Search Results
Lucia Zhang
Lucia Zhang
Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Search for other papers by Lucia Zhang in
Google Scholar
PubMed
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Search for other papers by Lucia Zhang in
Google Scholar
PubMed
Kathy K Lee
Kathy K Lee
Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Search for other papers by Kathy K Lee in
Google Scholar
PubMed
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Search for other papers by Kathy K Lee in
Google Scholar
PubMed
Kim S Sugamori
Kim S Sugamori
Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
Search for other papers by Kim S Sugamori in
Google Scholar
PubMed
Search for other papers by Kim S Sugamori in
Google Scholar
PubMed
Marc D Grynpas
Marc D Grynpas
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Search for other papers by Marc D Grynpas in
Google Scholar
PubMed
Search for other papers by Marc D Grynpas in
Google Scholar
PubMed
Jane Mitchell
Jane Mitchell
Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
Search for other papers by Jane Mitchell in
Google Scholar
PubMed
Search for other papers by Jane Mitchell in
Google Scholar
PubMed
cPTH ( Fig. 5B ). Since Wnt signalling is known to be required for osteoblast differentiation, we examined mRNA levels encoding several proteins involved in Wnt pathways in metaphyseal trabecular bone samples ( Fig. 5C , D and E ). Sost, encoding
Jiju Wang
Jiju Wang
Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, People’s Republic of China
Search for other papers by Jiju Wang in
Google Scholar
PubMed
Search for other papers by Jiju Wang in
Google Scholar
PubMed
Yunhui Tang
Yunhui Tang
Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, People’s Republic of China
Search for other papers by Yunhui Tang in
Google Scholar
PubMed
Search for other papers by Yunhui Tang in
Google Scholar
PubMed
Songcun Wang
Songcun Wang
Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, People’s Republic of China
Search for other papers by Songcun Wang in
Google Scholar
PubMed
Search for other papers by Songcun Wang in
Google Scholar
PubMed
Liyuan Cui
Liyuan Cui
Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, People’s Republic of China
Search for other papers by Liyuan Cui in
Google Scholar
PubMed
Search for other papers by Liyuan Cui in
Google Scholar
PubMed
Dajin Li
Dajin Li
Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, People’s Republic of China
Search for other papers by Dajin Li in
Google Scholar
PubMed
Search for other papers by Dajin Li in
Google Scholar
PubMed
Meirong Du
Meirong Du
Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, People’s Republic of China
Search for other papers by Meirong Du in
Google Scholar
PubMed
Search for other papers by Meirong Du in
Google Scholar
PubMed
functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the human . Journal of Biological Chemistry 282 31725 – 3 173 2 . ( https://doi.org/10.1074/jbc.M704723200 ) Li MQ Hou XF Lv SJ Meng
Weijuan Shao
Weijuan Shao
Divsion of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada
Banting and Best Diabetes Centre, Department of Medicine, University of Toronto, Toronto, Canada
Search for other papers by Weijuan Shao in
Google Scholar
PubMed
Banting and Best Diabetes Centre, Department of Medicine, University of Toronto, Toronto, Canada
Search for other papers by Weijuan Shao in
Google Scholar
PubMed
Wenjuan Liu
Wenjuan Liu
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
Search for other papers by Wenjuan Liu in
Google Scholar
PubMed
Search for other papers by Wenjuan Liu in
Google Scholar
PubMed
Ping Liang
Ping Liang
Department of Biological Sciences, Brock University, St. Catherine, Canada
Search for other papers by Ping Liang in
Google Scholar
PubMed
Search for other papers by Ping Liang in
Google Scholar
PubMed
Zhuolun Song
Zhuolun Song
Divsion of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada
Banting and Best Diabetes Centre, Department of Medicine, University of Toronto, Toronto, Canada
Department of Physiology, University of Toronto, Toronto, Canada
Search for other papers by Zhuolun Song in
Google Scholar
PubMed
Banting and Best Diabetes Centre, Department of Medicine, University of Toronto, Toronto, Canada
Department of Physiology, University of Toronto, Toronto, Canada
Search for other papers by Zhuolun Song in
Google Scholar
PubMed
Odisho Israel
Odisho Israel
Divsion of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada
Search for other papers by Odisho Israel in
Google Scholar
PubMed
Search for other papers by Odisho Israel in
Google Scholar
PubMed
Gerald J Prud’homme
Gerald J Prud’homme
Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, Toronto, Canada
Search for other papers by Gerald J Prud’homme in
Google Scholar
PubMed
Search for other papers by Gerald J Prud’homme in
Google Scholar
PubMed
Qinghua Wang
Qinghua Wang
Banting and Best Diabetes Centre, Department of Medicine, University of Toronto, Toronto, Canada
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, Toronto, Canada
Search for other papers by Qinghua Wang in
Google Scholar
PubMed
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, Toronto, Canada
Search for other papers by Qinghua Wang in
Google Scholar
PubMed
Tianru Jin
Tianru Jin
Divsion of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada
Banting and Best Diabetes Centre, Department of Medicine, University of Toronto, Toronto, Canada
Department of Physiology, University of Toronto, Toronto, Canada
Search for other papers by Tianru Jin in
Google Scholar
PubMed
Banting and Best Diabetes Centre, Department of Medicine, University of Toronto, Toronto, Canada
Department of Physiology, University of Toronto, Toronto, Canada
Search for other papers by Tianru Jin in
Google Scholar
PubMed
further expands our view on metabolic functions of the developmental Wnt signaling pathway effector during adulthood ( Jin 2016 ). PKA-mediated β-cat S675 phosphorylation was initially reported by Hino et al. (2005) . Such phosphorylation was then
DR Brigstock
DR Brigstock
Search for other papers by DR Brigstock in
Google Scholar
PubMed
Search for other papers by DR Brigstock in
Google Scholar
PubMed
The CCN family comprises cysteine-rich 61 (CYR61/CCN1), connective tIssue growth factor (CTGF/CCN2), nephroblastoma overexpressed (NOV/CCN3), and Wnt-induced secreted proteins-1 (WISP-1/CCN4), -2 (WISP-2/CCN5) and -3 (WISP-3/CCN6). These proteins stimulate mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types. Many of these activities probably occur through the ability of CCN proteins to bind and activate cell surface integrins. Accumulating evidence supports a role for these factors in endocrine pathways and endocrine-related processes. To illustrate the broad role played by the CCN family in basic and clinical endocrinology, this Article highlights the relationship between CCN proteins and hormone action, skeletal growth, placental angiogenesis, IGF-binding proteins and diabetes-induced fibrosis.
Yarikipati Prathibha
Yarikipati Prathibha
Department of Animal Biology, School of Life Sciences, University of Hyderabad, P.O. Central University, Hyderabad, Telangana, India
Search for other papers by Yarikipati Prathibha in
Google Scholar
PubMed
Search for other papers by Yarikipati Prathibha in
Google Scholar
PubMed
Balasubramanian Senthilkumaran
Balasubramanian Senthilkumaran
Department of Animal Biology, School of Life Sciences, University of Hyderabad, P.O. Central University, Hyderabad, Telangana, India
Search for other papers by Balasubramanian Senthilkumaran in
Google Scholar
PubMed
Search for other papers by Balasubramanian Senthilkumaran in
Google Scholar
PubMed
Introduction Ovarian development is regulated by various signaling pathways along with other growth factors. Wnt/Frizzled pathways play an important role in ovarian embryogenesis, folliculogenesis and possibly ovulation and luteinization in
Claes Ohlsson
Claes Ohlsson
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
Search for other papers by Claes Ohlsson in
Google Scholar
PubMed
Search for other papers by Claes Ohlsson in
Google Scholar
PubMed
Petra Henning
Petra Henning
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
Search for other papers by Petra Henning in
Google Scholar
PubMed
Search for other papers by Petra Henning in
Google Scholar
PubMed
Karin H Nilsson
Karin H Nilsson
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
Search for other papers by Karin H Nilsson in
Google Scholar
PubMed
Search for other papers by Karin H Nilsson in
Google Scholar
PubMed
Jianyao Wu
Jianyao Wu
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
Search for other papers by Jianyao Wu in
Google Scholar
PubMed
Search for other papers by Jianyao Wu in
Google Scholar
PubMed
Karin L Gustafsson
Karin L Gustafsson
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
Search for other papers by Karin L Gustafsson in
Google Scholar
PubMed
Search for other papers by Karin L Gustafsson in
Google Scholar
PubMed
Klara Sjögren
Klara Sjögren
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
Search for other papers by Klara Sjögren in
Google Scholar
PubMed
Search for other papers by Klara Sjögren in
Google Scholar
PubMed
Anna Törnqvist
Anna Törnqvist
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
Search for other papers by Anna Törnqvist in
