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Elisa Keating Department of Biochemistry (U38-FCT), School of Biotechnology, Faculty of Nutrition and Food Sciences, Animal Facility, Department of Clinical Pathology, ISPUP-EPIUnit, CINTESIS – Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal
Department of Biochemistry (U38-FCT), School of Biotechnology, Faculty of Nutrition and Food Sciences, Animal Facility, Department of Clinical Pathology, ISPUP-EPIUnit, CINTESIS – Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

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Ana Correia-Branco Department of Biochemistry (U38-FCT), School of Biotechnology, Faculty of Nutrition and Food Sciences, Animal Facility, Department of Clinical Pathology, ISPUP-EPIUnit, CINTESIS – Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

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João R Araújo Department of Biochemistry (U38-FCT), School of Biotechnology, Faculty of Nutrition and Food Sciences, Animal Facility, Department of Clinical Pathology, ISPUP-EPIUnit, CINTESIS – Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

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Manuela Meireles Department of Biochemistry (U38-FCT), School of Biotechnology, Faculty of Nutrition and Food Sciences, Animal Facility, Department of Clinical Pathology, ISPUP-EPIUnit, CINTESIS – Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

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Rita Fernandes Department of Biochemistry (U38-FCT), School of Biotechnology, Faculty of Nutrition and Food Sciences, Animal Facility, Department of Clinical Pathology, ISPUP-EPIUnit, CINTESIS – Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal
Department of Biochemistry (U38-FCT), School of Biotechnology, Faculty of Nutrition and Food Sciences, Animal Facility, Department of Clinical Pathology, ISPUP-EPIUnit, CINTESIS – Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

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Luísa Guardão Department of Biochemistry (U38-FCT), School of Biotechnology, Faculty of Nutrition and Food Sciences, Animal Facility, Department of Clinical Pathology, ISPUP-EPIUnit, CINTESIS – Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

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João T Guimarães Department of Biochemistry (U38-FCT), School of Biotechnology, Faculty of Nutrition and Food Sciences, Animal Facility, Department of Clinical Pathology, ISPUP-EPIUnit, CINTESIS – Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal
Department of Biochemistry (U38-FCT), School of Biotechnology, Faculty of Nutrition and Food Sciences, Animal Facility, Department of Clinical Pathology, ISPUP-EPIUnit, CINTESIS – Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal
Department of Biochemistry (U38-FCT), School of Biotechnology, Faculty of Nutrition and Food Sciences, Animal Facility, Department of Clinical Pathology, ISPUP-EPIUnit, CINTESIS – Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

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Fátima Martel Department of Biochemistry (U38-FCT), School of Biotechnology, Faculty of Nutrition and Food Sciences, Animal Facility, Department of Clinical Pathology, ISPUP-EPIUnit, CINTESIS – Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

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Conceição Calhau Department of Biochemistry (U38-FCT), School of Biotechnology, Faculty of Nutrition and Food Sciences, Animal Facility, Department of Clinical Pathology, ISPUP-EPIUnit, CINTESIS – Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal
Department of Biochemistry (U38-FCT), School of Biotechnology, Faculty of Nutrition and Food Sciences, Animal Facility, Department of Clinical Pathology, ISPUP-EPIUnit, CINTESIS – Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

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protective effect against colorectal cancer risk ( Sie et al . 2011 ). Metabolic syndrome (MetS) is a condition of high and increasing prevalence worldwide that comprises a constellation of risk factors for cardiovascular disease and type 2 diabetes, such as

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0448
Volume/Issue:
Volume 224: Issue 3
Free access
Leke Wiering Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Junior Clinician Scientist Program, Berlin, Germany

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Frank Tacke Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany

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other diseases of the metabolic syndrome and is partly described as its hepatic manifestation. Thus, in the early stages, cardiovascular events represent the main cause of death in NAFLD, whereas in the later stages, liver-associated causes of death as

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0194
Volume/Issue:
Volume 256: Issue 1
Free access
Jocemara Patrícia Silva de Souza Parrela Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Ingridys Regina Borkenhagen Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Sarah Ramany Faria Salmeron Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Thalyne Aparecida Leite Lima Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Ginislene Dias Souza Miranda Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Hercules de Oliveira Costermani Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Camila Luiza Rodrigues dos Santos Ricken Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Ester Vieira Alves Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Rodrigo Mello Gomes Laboratory of Endocrine Physiology and Metabolism, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Goiás, Brazil

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Júlio Cezar de Oliveira Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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for infant health, we hypothesized that changes in maternal energy balance, even in the last third of pregnancy, can affect the content of these key hormones in milk, which may be underlying the origin of the metabolic syndrome that is commonly

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0427
Volume/Issue:
Volume 255: Issue 1
Free access
Laura L Gathercole Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Nikolaos Nikolaou Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Shelley E Harris Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Anastasia Arvaniti Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Toryn M Poolman Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Jonathan M Hazlehurst Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Denise V Kratschmar Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

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Marijana Todorčević Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Ahmad Moolla Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Niall Dempster Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Ryan C Pink Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Michael F Saikali Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

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Liz Bentley Mammalian Genetics Unit, Medical Research Council Harwell, Oxford, UK

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Trevor M Penning Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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Claes Ohlsson Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Carolyn L Cummins Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

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Matti Poutanen Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland

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Alex Odermatt Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

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Roger D Cox Mammalian Genetics Unit, Medical Research Council Harwell, Oxford, UK

