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J-W Jeong Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA

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K Y Lee Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA

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J P Lydon Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA

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F J DeMayo Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA

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and 5′-flanking region for potential sequences that are recognized by PGR and estrogen receptor (ESR). Although no palindromic PRE (progesterone response element) could be identified in the 2 kb 5′-flanking region, this region contains one palindromic

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06747
Volume/Issue:
Volume 189: Issue 3
Free access
Yu-Chyu Chen Medical and Research Services, WJB Dorn Veterans Medical Center, Columbia, South Carolina 29201, USA
Department of Medicine, Medical Library Building, Suite 316, School of Medicine, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

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Madan L Nagpal Medical and Research Services, WJB Dorn Veterans Medical Center, Columbia, South Carolina 29201, USA
Department of Medicine, Medical Library Building, Suite 316, School of Medicine, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

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Douglas M Stocco Medical and Research Services, WJB Dorn Veterans Medical Center, Columbia, South Carolina 29201, USA
Department of Medicine, Medical Library Building, Suite 316, School of Medicine, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

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Tu Lin Medical and Research Services, WJB Dorn Veterans Medical Center, Columbia, South Carolina 29201, USA
Department of Medicine, Medical Library Building, Suite 316, School of Medicine, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

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Introduction Converging lines of evidence suggested that estrogen acts as an important paracrine factor to modulate testicular functions ( O’Donnell et al. 2001 ). Estrogen receptor (ER)α is present in the Leydig cells and ERβ is

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0087
Volume/Issue:
Volume 192: Issue 3
Free access
Maria Konstandi Department of Pharmacology, University of Ioannina, School of Health Sciences, Faculty of Medicine, Ioannina, Greece
National Institutes of Health, National Cancer Institute, Laboratory of Metabolism, Bethesda, Maryland, USA

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Christina E Andriopoulou Department of Pharmacology, University of Ioannina, School of Health Sciences, Faculty of Medicine, Ioannina, Greece

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Jie Cheng National Institutes of Health, National Cancer Institute, Laboratory of Metabolism, Bethesda, Maryland, USA

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Frank J Gonzalez National Institutes of Health, National Cancer Institute, Laboratory of Metabolism, Bethesda, Maryland, USA

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investigate the role of estrogens and progesterone in CYP2D regulation. The fluctuation of 17β-estradiol (E2) and progesterone circulating levels during the reproductive cycle is well documented. These female steroid hormones are synthesized and released by

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0561
Volume/Issue:
Volume 245: Issue 2
Restricted access
Jianmei Yang Department of Pediatric Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
Endocrinology, SBMS, Faculty of Medicine, The University of Queensland, St Lucia, Qld, Australia

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Chen Chen Endocrinology, SBMS, Faculty of Medicine, The University of Queensland, St Lucia, Qld, Australia

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), growth hormone (GH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), the LH/FSH ratio, androgens, estrogen, progesterone, insulin, ghrelin, leap2, asprosin, subfatin, etc. IR and hyperinsulinemia IR refers to the reduced sensitivity of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0342
Volume/Issue:
Volume 261: Issue 1
Restricted access
A Makker Division of Endocrinology, Central Drug Research Institute, Lucknow-226 001, India
Division of Parasitology, Central Drug Research Institute, Lucknow, India

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F W Bansode Division of Endocrinology, Central Drug Research Institute, Lucknow-226 001, India
Division of Parasitology, Central Drug Research Institute, Lucknow, India

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V M L Srivastava Division of Endocrinology, Central Drug Research Institute, Lucknow-226 001, India
Division of Parasitology, Central Drug Research Institute, Lucknow, India

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M M Singh Division of Endocrinology, Central Drug Research Institute, Lucknow-226 001, India
Division of Parasitology, Central Drug Research Institute, Lucknow, India

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from exogenous administration of H 2 O 2 ( Newton et al. 1999 ). A decrease in Cu,Zn SOD expression and activity has been observed in human endometrial stromal cells in vitro following withdrawal of estrogen and progesterone leading to generation

