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Jie Wei Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Xia Sun Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Yajie Chen Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Yuanyuan Li
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Liqiong Song
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Zhao Zhou
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Bing Xu
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Yi Lin Key Laboratory of Environment and Health, Key Laboratory of Urban Environment and Health, Department of Basic Medical Sciences, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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Shunqing Xu
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offspring of rats exposed to BPA fed on a HFD compared with controls fed on a HFD. Figure 2 The effect of BPA on hepatic energy metabolism in the liver. (A) mRNA expression of genes associated with lipogenesis, fatty acid oxidation, and gluconeogenesis. (B

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0356
Volume/Issue:
Volume 222: Issue 3
Free access
Sung-Soo Park Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju, South Korea

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Yeon-Joo Lee Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju, South Korea

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Sooyeon Song Division of Animal Science, College of Agriculture & Life Science, Chonnam National University, Gwangju, South Korea

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Boyong Kim Gwangju Center, Korea Basic Science Institute, Gwangju, South Korea

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Hyuno Kang Gwangju Center, Korea Basic Science Institute, Gwangju, South Korea

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Sejong Oh Division of Animal Science, College of Agriculture & Life Science, Chonnam National University, Gwangju, South Korea

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Eungseok Kim Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju, South Korea

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unexplored. The liver plays a key role in whole-body energy homeostasis by regulating lipogenesis and fatty acid oxidation ( Reddy & Rao 2006 ). A large body of evidence has shown that two transcription factors, sterol regulatory element-binding protein 1c

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0592
Volume/Issue:
Volume 237: Issue 2
Free access
Pongpan Tanajak Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine
Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine

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Siriporn C Chattipakorn Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine
Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine
Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine

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Nipon Chattipakorn Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine
Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine
Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine

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level ( Nishimura et al . 2000 ) and fatty acid β oxidation (FAO) which is the primary energy source for the myocardium ( Vega et al . 2000 , Planavila et al . 2013 ). Under stress conditions, FGF21 has been shown to reduce the apoptosis of Islet β

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0289
Volume/Issue:
Volume 227: Issue 2
Free access
Liisa Ailanen Institute of Biomedicine and Turku Center for Disease Modelling; Drug Research Doctoral Program, University of Turku, Turku, Finland

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Suvi T Ruohonen Institute of Biomedicine and Turku Center for Disease Modelling, University of Turku, Turku, Finland

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Laura H Vähätalo Institute of Biomedicine and Turku Center for Disease Modelling, University of Turku, Turku, Finland

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Katja Tuomainen Institute of Biomedicine and Turku Center for Disease Modelling, University of Turku, Turku, Finland

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Kim Eerola Institute of Biomedicine and Turku Center for Disease Modelling, University of Turku, Turku, Finland

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Henriikka Salomäki-Myftari Institute of Biomedicine and Turku Center for Disease Modelling; Drug Research Doctoral Program, University of Turku, Turku, Finland

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Matias Röyttä Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland

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Asta Laiho Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

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Markku Ahotupa Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

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Helena Gylling Department of Internal Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

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Eriika Savontaus Institute of Biomedicine and Turku Center for Disease Modelling, University of Turku; Turku University Hospital, Unit of Clinical Pharmacology, Turku, Finland

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contribute to hepatic lipogenesis, VLDL-triglyceride (TG) and VLDL-cholesterol secretion, fatty acid (FA) oxidation and increased serum cholesterol levels (Zarjevski et al. 1993, Stafford et al. 2008, Zhang et al. 2010, Bruinstroop et al. 2012, Xie

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0223
Volume/Issue:
Volume 234: Issue 1
Free access
Prasanthi P Koganti Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA

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Vimal Selvaraj Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA

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status between the mouse and hamster adrenals, we evaluated the expression of a few core genes involved in the regulation of these processes. We found that Cpt1a , a transferase essential for mitochondrial fatty acid oxidation (FAO), was substantially

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0189
Volume/Issue:
Volume 247: Issue 1
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William WN Jr
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RB Ceddia
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R Curi
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Leptin directly increases the rate of exogenous glucose and fatty acids oxidation in isolated adipocytes. However, the effects of leptin on fatty acid metabolism in white adipose tIssue have not been examined in detail. Here, we report that in adipocytes incubated for 6 h in the presence of leptin (10 ng/ml), the insulin-stimulated de novo fatty acid synthesis was inhibited by 36% (P<0.05), while the exogenous oxidation of acetic and oleic acids was increased by 50% and 76% respectively. Interestingly, leptin did not alter the oxidation of intracellular fatty acids. Leptin-incubated cells presented a 16-fold increase in the incorporation of oleic acid into triglyceride (TG) and a 123% increase in the intracellular TG hydrolysis (as measured by free fatty acids release). Fatty acid-TG cycling was not affected by leptin. By employing fatty acids radiolabeled with (3)H and (14)C, we could determine the concomitant influx of fatty acids (incorporation of fatty acids into TG) and efflux of fatty acids (intracellular fatty acids oxidation and free fatty acids release) in the incubated cells. Leptin increased by 30% the net efflux of fatty acids from adipocytes. We conclude that leptin directly inhibits de novo synthesis of fatty acids and increases the release and oxidation of fatty acids in isolated rat adipocytes. These direct energy-dissipating effects of leptin may play an important role in reducing accumulation of fatty acids into TG of rat adipose cells.

