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Introduction The endocrine axis is forever dynamic. The synthesis and secretion of hormones change predictably over the course of hours, months, years and lifetimes ( Hastings 1991 , Czeisler & Klerman 1999 ). The most dramatic
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BIO5 Institute, University of Arizona, Tucson, Arizona, USA
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nervous system. Introduction Energy and glucose homeostasis are tightly controlled by coordinated neural and endocrine signals that facilitate tissue crosstalk and central nervous system (CNS) integration to regulate food intake, energy expenditure
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sheep model has enabled a detailed examination of how the fetal cardiac environment shapes cardiomyocyte growth, maturation and endowment. The purpose of this review is to summarize what is known about endocrine and other regulators of growth and
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Physiology and Pharmacology, Western University, London, Ontario, Canada
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, Fasoulakis et al. 2023 ). Both conditions adversely affect the development of endocrine pancreas cells, resulting in future deficiencies (e.g. reduced beta cells) and reduced plasticity during times of metabolic demand, which can contribute to the
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all species, the ability to precisely regulate energy production and expenditure is critical. In a once unstable environment, mammals evolved intricate paracrine, autocrine and endocrine signalling pathways that coordinate energy expenditure and
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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IGF2 with the IGF1 receptor (IGF1R) on the islet cell surface. For these reasons, we believe that IGF2 represents the more promising endocrine growth factor to improve islet transplant survival. This review provides an overview of the current
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and absorb water. As in mammals, the endocrine system plays a central role in such homeostatic regulation in fish ( McCormick & Bradshaw 2006 ). Many endocrine genes, including hormones and activating enzymes, have been identified in teleost
ZBSA – Freiburg Center for Systems Biology, University of Freiburg, Germany
Renal Division, University Hospital Freiburg, Germany
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ZBSA – Freiburg Center for Systems Biology, University of Freiburg, Germany
Renal Division, University Hospital Freiburg, Germany
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ZBSA – Freiburg Center for Systems Biology, University of Freiburg, Germany
Renal Division, University Hospital Freiburg, Germany
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Introduction The soil nematode C. elegans provides a very attractive model to study the genetics and biochemistry of the endocrine system, and provides insight on signaling pathways relevant for human biology and medicine. The worm
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Neonatology Division, Department of Pharmacological and Biomolecular Sciences, Department of Pathology, Department of Surgical and Morphological Sciences, Diabetes Division, Institute of Clinical Physiology, Texas Biomedical Research Institute, Department of Pediatrics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC-7812, San Antonio, Texas 78229, USA
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Neonatology Division, Department of Pharmacological and Biomolecular Sciences, Department of Pathology, Department of Surgical and Morphological Sciences, Diabetes Division, Institute of Clinical Physiology, Texas Biomedical Research Institute, Department of Pediatrics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC-7812, San Antonio, Texas 78229, USA
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Neonatology Division, Department of Pharmacological and Biomolecular Sciences, Department of Pathology, Department of Surgical and Morphological Sciences, Diabetes Division, Institute of Clinical Physiology, Texas Biomedical Research Institute, Department of Pediatrics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC-7812, San Antonio, Texas 78229, USA
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Neonatology Division, Department of Pharmacological and Biomolecular Sciences, Department of Pathology, Department of Surgical and Morphological Sciences, Diabetes Division, Institute of Clinical Physiology, Texas Biomedical Research Institute, Department of Pediatrics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC-7812, San Antonio, Texas 78229, USA
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et al . 2009 , Collombat et al . 2010 , Halban et al . 2010 ). In order to design therapies with this goal in mind, it is imperative to elucidate the natural development of the endocrine pancreas during fetal life. Pancreas morphogenesis has been
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To many attending the 6th Joint Meeting of British Endocrine Societies at the University of Warwick in March 1987, one symposium appeared perhaps somewhat unorthodox in its subject area, being juxtaposed alongside more clearly defined specialities such as the Oestrogen Receptor, Calcium-Regulating Hormones and Adrenal Gland. The Symposium itself (Journal of Endocrinology, 1987) covered a broad spectrum of endocrinology and gave refreshing views of contemporary endocrinology. These included:
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(1) a discussion of current morphological methods for identifying hormones and their receptors;
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(2) a critical analysis of so-called ectopic hormones;
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(3) a provocative hypothesis regarding the evolutionary origin of the neuroendocrine system;
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(4) the current status and likely direction of investigation into the, at present, unidentified endothelium-derived relaxing factor (EDRF).
All of these communications, dealing with rapidly moving areas, gave their audience insight into some philosophies that underly much of contemporary endocrinology. It is apt to preface a commentary on this Symposium by