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Marta Toral Departamento de Farmacología, Facultad de Farmacia, Granada, Spain

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Rosario Jimenez Departamento de Farmacología, Facultad de Farmacia, Granada, Spain
Instituto de Investigación Biosanitaria GRANADA, Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain

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Sebastián Montoro-Molina Departamento de Ciencias de la Salud, Universidad de Jaén, Jaén, Spain

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Miguel Romero Departamento de Farmacología, Facultad de Farmacia, Granada, Spain
Instituto de Investigación Biosanitaria GRANADA, Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain

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Rosemary Wangensteen Departamento de Ciencias de la Salud, Universidad de Jaén, Jaén, Spain

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Juan Duarte Departamento de Farmacología, Facultad de Farmacia, Granada, Spain
Instituto de Investigación Biosanitaria GRANADA, Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain

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Félix Vargas Instituto de Investigación Biosanitaria GRANADA, Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain
Departamento de Fisiología, Facultad de Medicina, Granada, Spain

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), mitogen-activated protein kinase (MAPK) and intracellular calcium mobilization signaling pathways as underlying mechanisms. Material and methods Culture of HUVECs Endothelial cells were isolated from human umbilical cord veins using a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0229
Volume/Issue:
Volume 239: Issue 1
Free access
H McNeill School of Biological Sciences, Queen Mary, University of London and
William Harvey Research Institute, Barts and the London, Queen Mary’s School of Medicine and Dentistry, University of London, London, UK

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E Whitworth School of Biological Sciences, Queen Mary, University of London and
William Harvey Research Institute, Barts and the London, Queen Mary’s School of Medicine and Dentistry, University of London, London, UK

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G P Vinson School of Biological Sciences, Queen Mary, University of London and
William Harvey Research Institute, Barts and the London, Queen Mary’s School of Medicine and Dentistry, University of London, London, UK

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J P Hinson School of Biological Sciences, Queen Mary, University of London and
William Harvey Research Institute, Barts and the London, Queen Mary’s School of Medicine and Dentistry, University of London, London, UK

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al. 1996 ). The AT1 receptor in the zona glomerulosa signals via the calcium/inositol trisphosphate second messenger pathway ( Spät 1988 , Catt et al. 1988 , Rossig et al. 1996 ). However, angiotensin II is also known to stimulate the MAP

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06347
Volume/Issue:
Volume 187: Issue 1
Free access
Shu-Ju Chang Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
Department of Pathology, Mackay Memorial Hospital and Mackay Medicine, Nursing and Management College, Taipei, Taiwan ROC
Department of Physiology and Department of Traditional Chinese Medicine, Taipei Medical University Hospital, Taipei, Taiwan ROC
Department of Obstetrics and Gynecology, Taipei Medical University, 252 Wu-Xing Street, Xin-Yi District, Taipei, 110, Taiwan ROC

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Tao-Yeuan Wang Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
Department of Pathology, Mackay Memorial Hospital and Mackay Medicine, Nursing and Management College, Taipei, Taiwan ROC
Department of Physiology and Department of Traditional Chinese Medicine, Taipei Medical University Hospital, Taipei, Taiwan ROC
Department of Obstetrics and Gynecology, Taipei Medical University, 252 Wu-Xing Street, Xin-Yi District, Taipei, 110, Taiwan ROC

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Yi-Hsuan Lee Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
Department of Pathology, Mackay Memorial Hospital and Mackay Medicine, Nursing and Management College, Taipei, Taiwan ROC
Department of Physiology and Department of Traditional Chinese Medicine, Taipei Medical University Hospital, Taipei, Taiwan ROC
Department of Obstetrics and Gynecology, Taipei Medical University, 252 Wu-Xing Street, Xin-Yi District, Taipei, 110, Taiwan ROC

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Chen-Jei Tai Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
Department of Pathology, Mackay Memorial Hospital and Mackay Medicine, Nursing and Management College, Taipei, Taiwan ROC
Department of Physiology and Department of Traditional Chinese Medicine, Taipei Medical University Hospital, Taipei, Taiwan ROC
Department of Obstetrics and Gynecology, Taipei Medical University, 252 Wu-Xing Street, Xin-Yi District, Taipei, 110, Taiwan ROC

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intracellular signals ( Brunet & Pouyssegur 1997 ). When activated, ERK1 and ERK2 (also known as p42 mapk and p44 mapk respectively) may be imported into the nucleus and phosphorylate a variety of substrates, which have been implicated in the control of cell

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0168
Volume/Issue:
Volume 193: Issue 3
Free access
Andréa M Caricilli Department of Internal Medicine, State University of Campinas, 13081-970 Campinas, SP, Brazil

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Paula H Nascimento Department of Internal Medicine, State University of Campinas, 13081-970 Campinas, SP, Brazil

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José R Pauli Department of Internal Medicine, State University of Campinas, 13081-970 Campinas, SP, Brazil

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Daniela M L Tsukumo Department of Internal Medicine, State University of Campinas, 13081-970 Campinas, SP, Brazil

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Lício A Velloso Department of Internal Medicine, State University of Campinas, 13081-970 Campinas, SP, Brazil

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José B Carvalheira Department of Internal Medicine, State University of Campinas, 13081-970 Campinas, SP, Brazil

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Mário J A Saad Department of Internal Medicine, State University of Campinas, 13081-970 Campinas, SP, Brazil

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decreased in those treated with TLR2 ASON. Total MAPK8 protein expression was the same in all samples ( Fig. 2 E). Effect of TLR2 ASON on insulin signaling in gastrocnemius muscle In mice fed on standard chow, treatment with TLR2 ASON did not change insulin