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.0.1750735
Volume/Issue:
Volume 175: Issue 3
Free access
Guangcui Xu School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China

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Tingting Yan School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China

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Qiang Peng School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China

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Haibin Li School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China

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Weidong Wu School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China

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Xianwen Yi Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA

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Yingzheng Zhao School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China

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an enzyme present in the outer mitochondria membrane that regulates β-oxidation by transferring long-chain fatty acids into the mitochondria ( Schreurs et al. 2010 ). Therefore, we postulated that the anti-adipogenic effect of LA was partially

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0606
Volume/Issue:
Volume 248: Issue 2
Restricted access
Cristina Mora Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Cristina Pintado Biochemistry, Faculty of Environmental Sciences and and CRIB, UCLM, Toledo, Spain

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Blanca Rubio Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Lorena Mazuecos Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Virginia López Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Alejandro Fernández Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Aurora Salamanca Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Brenda Bárcena Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Teresa Fernández-Agulló Health Sciences Faculty, University Rey Juan Carlos, Alcorcón, Madrid, Spain

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Carmen Arribas Biochemistry, Faculty of Environmental Sciences and and CRIB, UCLM, Toledo, Spain

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Nilda Gallardo Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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Antonio Andrés Biochemistry, Faculty of Science and Technological Chemistry, and Regional Centre for Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain

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-shortened fatty acids to the mitochondria for complete oxidation, was significantly higher in leptin compared with pair-fed rats ( Fig. 4B ). As a result, the contribution of peroxisomes to the complete plamitate oxidation was increased from 39% in pair-fed to 63

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0554
Volume/Issue:
Volume 236: Issue 1
Free access
Sandra Pereira Department of Physiology, Department of Medicine, Toronto General Research Institute, Banting and Best Diabetes Centre, Institute of Medical Science, School of Pharmacy, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Anu Shah Department of Physiology, Department of Medicine, Toronto General Research Institute, Banting and Best Diabetes Centre, Institute of Medical Science, School of Pharmacy, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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I George Fantus Department of Physiology, Department of Medicine, Toronto General Research Institute, Banting and Best Diabetes Centre, Institute of Medical Science, School of Pharmacy, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Department of Medicine, Toronto General Research Institute, Banting and Best Diabetes Centre, Institute of Medical Science, School of Pharmacy, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Department of Medicine, Toronto General Research Institute, Banting and Best Diabetes Centre, Institute of Medical Science, School of Pharmacy, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Department of Medicine, Toronto General Research Institute, Banting and Best Diabetes Centre, Institute of Medical Science, School of Pharmacy, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Department of Medicine, Toronto General Research Institute, Banting and Best Diabetes Centre, Institute of Medical Science, School of Pharmacy, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Jamie W Joseph Department of Physiology, Department of Medicine, Toronto General Research Institute, Banting and Best Diabetes Centre, Institute of Medical Science, School of Pharmacy, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Adria Giacca Department of Physiology, Department of Medicine, Toronto General Research Institute, Banting and Best Diabetes Centre, Institute of Medical Science, School of Pharmacy, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Department of Medicine, Toronto General Research Institute, Banting and Best Diabetes Centre, Institute of Medical Science, School of Pharmacy, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Department of Medicine, Toronto General Research Institute, Banting and Best Diabetes Centre, Institute of Medical Science, School of Pharmacy, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, Department of Medicine, Toronto General Research Institute, Banting and Best Diabetes Centre, Institute of Medical Science, School of Pharmacy, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8

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Introduction Obesity is associated with elevated circulating free fatty acids (FFAs) and FFAs cause insulin resistance ( Lewis et al . 2002 , Xiao et al . 2008 ). FFAs induce oxidative stress ( Nakamura et al . 2009 , Yuzefovych et al . 2010

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0676
Volume/Issue:
Volume 225: Issue 1
Free access
Melanie Tran Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Golam Mostofa Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Michael Picard Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Jianguo Wu Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Li Wang Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA

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Dong-Ju Shin Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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timepoints 0, 5, 10, 15, 30, and 60 min after the 6 h fasting period, then cell lysates were collected for immunoblotting analyses. Biochemical analysis Fatty acid oxidation (FAO) enzyme activity was measured in livers of HFHS-fed mice using a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0073
Volume/Issue:
Volume 256: Issue 3
Restricted access