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06324
Volume/Issue:
Volume 188: Issue 1
Free access
Juana Enríquez Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición S. Zubirán (INCMNSZ), Mexico City 14000, Mexico
Department of Reproductive Biology, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico
Institute of Biomedical Research,
School of Dentistry and
School of Chemistry, Universidad Nacional Autónoma de Mexico (UNAM), Mexico City 04510, Mexico
Department of Nephrology and Mineral Metabolism, INCMNSZ, Mexico City, Mexico
National Institute of Perinatology and School of Medicine, UNAM/Hospital General de México, Montes Urales No. 800, Col. Lomas Virreyes, Mexico, D.F., C.P. 11000, Mexico City, Mexico

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Ana Elena Lemus Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición S. Zubirán (INCMNSZ), Mexico City 14000, Mexico
Department of Reproductive Biology, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico
Institute of Biomedical Research,
School of Dentistry and
School of Chemistry, Universidad Nacional Autónoma de Mexico (UNAM), Mexico City 04510, Mexico
Department of Nephrology and Mineral Metabolism, INCMNSZ, Mexico City, Mexico
National Institute of Perinatology and School of Medicine, UNAM/Hospital General de México, Montes Urales No. 800, Col. Lomas Virreyes, Mexico, D.F., C.P. 11000, Mexico City, Mexico

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Jesús Chimal-Monroy Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición S. Zubirán (INCMNSZ), Mexico City 14000, Mexico
Department of Reproductive Biology, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico
Institute of Biomedical Research,
School of Dentistry and
School of Chemistry, Universidad Nacional Autónoma de Mexico (UNAM), Mexico City 04510, Mexico
Department of Nephrology and Mineral Metabolism, INCMNSZ, Mexico City, Mexico
National Institute of Perinatology and School of Medicine, UNAM/Hospital General de México, Montes Urales No. 800, Col. Lomas Virreyes, Mexico, D.F., C.P. 11000, Mexico City, Mexico

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Higinio Arzate Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición S. Zubirán (INCMNSZ), Mexico City 14000, Mexico
Department of Reproductive Biology, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico
Institute of Biomedical Research,
School of Dentistry and
School of Chemistry, Universidad Nacional Autónoma de Mexico (UNAM), Mexico City 04510, Mexico
Department of Nephrology and Mineral Metabolism, INCMNSZ, Mexico City, Mexico
National Institute of Perinatology and School of Medicine, UNAM/Hospital General de México, Montes Urales No. 800, Col. Lomas Virreyes, Mexico, D.F., C.P. 11000, Mexico City, Mexico

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Gustavo A García Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición S. Zubirán (INCMNSZ), Mexico City 14000, Mexico
Department of Reproductive Biology, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico
Institute of Biomedical Research,
School of Dentistry and
School of Chemistry, Universidad Nacional Autónoma de Mexico (UNAM), Mexico City 04510, Mexico
Department of Nephrology and Mineral Metabolism, INCMNSZ, Mexico City, Mexico
National Institute of Perinatology and School of Medicine, UNAM/Hospital General de México, Montes Urales No. 800, Col. Lomas Virreyes, Mexico, D.F., C.P. 11000, Mexico City, Mexico

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Bertha Herrero Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición S. Zubirán (INCMNSZ), Mexico City 14000, Mexico
Department of Reproductive Biology, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico
Institute of Biomedical Research,
School of Dentistry and
School of Chemistry, Universidad Nacional Autónoma de Mexico (UNAM), Mexico City 04510, Mexico
Department of Nephrology and Mineral Metabolism, INCMNSZ, Mexico City, Mexico
National Institute of Perinatology and School of Medicine, UNAM/Hospital General de México, Montes Urales No. 800, Col. Lomas Virreyes, Mexico, D.F., C.P. 11000, Mexico City, Mexico

