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Xiaoning Li College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai, China

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Junhua Xiao College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai, China

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Yating Fan College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai, China

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Kan Yang College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai, China

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Kai Li College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai, China

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Xin Wang College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai, China

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Yanhua Lu State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China

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Yuxun Zhou College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai, China
Human Phenome Institute, Fudan University, Shanghai, China

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role in regulating the puberty onset of female mice ( Zhou et al. 2018 ). miR-29 family (miR-29s) consists of four members: miR-29a, miR-29b1, miR-29b2 and miR-29c, which have been postulated to potentially regulate more than 4000 gene products. In

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J L Crawford Reproduction Group, AgResearch Ltd, Wallaceville Animal Research Centre, Ward Street, PO Box 40063, Upper Hutt, New Zealand

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B P Thomson Reproduction Group, AgResearch Ltd, Wallaceville Animal Research Centre, Ward Street, PO Box 40063, Upper Hutt, New Zealand

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M F Beaumont Reproduction Group, AgResearch Ltd, Wallaceville Animal Research Centre, Ward Street, PO Box 40063, Upper Hutt, New Zealand

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D C Eckery Reproduction Group, AgResearch Ltd, Wallaceville Animal Research Centre, Ward Street, PO Box 40063, Upper Hutt, New Zealand

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cyclic steroid hormone replacement on prolactin and luteinizing hormone surges in female rats. Reproduction 128 373 –378. Butcher RL , Fugo NW & Collins WE 1972 Semicircadian rhythm in plasma levels of prolactin during

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P Froment INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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F Gizard INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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D Defever INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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B Staels INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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J Dupont INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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P Monget INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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). The administration of phthalate esters to female rats leads to an increase in the length of the estrous cycle and dysovulation ( Davis et al. 1994 ). Limited experiments have shown that phthalate esters may interfere with reproduction by

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S E Ulbrich Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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S Rehfeld Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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S Bauersachs Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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E Wolf Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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R Rottmayer Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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S Hiendleder Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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M Vermehren Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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F Sinowatz Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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H H D Meyer Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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R Einspanier Physiology-Weihenstephan, Technical University of Munich, Alles Hörsaalgebäude, 85350 Freising, Germany
Institute of Veterinary Biochemistry, Free University of Berlin, Oertzenweg 19b, D-14163 Berlin, Germany
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre of the Ludwig-Maximilians-University Munich, Munich, Germany
Institute of Veterinary Anatomy, Histology and Embryology, Ludwig-Maximilians-University Munich, Veterinaerstr. 13, 80539 Munich, Germany

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growth factor (FGF) family members during the final growth of bovine ovarian follicles. Molecular Reproduction and Development 67 162 –171. Bryant CE , Tomlinson A, Mitchell JA, Thiemermann C & Willoughby DA 1995 Nitric

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M S Fernandes Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany

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V Pierron Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany

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D Michalovich Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany

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S Astle Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany

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S Thornton Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany

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H Peltoketo Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany

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E W-F Lam Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany

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B Gellersen Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany

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I Huhtaniemi Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany

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J Allen Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany

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J J Brosens Institute of Reproductive and Developmental Biology, Wolfson & Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany

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Introduction Progesterone is required for all aspects of female reproductive function, including sexual behaviour, gonadotrophin secretion, ovulation, blastocyst implantation and maintenance of pregnancy ( Mulac-Jericevic et al

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Jie Gong College of Ocean and Earth Sciences, Collaborative Innovation Center for Development and Utilization of Marine Biological Resources, College of Marine and Environmental Sciences, Xiamen University, Xiamen 361102, China

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Haihui Ye College of Ocean and Earth Sciences, Collaborative Innovation Center for Development and Utilization of Marine Biological Resources, College of Marine and Environmental Sciences, Xiamen University, Xiamen 361102, China
College of Ocean and Earth Sciences, Collaborative Innovation Center for Development and Utilization of Marine Biological Resources, College of Marine and Environmental Sciences, Xiamen University, Xiamen 361102, China

