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Anita Boelen Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Anne H van der Spek Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Flavia Bloise Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Emmely M de Vries Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Olga V Surovtseva Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Mieke van Beeren Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Mariette T Ackermans Department of Clinical Chemistry, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Joan Kwakkel Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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Eric Fliers Department of Endocrinology & Metabolism, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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-converting enzymes. Among the most important, thyroid hormone transporters are MCT8 and MCT10. MCT8 transports both T 4 and T 3 and is expressed in liver, muscle, kidney and in many brain areas ( Alkemade et al . 2005 , Heuer et al . 2005 ), whereas MCT10

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0483
Volume/Issue:
Volume 233: Issue 1
Free access
Lise M Sjøgaard-Frich Section for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, Denmark

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Morten Sølling Henriksen Section for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, Denmark

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Shi Min Lam Section for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, Denmark

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Frida Jolande Birkbak Section for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, Denmark

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Dominika Czaplinska Section for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, Denmark

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Mette Flinck Section for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, Denmark

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Stine Falsig Pedersen Section for Cell Biology and Physiology, Department of Biology, Faculty of Science, University of Copenhagen, Denmark

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Introduction Non-alcoholic fatty liver disease (NAFLD) encompasses a broad spectrum of diseases from reversible steatosis to non-alcoholic steatohepatitis (NASH), a severe condition characterized by inflammation, cell death, fibrosis, and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-24-0099
Volume/Issue:
Volume 263: Issue 2
Restricted access
Amanda J Genders Institute for Mental and Physical Health and Clinical Translation (iMPACT) and Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Victoria, Australia
Institute for Health and Sport (iHeS), Victoria University, Melbourne, Victoria, Australia

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Timothy Connor Institute for Mental and Physical Health and Clinical Translation (iMPACT) and Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Victoria, Australia

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Shona Morrison Institute for Mental and Physical Health and Clinical Translation (iMPACT) and Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Victoria, Australia

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Simon T Bond Institute for Mental and Physical Health and Clinical Translation (iMPACT) and Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Victoria, Australia
Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Brian G Drew Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Peter J Meikle Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Kirsten F Howlett Institute for Physical Activity and Nutrition (IPAN) and School of Exercise and Nutrition Science and Deakin University, Geelong, Victoria, Australia

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Sean L McGee Institute for Mental and Physical Health and Clinical Translation (iMPACT) and Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Victoria, Australia

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( Dirkx et al. 2012 ). These findings suggest a broader role for PKD in the control of glucose metabolism in various tissues. The liver is critical for the control of systemic glycemia and glucose metabolism. Under pre-prandial and fasting conditions

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0548
Volume/Issue:
Volume 246: Issue 3
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Claudia E Robert-Cooperman
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Grace C Dougan Department of Cell Biology, Department of Pediatrics, Microbiology and Molecular Biology, University of South Florida, 4202 East Fowler Avenue, BSF 206, Tampa, Florida 33620, USA

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Shari L Moak
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Mark G Athanason
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Melanie N Kuehl
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Harris Bell-Temin
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Stanley M Stevens Jr
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Brant R Burkhardt
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contrast to earlier findings, other investigators have detected the presence of PANDER in stomach, muscle, liver, and brain tissues ( Li et al . 2011 ). The family with sequence similarity 3 (FAM3) was identified using a computational algorithm known as

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0338
Volume/Issue:
Volume 220: Issue 3
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Rodrigo Martins Pereira Exercise Cell Biology Lab, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil

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Kellen Cristina da Cruz Rodrigues Exercise Cell Biology Lab, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil

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Marcella Ramos Sant’Ana Laboratory of Nutritional Genomics, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil

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Guilherme Francisco Peruca Exercise Cell Biology Lab, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil

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Ana Paula Morelli Multidisciplinary Laboratory of Food and Health, State University of Campinas, Faculty of Applied Sciences, Limeira, Brazil

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Fernando M Simabuco Multidisciplinary Laboratory of Food and Health, State University of Campinas, Faculty of Applied Sciences, Limeira, Brazil

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Adelino S R da Silva School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil
Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, Ribeirão Preto, São Paulo, Brazil

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Dennys Esper Cintra Laboratory of Nutritional Genomics, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil

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Eduardo Rochete Ropelle Laboratory of Molecular Biology of Exercise (LaBMEx), Faculty of Applied Sciences, State University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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José Rodrigo Pauli Laboratory of Molecular Biology of Exercise (LaBMEx), Faculty of Applied Sciences, State University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