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0354
Volume/Issue:
Volume 199: Issue 3
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Hyo-Eun Kim
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Sung-E Choi
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Soo-Jin Lee
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Ji-Hyun Lee
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Youn-Jung Lee
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Sang Sun Kang Institute for Medical Science, Division of Science Education, Korea National University of Education, Ajou University School of Medicine, 442-749 Suwon, Republic of Korea

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Jaesun Chun Institute for Medical Science, Division of Science Education, Korea National University of Education, Ajou University School of Medicine, 442-749 Suwon, Republic of Korea

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Yup Kang
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inhibitors of JNK, p38, NF-κB, inducible nitric oxide synthase (iNOS), and reactive oxygen species (ROS) on TNF-α-induced GSIS inhibition were investigated. Lastly, the involvement of JNK/p38 MAPK and NF-κB inflammatory signals in GSIS inhibition was studied

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0131
Volume/Issue:
Volume 198: Issue 3
Free access
Tianxue Zhao Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Qian Li Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Qianyun Mao Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Kaida Mu Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Chen Wang Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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to total levels (right). Data represent means ± s.e.m . , * P < 0.05, ** P < 0.01(Student's t-test). nNOS overexpression activated p38 MAPK signaling pathway in HepG2 cells Previous studies have reported that p38MAPK activation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0322
Volume/Issue:
Volume 248: Issue 3
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Maria E C Amaral
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Daniel A Cunha
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Gabriel F Anhê
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Mirian Ueno
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Everardo M Carneiro
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Lício A Velloso
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Silvana Bordin
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Antonio C Boschero
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To investigate the participation of SHC and the MAPK cascade in cellular signaling, groups of 300 islets were lysed, separated by SDS-PAGE and blotted with anti-SHC and anti-ERK1/2 antibodies, and anti-phospho-ERK1/2 antibody. The islet extracts were

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05547
Volume/Issue:
Volume 183: Issue 3
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Min Hu Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Traditional Chinese Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

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Yuehui Zhang Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Obstetrics and Gynecology, Key Laboratory and Unit of Infertility in Chinese Medicine, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China

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Jiaxing Feng Department of Obstetrics and Gynecology, Key Laboratory and Unit of Infertility in Chinese Medicine, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China

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Xue Xu Department of Obstetrics and Gynecology, Key Laboratory and Unit of Infertility in Chinese Medicine, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China

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Jiao Zhang Department of Acupuncture and Moxibustion, Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China

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Wei Zhao Department of Obstetrics and Gynecology, Key Laboratory and Unit of Infertility in Chinese Medicine, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China

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Xiaozhu Guo Department of Obstetrics and Gynecology, Key Laboratory and Unit of Infertility in Chinese Medicine, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China

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Juan Li Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Traditional Chinese Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

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Edvin Vestin Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Peng Cui Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Integrative Medicine and Neurobiology, State Key Lab of Medical Neurobiology, Shanghai Medical College and Institute of Acupuncture Research (WHO Collaborating Center for Traditional Medicine), Institute of Brain Science, Fudan University, Shanghai, China
Institute of Integrative Medicine of Fudan University, Shanghai, China

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Xin Li Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Gynecology Obstetrics and Gynecology, Hospital of Fudan University, Shanghai, China
Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China

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Xiao-ke Wu Department of Obstetrics and Gynecology, Key Laboratory and Unit of Infertility in Chinese Medicine, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China

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Mats Brännström Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Linus R Shao Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Håkan Billig Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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compared to PCOS patients who still ovulate and to non-PCOS patients ( Quezada et al. 2006 , Margarit et al. 2010 ). Additionally, PGR activity is also modulated by the cytoplasmic mitogen-activated protein kinase (MAPK)/extracellular signal

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0086
Volume/Issue:
Volume 237: Issue 2
Free access
A Scarlett Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary, Centre for Endocrinology, University of London, Charterhouse Square, London EC1M 6BQ, UK

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M P Parsons Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary, Centre for Endocrinology, University of London, Charterhouse Square, London EC1M 6BQ, UK

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P L Hanson Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary, Centre for Endocrinology, University of London, Charterhouse Square, London EC1M 6BQ, UK

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K K Sidhu Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary, Centre for Endocrinology, University of London, Charterhouse Square, London EC1M 6BQ, UK

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T P Milligan Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary, Centre for Endocrinology, University of London, Charterhouse Square, London EC1M 6BQ, UK

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J M Burrin Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary, Centre for Endocrinology, University of London, Charterhouse Square, London EC1M 6BQ, UK

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and initiate rapid activation of MAPK signal transduction cascades in human cell lines. Several in vitro studies have demonstrated direct effects of thyroid hormones on cells of the osteoblast lineage. In response to T 3 , osteoblasts are able to

Article Type:
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DOI:
https://doi.org/10.1677/JOE-07-0344
Volume/Issue:
Volume 196: Issue 3
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Mina Takahashi Medicine and Clinical Science, Departments of

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Fumio Otsuka Medicine and Clinical Science, Departments of

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Tomoko Miyoshi Medicine and Clinical Science, Departments of

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Hiroyuki Otani Medicine and Clinical Science, Departments of

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Junko Goto Medicine and Clinical Science, Departments of

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Misuzu Yamashita Medicine and Clinical Science, Departments of

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Toshio Ogura Medicine and Clinical Science, Departments of

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Hirofumi Makino Medicine and Clinical Science, Departments of

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Hiroyoshi Doihara Medicine and Clinical Science, Departments of

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subjected to SDS-PAGE/immunoblotting analysis as we reported earlier ( Otani et al . 2007 ), using anti-phospho- and anti-total-extracellular signal-regulated kinase (ERK) 1/2 MAPK antibody (Cell Signaling Technology, Inc., Beverly, MA, USA), anti

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0226
Volume/Issue:
Volume 199: Issue 3
Free access