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Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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also results in bone loss ( Spector et al . 2009 ). In addition to bone loss, bed rest results in an increase in marrow adipose tissue (MAT) ( Trudel et al . 2009 ). MAT has not been investigated in astronauts but has been shown to increase in rats
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increase serum leptin levels, despite increases in bone marrow and brown fat content ( Rzonca et al. 2004 ). Therefore, it is likely that a change in leptin expression does occur in adipose tissue, but is not reflected in circulating serum leptin levels
Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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wildtype (WT) mice. Nevertheless, bone length and cancellous bone microarchitecture, cell measurements of bone formation (osteoblast perimeter), bone resorption (osteoclast perimeter), and marrow adiposity (adipocyte density), and dynamic measurements of
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Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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and greater marrow adiposity compared to wild-type (WT) mice ( Steppan et al . 2000 , Ealey et al . 2006 , Iwaniec et al . 2007 , Turner et al . 2014 , Lindenmaier et al . 2016 ). However, differences in cancellous bone volume fraction between
Bone Pathology Unit, Angers University Hospital, Angers Cedex, France
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Rheumatology Department, Angers University Hospital, Angers Cedex, France
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Bone Pathology Unit, Angers University Hospital, Angers Cedex, France
Service Commun d’Imageries et d’Analyses Microscopiques, SCIAM, SFR 42-08, Université d’Angers, IRIS-IBS Institut de Biologie en Santé, CHU d’Angers, Angers Cedex, France
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1 mm centred at the midshaft tibia. All histomorphometrical parameters were determined according to guidelines and nomenclature proposed by the American Society for Bone and Mineral Research ( Bouxsein et al. 2010 ). Marrow adipose tissue
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euthyroid subjects . Clinical Endocrinology 64 125 – 128 . Meunier P Aaron J Edouard C Vignon G 1971 Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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tissue and marrow phase. Cancellous bone was separated from the cortical regions by semi-automatically drawn contours. A total of 120 slices starting from about 0.1 mm distal to growth plate, constituting 0.70 mm of length, was evaluated for trabecular
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Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
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Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
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Department of Orthopaedic Surgery, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
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Department of Physiology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
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Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
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. Analysis of bone marrow adiposity Bone marrow adiposity was determined as previously described ( Refaey et al. 2017 ). Briefly, tibiae were decalcified in 15% EDTA, embedded in paraffin and sectioned for histology (5 microns thick). One slide per mouse
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becomes harmful for bones and/or muscle ( Liu et al . 2014 ). Bone marrow adipose tissue (MAT) increases with aging, obesity and in osteoporosis, thereby also interconnecting bone and fat tissues. Some suggest that MAT should be considered a biomarker
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Department of Research, The University of Connecticut School of Medicine, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105-1299, USA
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deletion in vivo impairs the formation of white and brown adipose tissue ( Tanaka et al . 1997 , Hata et al . 2005 ). Accordingly, male Cebpb null mice exhibited reduced total body fat. The Cebpb deletion did not affect the number of bone marrow