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L Nicol
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M-O Faure MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, UMR 6175 INRA-CNRS-Université de TOURS-Haras Nationaux, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK

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J R McNeilly
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J Fontaine MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, UMR 6175 INRA-CNRS-Université de TOURS-Haras Nationaux, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK

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C Taragnat MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, UMR 6175 INRA-CNRS-Université de TOURS-Haras Nationaux, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK

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A S McNeilly
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. Liu F Austin DA Mellon PL Olefsky JM Webster NJ 2002 GnRH activates ERK1/2 leading to the induction of c-fos and LHβ protein expression in LβT2 cells . Molecular Endocrinology 16 419 – 434 . Lou J Tu Y Li S Manske PR 2000 Involvement

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Shu-Fang Xia Wuxi School of Medicine, Jiangnan University, Wuxi, China
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China

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Xiao-Mei Duan State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China
Shandong Sport Training Center, Jinan, China

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Xiang-Rong Cheng State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China

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Li-Mei Chen Wuxi School of Medicine, Jiangnan University, Wuxi, China

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Yan-Jun Kang Wuxi School of Medicine, Jiangnan University, Wuxi, China

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Peng Wang COFCO Corporation Oilseeds Processing Division, Beijing, China

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Xue Tang State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China

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Yong-Hui Shi State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China

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Guo-Wei Le State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China

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Soares AF Lagarde M Geloen A 2008 Lou/C obesity-resistant rat exhibits hyperactivity, hypermetabolism, alterations in white adipose tissue cellularity, and lipid tissue profiles . Endocrinology 149 615 – 625 . ( doi:10.1210/en.2007

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Melanie Tran Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Golam Mostofa Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Michael Picard Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Jianguo Wu Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Li Wang Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA

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Dong-Ju Shin Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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used for all experimental procedures and were maintained on a 12 h light:12 h darkness cycle in a temperature (22°C) and humidity controlled (45–55%) environment with access to food and water ad libitum . SerpinA3N floxed mice on a C57BL6/J:129S

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Georgia Papacleovoulou The Queen's Medical Research Institute, Centre for Reproductive Biology, Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh EH16 4TJ, UK

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Hilary O D Critchley The Queen's Medical Research Institute, Centre for Reproductive Biology, Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh EH16 4TJ, UK

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Stephen G Hillier The Queen's Medical Research Institute, Centre for Reproductive Biology, Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh EH16 4TJ, UK

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J Ian Mason The Queen's Medical Research Institute, Centre for Reproductive Biology, Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh EH16 4TJ, UK

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gassed with 95% air, 5% CO 2 at 37 °C. Medium was refreshed every 7 days until cells reached confluence (2–4 weeks). A further advantage of 2- to 4-week cell culture in FBS-containing medium before experimentation was neutralisation of any disparity of

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L M McShane SAAD Centre for Pharmacy and Diabetes, University of Ulster, Coleraine, Northern Ireland, UK


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N Irwin SAAD Centre for Pharmacy and Diabetes, University of Ulster, Coleraine, Northern Ireland, UK

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D O’Flynn Conway Institute of Biomolecular and Biomedical Research, UCD, Belfield, Dublin 4, Ireland

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Z J Franklin SAAD Centre for Pharmacy and Diabetes, University of Ulster, Coleraine, Northern Ireland, UK


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C M Hewage Conway Institute of Biomolecular and Biomedical Research, UCD, Belfield, Dublin 4, Ireland

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F P M O’Harte SAAD Centre for Pharmacy and Diabetes, University of Ulster, Coleraine, Northern Ireland, UK

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experiments were response time of 2s, bandwidth of 1nm, scanning speed of 50nm/min, and a data pitch of 0.2nm. All spectra were acquired at 25°C by accumulation of 15 scans in a 1mm quartz cell, and the baseline corrected. Calculation of alpha-helical and beta

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David M Cartwright Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Lucy A Oakey Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Rachel S Fletcher Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Craig L Doig Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
School of Science and Technology, Nottingham Trent University, Nottingham, UK

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Silke Heising Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Dean P Larner Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Daniela Nasteska Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Caitlin E Berry Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Sam R Heaselgrave Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Christian Ludwig Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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David J Hodson Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Gareth G Lavery Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Antje Garten Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
Pediatric Research Center, Hospital for Child and Adolescent Medicine, Leipzig University, Leipzig, Germany