Google Scholar
PubMed
Search for other papers by Anna Törnqvist in
Google Scholar
PubMed
Antti Koskela
Antti Koskela
Department of Anatomy and Cell Biology, Institute of Cancer Research and Translational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland
Search for other papers by Antti Koskela in
Google Scholar
PubMed
Search for other papers by Antti Koskela in
Google Scholar
PubMed
Fu-Ping Zhang
Fu-Ping Zhang
Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland
Search for other papers by Fu-Ping Zhang in
Google Scholar
PubMed
Search for other papers by Fu-Ping Zhang in
Google Scholar
PubMed
Marie K Lagerquist
Marie K Lagerquist
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
Search for other papers by Marie K Lagerquist in
Google Scholar
PubMed
Search for other papers by Marie K Lagerquist in
Google Scholar
PubMed
Matti Poutanen
Matti Poutanen
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland
Search for other papers by Matti Poutanen in
Google Scholar
PubMed
Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Turku, Finland
Search for other papers by Matti Poutanen in
Google Scholar
PubMed
Juha Tuukkanen
Juha Tuukkanen
Department of Anatomy and Cell Biology, Institute of Cancer Research and Translational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland
Search for other papers by Juha Tuukkanen in
Google Scholar
PubMed
Search for other papers by Juha Tuukkanen in
Google Scholar
PubMed
Ulf H Lerner
Ulf H Lerner
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
Search for other papers by Ulf H Lerner in
Google Scholar
PubMed
Search for other papers by Ulf H Lerner in
Google Scholar
PubMed
Sofia Movérare-Skrtic
Sofia Movérare-Skrtic
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Gothenburg, Sweden
Search for other papers by Sofia Movérare-Skrtic in
Google Scholar
PubMed
Search for other papers by Sofia Movérare-Skrtic in
Google Scholar
PubMed
reported to affect all aspects of skeletal development, including craniofacial, limb and joint formation. In addition, mutations in several members of the WNT signaling pathways result in skeletal malformations in humans and mice ( Balemans et al . 2001
Virginia Rider
Virginia Rider
Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA
Search for other papers by Virginia Rider in
Google Scholar
PubMed
Search for other papers by Virginia Rider in
Google Scholar
PubMed
Alex Talbott
Alex Talbott
Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA
Search for other papers by Alex Talbott in
Google Scholar
PubMed
Search for other papers by Alex Talbott in
Google Scholar
PubMed
Anuradha Bhusri
Anuradha Bhusri
Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA
Search for other papers by Anuradha Bhusri in
Google Scholar
PubMed
Search for other papers by Anuradha Bhusri in
Google Scholar
PubMed
Zach Krumsick
Zach Krumsick
Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA
Search for other papers by Zach Krumsick in
Google Scholar
PubMed
Search for other papers by Zach Krumsick in
Google Scholar
PubMed
Sierra Foster
Sierra Foster
Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA
Search for other papers by Sierra Foster in
Google Scholar
PubMed
Search for other papers by Sierra Foster in
Google Scholar
PubMed
Joshua Wormington
Joshua Wormington
Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA
Search for other papers by Joshua Wormington in
Google Scholar
PubMed
Search for other papers by Joshua Wormington in
Google Scholar
PubMed
Bruce F Kimler
Bruce F Kimler
Department of Radiation Oncology, The University of Kansas Medical Center, Kansas City, Kansas, USA
Search for other papers by Bruce F Kimler in
Google Scholar
PubMed
Search for other papers by Bruce F Kimler in
Google Scholar
PubMed
). The Wnt/β-catenin pathway plays a critical function at the site of implantation as inhibition of this signaling pathway interferes with the process ( Mohamed et al . 2005 ). Several WNT proteins (WNT4, WNT5A, WNT6, and WNT7A) are highly expressed in
Thomas Funck-Brentano
Thomas Funck-Brentano
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Search for other papers by Thomas Funck-Brentano in
Google Scholar
PubMed
Search for other papers by Thomas Funck-Brentano in
Google Scholar
PubMed
Karin H Nilsson
Karin H Nilsson
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Search for other papers by Karin H Nilsson in
Google Scholar
PubMed
Search for other papers by Karin H Nilsson in
Google Scholar
PubMed
Robert Brommage
Robert Brommage
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Search for other papers by Robert Brommage in
Google Scholar
PubMed
Search for other papers by Robert Brommage in
Google Scholar
PubMed