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Fernando Larrea Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición S. Zubirán (INCMNSZ), Mexico City 14000, Mexico
Department of Reproductive Biology, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico
Institute of Biomedical Research,
School of Dentistry and
School of Chemistry, Universidad Nacional Autónoma de Mexico (UNAM), Mexico City 04510, Mexico
Department of Nephrology and Mineral Metabolism, INCMNSZ, Mexico City, Mexico
National Institute of Perinatology and School of Medicine, UNAM/Hospital General de México, Montes Urales No. 800, Col. Lomas Virreyes, Mexico, D.F., C.P. 11000, Mexico City, Mexico

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Gregorio Pérez-Palacios Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición S. Zubirán (INCMNSZ), Mexico City 14000, Mexico
Department of Reproductive Biology, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico
Institute of Biomedical Research,
School of Dentistry and
School of Chemistry, Universidad Nacional Autónoma de Mexico (UNAM), Mexico City 04510, Mexico
Department of Nephrology and Mineral Metabolism, INCMNSZ, Mexico City, Mexico
National Institute of Perinatology and School of Medicine, UNAM/Hospital General de México, Montes Urales No. 800, Col. Lomas Virreyes, Mexico, D.F., C.P. 11000, Mexico City, Mexico

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, differentiation, and mineralization in the process of bone formation ( Qu et al. 1998 , Riggs et al. 2002 ). Even though osteoblastic cells posses the two isoforms of the estrogen-dependent nuclear progesterone receptor (PR) ( Rickard et al. 2002 ), the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0038
Volume/Issue:
Volume 193: Issue 3
Free access
Madhusmita Misra BUL 457, Pediatric Endocrine Unit, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
BUL 457, Pediatric Endocrine Unit, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA

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Anne Klibanski BUL 457, Pediatric Endocrine Unit, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA

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controlled trial (RCT) that physiological estrogen replacement as transdermal 17β-E 2 , which is not IGF1 suppressive, with cyclic progesterone, increases bone accrual rates at the spine and hip in adolescents with AN to approximate rates in normal

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0039
Volume/Issue:
Volume 221: Issue 3
Free access
Ying Chen Department of Biology, Syracuse University, 107 College Place, Syracuse, New York 13244, USA

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Kelsey Breen Department of Biology, Syracuse University, 107 College Place, Syracuse, New York 13244, USA

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Melissa E Pepling Department of Biology, Syracuse University, 107 College Place, Syracuse, New York 13244, USA

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primordial follicle assembly. In our previous research, we have shown that neonatal treatment with genistein, E 2 , or progesterone inhibits cyst breakdown and primordial follicle formation ( Chen et al . 2007 ). Our working model is that maternal estrogen

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0109
Volume/Issue:
Volume 202: Issue 3
Free access
Martha Lappas Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, 3002 Victoria, Australia

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Kirin Yee Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, 3002 Victoria, Australia

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Michael Permezel Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, 3002 Victoria, Australia

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Gregory E Rice Department of Obstetrics and Gynaecology, University of Melbourne and Mercy Perinatal Research Centre, Mercy Hospital for Women, 126 Clarendon Street, East Melbourne, 3002 Victoria, Australia

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, progesterone, dexamethasone and estrogen) and phorbol myristate acetate (PMA) induction on leptin, resistin and adiponectin release from placenta and fetal membranes (amnion and choriodecidua), and maternal subcutaneous adipose tissue and skeletal muscle tissue

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06227
Volume/Issue:
Volume 186: Issue 3
Free access
Geoffrey L Hammond Departments of Cellular & Physiological Sciences and Obstetrics & Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada

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aldosterone, which is bound primarily by albumin, other steroid hormones bind to CBG and SHBG with high (nM) affinity and specificity, with SHBG binding the major androgens and estrogens, and CBG binding the glucocorticoids and progesterone, preferentially

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0070
Volume/Issue:
Volume 230: Issue 1
Open access