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Jeremy W Tomlinson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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JM Morton NM Fievet C Kenyon CJ Holmes MC Staels B Seckl JR Mullins JJ 2004 Metabolic syndrome without obesity: hepatic overexpression of 11-hydroxysteroid dehydrogenase type 1 in transgenic mice . PNAS 101 7088 – 7093 . ( https

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0280
Volume/Issue:
Volume 253: Issue 3
Open access
L Francisco Lorenzo-Martín Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), CSIC-University of Salamanca, Salamanca, Spain

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Mauricio Menacho-Márquez Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), CSIC-University of Salamanca, Salamanca, Spain

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Salvatore Fabbiano Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain

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Omar Al-Massadi Departamento de Fisioloxía, University of Santiago de Compostela, Santiago de Compostela, Spain
Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, University of Santiago de Compostela, Santiago de Compostela, Spain
Centro de Investigación Biomédica en Red de Cáncer sobre la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), University of Santiago de Compostela, Santiago de Compostela, Spain

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Antonio Abad Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), CSIC-University of Salamanca, Salamanca, Spain

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Sonia Rodríguez-Fdez Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain

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María A Sevilla Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain

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María J Montero Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain

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Carlos Diéguez Departamento de Fisioloxía, University of Santiago de Compostela, Santiago de Compostela, Spain
Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, University of Santiago de Compostela, Santiago de Compostela, Spain
Centro de Investigación Biomédica en Red de Cáncer sobre la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), University of Santiago de Compostela, Santiago de Compostela, Spain

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Rubén Nogueiras Departamento de Fisioloxía, University of Santiago de Compostela, Santiago de Compostela, Spain
Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, University of Santiago de Compostela, Santiago de Compostela, Spain
Centro de Investigación Biomédica en Red de Cáncer sobre la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), University of Santiago de Compostela, Santiago de Compostela, Spain

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Xosé R Bustelo Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain

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case of borderline hypertension, neurogenic hypertension and the metabolic syndrome ( Moller & Kaufman 2005 , Mancia et al. 2007 , Lambert et al. 2010 ). This latter multiorgan spanning disease, together with the high incidence of sympathomimetic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0623
Volume/Issue:
Volume 240: Issue 3
Free access
Malin Hedengran Faulds
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Chunyan Zhao
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Karin Dahlman-Wright
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Jan-Åke Gustafsson Department of Biosciences and Nutrition, Center for Nuclear Receptors and Cell Signaling, Novum, Karolinska Institutet, S-141 83 Huddinge, Sweden

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–calmodulin-dependent kinases or activation of MAP kinase and phosphoinositide 3-kinase pathways. Estrogen signaling and metabolic syndrome The metabolic syndrome refers to a group of interrelated metabolic abnormalities that include disturbed glucose homeostasis, insulin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0044
Volume/Issue:
Volume 212: Issue 1
Free access
Giselle Adriana Abruzzese Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Maria Florencia Heber Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Silvana Rocio Ferreira Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Leandro Martin Velez Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Roxana Reynoso Laboratorio de Endocrinología, Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Omar Pedro Pignataro Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Alicia Beatriz Motta Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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hyperandrogenism, is related to hyperinsulinemia, dyslipidemia, insulin resistance (IR), cardiovascular disease and metabolic syndrome ( Demissie et al . 2008 , Amalfi et al . 2012 , Heber et al . 2013 ). However, how fetal programming impacts on different

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0471
Volume/Issue:
Volume 230: Issue 1
Free access
Chiung-Kuei Huang George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA

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Soo Ok Lee George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA

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Eugene Chang George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
Department of Medicine, Case Cardiovascular Institute Research Institute, Case Western Reserve University, Cleveland, OH, USA

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Haiyan Pang George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA

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Chawnshang Chang George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
Sex Hormone Research Center, China Medical University/Hospital, Taichung, Taiwan

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, suggesting the androgen levels might need to be balanced. Therefore, androgen/AR signaling might not be the suitable therapeutic target in heart failure patients. AR effects on the metabolic syndrome/diabetes and their impacts on CVDs Earlier we

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0518
Volume/Issue:
Volume 229: Issue 1
Free access
Jie Wei Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Xia Sun Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Yajie Chen Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Yuanyuan Li
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Liqiong Song
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Zhao Zhou
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Bing Xu
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Yi Lin Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Shunqing Xu
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Introduction Nonalcoholic fatty liver disease (NAFLD) is one of the typical hepatic manifestations of metabolic syndrome characterized by hepatic fat accumulation in the absence of excess alcohol consumption. NAFLD affects 15–40% of the general

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0356
Volume/Issue:
Volume 222: Issue 3
Free access
Fiona Roberts Functional Genetics and Development, The Roslin Institute, The University of Edinburgh, Edinburgh, UK

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Greg Markby Functional Genetics and Development, The Roslin Institute, The University of Edinburgh, Edinburgh, UK

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Scott Dillon Functional Genetics and Development, The Roslin Institute, The University of Edinburgh, Edinburgh, UK

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Colin Farquharson Functional Genetics and Development, The Roslin Institute, The University of Edinburgh, Edinburgh, UK

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Vicky E MacRae Functional Genetics and Development, The Roslin Institute, The University of Edinburgh, Edinburgh, UK

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. 1996 , Kirsch et al. 1997 , Nielsen et al. 2001 , Yoshiko et al. 2007 , Golub 2009 , Bourgine et al. 2011 ). Metabolic syndrome Metabolic syndrome is a global epidemic, with rates increasing alarmingly across both developed and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0460
Volume/Issue:
Volume 245: Issue 2
Free access