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Leandro Pereira de Moura Exercise Cell Biology Lab, Faculty of Applied Sciences, State University of Campinas, Limeira, Brazil

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Introduction De novo synthesis of glucose from glycan precursors (non-sugars or non-carbohydrates), such as lactate, amino acids, and glycerol, is defined as gluconeogenesis. This synthesis is controlled by the liver and the cortex of the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0193
Volume/Issue:
Volume 247: Issue 2
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Ricardo J Samms School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Michelle Murphy School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Maxine J Fowler School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Scott Cooper School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Paul Emmerson School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Tamer Coskun School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Andrew C Adams School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Alexei Kharitonenkov School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Francis J P Ebling School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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Kostas Tsintzas School of Life Sciences, Lilly Research Laboratories, Chemistry Department, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK

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that these changes in the winter state are due to reduced daily food intake and increased whole-body daily energy expenditure ( Warner et al . 2010 ). We recently reported that plasma levels of FGF21, along with its local FGF21 protein content in liver

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0334
Volume/Issue:
Volume 227: Issue 1
Free access
Joachim M Weitzel Institute of Reproductive Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Torsten Viergutz Institute of Reproductive Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Dirk Albrecht Institute of Microbiology, Ernst-Moritz-Arndt-University, Greifswald, Germany

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Rupert Bruckmaier Veterinary Physiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

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Marion Schmicke Clinic for Cattle, Endocrinology Laboratory, University of Veterinary Medicine Hannover, Hannover, Germany

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Armin Tuchscherer Institute of Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Franziska Koch Institute of Nutritional Physiology ‘Oskar Kellner’, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Björn Kuhla Institute of Nutritional Physiology ‘Oskar Kellner’, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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likely that the TH system and TH-mediated signaling play a pivotal role in the control of substrate utilization and thus body temperature of heat-stressed cows. In order to distinguish between heat and energy intake-related effects, we analyzed the liver

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0066
Volume/Issue:
Volume 234: Issue 2
Open access
Elliott S Neal School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia

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Vinod Kumar School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia

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Karin Borges School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia

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James S M Cuffe School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia

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estimated to be 1.1–3.9 mg of which around 50% is stored in the liver ( Doets et al. 2013 ). Although even marginal B 12 deficiency can be harmful ( O’Leary & Samman 2010 ), B 12 intake and/or absorption must be inadequate for a prolonged period before

Article Type:
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DOI:
https://doi.org/10.1530/JOE-22-0158
Volume/Issue:
Volume 256: Issue 2
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S Khan Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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D E W Livingstone Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Centre for Discovery Brain Science, University of Edinburgh, Hugh Robson Building, Edinburgh, UK

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A Zielinska College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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C L Doig Department of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham, UK

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D F Cobice Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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C L Esteves Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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J T Y Man Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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N Z M Homer Mass Spectrometry Core Laboratory, Edinburgh Clinical Research Facility, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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J R Seckl Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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C L MacKay SIRCAMS, School of Chemistry, University of Edinburgh, Joseph Black Building, King's Buildings, Edinburgh, UK

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S P Webster Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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G G Lavery Department of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham, UK

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K E Chapman Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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B R Walker Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Clinical & Translational Research Institute, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK

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R Andrew Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Mass Spectrometry Core Laboratory, Edinburgh Clinical Research Facility, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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liver by arterio-venous sampling of production rates of d3F regenerated by 11βHSD1 ( Andrew et al. 2005 , Basu et al. 2006 , 2009 ) supports the view that, in humans, the majority of circulating cortisol arising from 11βHSD1-mediated glucocorticoid

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0034
Volume/Issue:
Volume 258: Issue 3
Open access
Elena Maneschi
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Linda Vignozzi
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Annamaria Morelli Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Tommaso Mello Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Sandra Filippi Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Ilaria Cellai
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Paolo Comeglio
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Erica Sarchielli Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Alessandra Calcagno Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Benedetta Mazzanti Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Roberto Vettor Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Gabriella Barbara Vannelli Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Luciano Adorini Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Medicine, Gastroenterology Unit, Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of Medicine, Hematology Unit, Intercept Pharmaceuticals, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, Florence, Italy

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Mario Maggi
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high triglyceride levels and low HDL cholesterol concentrations and hypertension ( Després & Lemieux 2006 ). Non-alcoholic fatty liver disease (NAFLD), a pathophysiological accumulation of lipids in the liver, is considered the hepatic hallmark of MetS

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0109
Volume/Issue:
Volume 218: Issue 2
Free access