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al. 2019 ) were conducted with male C57BL/6J or C57BL/6JRj mice (B6J), a commonly used mouse model to study the effects of diet-induced obesity and glucose intolerance. A limitation of using these mice for metabolic studies is a deficiency in

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Patricia Joseph-Bravo Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), A.P. 510-3, Cuernavaca, Morelos 62250, Mexico

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Lorraine Jaimes-Hoy Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), A.P. 510-3, Cuernavaca, Morelos 62250, Mexico

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Jean-Louis Charli Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), A.P. 510-3, Cuernavaca, Morelos 62250, Mexico

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peptide PVN (mRNA) Arc (mRNA) TSH TT 4 TT 3 Cort References Trh Crh Agrp Npy Cart Pomc Bdnf Lou/C rat vs Wistar ↓ + ↑ * ↑ * ↑ * – + ↓ + ↑ ↑ ↓ – ↓ Mitchell et al

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Donato Calabrese
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Silvia Giatti
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Simone Romano
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Carla Porretta-Serapiglia Section of Biomedicine and Endocrinology, Neuromuscular Disease Unit, Department of Pharmacy and Center of Excellence for Biomedical Research, Instituto Cajal, Department of Pharmacological and Biomolecular Sciences, Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy

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Roberto Bianchi Section of Biomedicine and Endocrinology, Neuromuscular Disease Unit, Department of Pharmacy and Center of Excellence for Biomedical Research, Instituto Cajal, Department of Pharmacological and Biomolecular Sciences, Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy

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Marco Milanese Section of Biomedicine and Endocrinology, Neuromuscular Disease Unit, Department of Pharmacy and Center of Excellence for Biomedical Research, Instituto Cajal, Department of Pharmacological and Biomolecular Sciences, Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy

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Giambattista Bonanno Section of Biomedicine and Endocrinology, Neuromuscular Disease Unit, Department of Pharmacy and Center of Excellence for Biomedical Research, Instituto Cajal, Department of Pharmacological and Biomolecular Sciences, Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy

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Donatella Caruso
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Barbara Viviani
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Fabrizio Gardoni
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Luis Miguel Garcia-Segura Section of Biomedicine and Endocrinology, Neuromuscular Disease Unit, Department of Pharmacy and Center of Excellence for Biomedical Research, Instituto Cajal, Department of Pharmacological and Biomolecular Sciences, Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy

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Roberto Cosimo Melcangi
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receptor function by constitutively active protein kinase C . Molecular Pharmacology 54 1055 – 1063 . ( doi:10.1124/mol.54.6.1055 ) Yan JE Yuan W Lou X Zhu T 2012 Streptozotocin-induced diabetic hyperalgesia in rats is associated with

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Chengyuan Lin School of Biological Sciences, University of Hong Kong, Hong Kong
Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong
YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, Kunming, China

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Xue Jiang School of Biological Sciences, University of Hong Kong, Hong Kong

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Mulan He School of Biological Sciences, University of Hong Kong, Hong Kong

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Ling Zhao Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong

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Tao Huang Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong

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Zhaoxiang Bian Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong
YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, Kunming, China

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Anderson O L Wong School of Biological Sciences, University of Hong Kong, Hong Kong

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.5 to 2.0 kg were purchased from local markets and kept in a well-aerated 200-L aquaria under a 12-h L:12-h D photoperiod at 18 ± 2°C. The fish were sacrificed under anesthesia with 0.05% tricaine methanesulfonate (Sigma) followed by spinosectomy

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Hong-Zhi Sun
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Tong-Wei Yang Key Laboratory of Environment and Genes Related to Diseases, First Affiliated Hospital of Jilin University, Ministry of Education, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, People's Republic of China

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Wei-Jin Zang
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Shu-Fang Wu
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% air at 37 °C. Upon reaching monolayer confluence, the cells were split by treatment with 0.25% trypsin solution to give a final concentration of 5×10 4  cells/ml with PBS before starvation in 0.1% BSA (fraction V, Sigma), phenol red-free and serum

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