermediates in the TCA cycle. Citrate is one of the intermediates and is used as the source for de novo lipogenesis (Martinez-Reyes & Chandel 2020 ). Melatonin treatment significantly
A. J. THODY, MARY F. COOPER, P. E. BOWDEN, D. MEDDIS, and S. SHUSTER
SUMMARY
The effects of α-MSH and testosterone propionate on sebum secretion, sebaceous gland volume, dermal lipogenesis, and preputial gland weight and lipogenesis were examined in hypophysectomized rats. Hypophysectomy reduced sebum secretion, sebaceous and preputial gland size, and dermal and preputial gland lipogenesis. The greatest effects were seen on the biosynthesis of wax esters and squalene. Testosterone propionate (TP) increased sebum secretion, sebaceous gland volume and preputial gland weight and lipogenic activity, but had no significant effect on the pattern of lipid labelling. α-MSH had no effect on sebaceous or preputial gland size, but increased sebum secretion and dermal lipogenesis, especially wax ester biosynthesis. When given together TP and α-MSH had a synergistic effect on sebum secretion and on dermal and preputial gland lipogenesis, and the pattern of lipid labelling was shifted towards normal. TP and α-MSH also showed synergism in increasing preputial gland weight, but together they had no greater effect on sebaceous gland volume than that achieved with TP alone.
These results suggest that TP and α-MSH have different actions on the sebaceous glands with α-MSH acting predominantly on lipogenesis and TP on cellular proliferation and turnover leading to an increase in gland size. Preputial glands differ from cutaneous sebaceous glands in their response to α-MSH and androgen which could be a reflection of their more specialized function.
Esther Dos Santos, Marie-Noëlle Dieudonné, Marie-Christine Leneveu, René Pecquery, Valérie Serazin, and Yves Giudicelli
-Dub & Corbetta 1997) and by increasing lipogenesis (lipoprotein lipase, fatty acid synthase activities; Shirling et al. 1981, Lacasa et al. 2001 ). Estrogens also exert multiple effects on adipose tissue metabolism. For example, high concentrations of
Andre Sarmento-Cabral, Mercedes del Rio-Moreno, Mari C Vazquez-Borrego, Mariyah Mahmood, Elena Gutierrez-Casado, Natalie Pelke, Grace Guzman, Papasani V Subbaiah, Jose Cordoba-Chacon, Shoshana Yakar, and Rhonda D Kineman
model of adult-onset, hepatocyte-specific knockdown of the GHR (aHepGHRkd; 10–12 week-old, GHR fl / fl mice treated with AAV8-TBGp-Cre). One week after aHepGHRkd, hepatic de novo lipogenesis (DNL) was increased in both male and female chow-fed mice