Petra Henning
Petra Henning
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Search for other papers by Petra Henning in
Google Scholar
PubMed
Search for other papers by Petra Henning in
Google Scholar
PubMed
Ulf H Lerner
Ulf H Lerner
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Search for other papers by Ulf H Lerner in
Google Scholar
PubMed
Search for other papers by Ulf H Lerner in
Google Scholar
PubMed
Antti Koskela
Antti Koskela
Unit of Cancer Research and Translational Medicine, MRC Oulu and Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland
Search for other papers by Antti Koskela in
Google Scholar
PubMed
Search for other papers by Antti Koskela in
Google Scholar
PubMed
Juha Tuukkanen
Juha Tuukkanen
Unit of Cancer Research and Translational Medicine, MRC Oulu and Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland
Search for other papers by Juha Tuukkanen in
Google Scholar
PubMed
Search for other papers by Juha Tuukkanen in
Google Scholar
PubMed
Martine Cohen-Solal
Martine Cohen-Solal
BIOSCAR UMRS 1132, Université Paris Diderot, Sorbonne Paris Cité, INSERM, Paris, France
Search for other papers by Martine Cohen-Solal in
Google Scholar
PubMed
Search for other papers by Martine Cohen-Solal in
Google Scholar
PubMed
Sofia Movérare-Skrtic
Sofia Movérare-Skrtic
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Search for other papers by Sofia Movérare-Skrtic in
Google Scholar
PubMed
Search for other papers by Sofia Movérare-Skrtic in
Google Scholar
PubMed
Claes Ohlsson
Claes Ohlsson
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Search for other papers by Claes Ohlsson in
Google Scholar
PubMed
Search for other papers by Claes Ohlsson in
Google Scholar
PubMed
Introduction WNT ligands belong to a family of 19 secreted cysteine-rich glycoproteins that are essential for development and tissue homeostasis ( Clevers & Nusse 2012 ). They signal through both the canonical WNT-β-catenin pathway and the
Zuzana Saidak
Zuzana Saidak
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
Search for other papers by Zuzana Saidak in
Google Scholar
PubMed
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
Search for other papers by Zuzana Saidak in
Google Scholar
PubMed
Carole Le Henaff
Carole Le Henaff
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
Search for other papers by Carole Le Henaff in
Google Scholar
PubMed
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
Search for other papers by Carole Le Henaff in
Google Scholar
PubMed
Sofia Azzi
Sofia Azzi
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
Search for other papers by Sofia Azzi in
Google Scholar
PubMed
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
Search for other papers by Sofia Azzi in
Google Scholar
PubMed
Caroline Marty
Caroline Marty
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
Search for other papers by Caroline Marty in
Google Scholar
PubMed
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
Search for other papers by Caroline Marty in
Google Scholar
PubMed
Pierre J Marie
Pierre J Marie
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
Search for other papers by Pierre J Marie in
Google Scholar
PubMed
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
Search for other papers by Pierre J Marie in
Google Scholar
PubMed
with other signalling pathways. Wnt signalling is an important regulator of osteoblast proliferation, differentiation and survival ( Baron & Kneissel 2013 ). The Wnt canonical pathway involves Wnt binding to the co-receptors LRP5 and Frizzled, leading
Timothy J Dreyer
Timothy J Dreyer
Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK
Search for other papers by Timothy J Dreyer in
Google Scholar
PubMed
Search for other papers by Timothy J Dreyer in
Google Scholar
PubMed
Jacob AC Keen
Jacob AC Keen
Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK
Search for other papers by Jacob AC Keen in
Google Scholar
PubMed
Search for other papers by Jacob AC Keen in
Google Scholar
PubMed
Leah M Wells
Leah M Wells
Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK
Search for other papers by Leah M Wells in
Google Scholar
PubMed
Search for other papers by Leah M Wells in
Google Scholar
PubMed
Scott J Roberts
Scott J Roberts
Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK
Search for other papers by Scott J Roberts in
Google Scholar
PubMed
Search for other papers by Scott J Roberts in
Google Scholar
PubMed
negative regulator of the Wnt/β-catenin signalling pathway (reviewed by Holdsworth et al. 2019 ). Sclerostin achieves this through inhibition of wingless-related integration site (Wnt)–ligand interaction with low-density lipoprotein receptor protein 4