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Yinjie Xie College of Ocean and Earth Sciences, Collaborative Innovation Center for Development and Utilization of Marine Biological Resources, College of Marine and Environmental Sciences, Xiamen University, Xiamen 361102, China

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Yanan Yang College of Ocean and Earth Sciences, Collaborative Innovation Center for Development and Utilization of Marine Biological Resources, College of Marine and Environmental Sciences, Xiamen University, Xiamen 361102, China

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Huiyang Huang College of Ocean and Earth Sciences, Collaborative Innovation Center for Development and Utilization of Marine Biological Resources, College of Marine and Environmental Sciences, Xiamen University, Xiamen 361102, China

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Shaojing Li College of Ocean and Earth Sciences, Collaborative Innovation Center for Development and Utilization of Marine Biological Resources, College of Marine and Environmental Sciences, Xiamen University, Xiamen 361102, China

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Chaoshu Zeng College of Ocean and Earth Sciences, Collaborative Innovation Center for Development and Utilization of Marine Biological Resources, College of Marine and Environmental Sciences, Xiamen University, Xiamen 361102, China
College of Ocean and Earth Sciences, Collaborative Innovation Center for Development and Utilization of Marine Biological Resources, College of Marine and Environmental Sciences, Xiamen University, Xiamen 361102, China

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might be involved in the feedback regulation of MIH secretion. In crustaceans, the ecdysone signaling pathway is also known to involve in the regulation of female reproduction ( Subramoniam 2000 ). During ovarian maturation of crustaceans, high levels of

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Karine Reynaud
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Sylvie Chastant-Maillard
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Séverine Batard
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Sandra Thoumire
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Philippe Monget UMR 1198 INRA/ENVA Biologie du Développement et Reproduction, Physiologie de la Reproduction et des Comportements, Alfort Veterinary School, 7 Avenue du Général de Gaulle, 94704 Maisons-Alfort Cedex, France

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several parameters of female reproduction such as fertility, ovulation rate and size of preovulatory follicles. The first evidence comes from mice knocked-out for the GH receptor ( Bachelot et al . 2002 ), and transgenic female mice overexpressing IGFBP1

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Eric W-F Lam Cancer Research-UK Laboratories, Institute of Reproductive and Developmental Biology, Division of Cancer and

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Kunal Shah Cancer Research-UK Laboratories, Institute of Reproductive and Developmental Biology, Division of Cancer and

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Jan J Brosens Cancer Research-UK Laboratories, Institute of Reproductive and Developmental Biology, Division of Cancer and

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recruitment of FOXO1 to the decidual PRL promoter converts HOXA11, a transcription factor essential for development and function of the female reproductive tract, from a repressor to a strong activator of gene expression ( Lynch et al . 2009 ). These

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Tong Sun College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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Wen-Bo Deng College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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Hong-Lu Diao College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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Hua Ni College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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Yu-Yan Bai College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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Xing-Hong Ma College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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Li-Bin Xu College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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Zeng-Ming Yang College of Life Sciences, Northeast Agricultural University, Harbin 150030, China

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and fertilization processes ( Challis 1997 , Hizaki et al. 1999 , Sugimoto et al. 2000 ). Although PGE2 is essential for female reproduction, PGES expression and regulation in the mouse during female reproduction had not been

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Rob Zachow
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Mehmet Uzumcu Department of Physiology and Biophysics, Department of Animal Sciences, Robert Wood Johnson Medical School-UMDNJ, 675 Hoes Lane West, Piscataway, New Jersey 08854, USA

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for the process of folliculogenesis ( Burns & Matzuk 2002 , Roy & Matzuk 2006 ). The HGF system and folliculogenesis During the female reproductive lifespan, follicles are recruited from a latent resting pool of primordial follicles into a growing

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