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Guillermo García-Eguren Group of Endocrine Disorders, IDIBAPS, Barcelona, Spain

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Oriol Giró Group of Endocrine Disorders, IDIBAPS, Barcelona, Spain

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María del Mar Romero Department of Biochemistry and Molecular Biomedicine, Section of Nutrition, Faculty of Biology, University of Barcelona, Barcelona, Spain
Institute of Biomedicine, University of Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Obesidad y Nutrición (CIBEROBN), Carlos III Health Institute, Madrid, Spain

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Mar Grasa Department of Biochemistry and Molecular Biomedicine, Section of Nutrition, Faculty of Biology, University of Barcelona, Barcelona, Spain
Institute of Biomedicine, University of Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Obesidad y Nutrición (CIBEROBN), Carlos III Health Institute, Madrid, Spain

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Felicia A Hanzu Group of Endocrine Disorders, IDIBAPS, Barcelona, Spain
Department of Endocrinology and Nutrition, Hospital Clinic of Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Carlos III Health Institute, Madrid, Spain
Department of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain

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Introduction Chronic exposure to excess glucocorticoid (GC) levels, resulting from either endogenous Cushing’s syndrome (CS) or exogenous GC therapy, causes several adverse outcomes, including obesity, insulin resistance, dyslipidemia

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0168
Volume/Issue:
Volume 242: Issue 2
Free access
Andrea Lovdel University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Karla J Suchacki University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Fiona Roberts University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Richard J Sulston University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Robert J Wallace Department of Orthopaedics, The University of Edinburgh, Edinburgh, UK

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Benjamin J Thomas University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Rachel M B Bell University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Iris Pruñonosa Cervera University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Gavin J Macpherson Department of Orthopaedic Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK

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Nicholas M Morton University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK

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Natalie Z M Homer University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Karen E Chapman University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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William P Cawthorn University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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) ( Bravenboer et al. 2020 , Cawthorn 2020 ). Bone marrow adipocytes further accumulate in diverse conditions, including ageing, obesity, type 2 diabetes, osteoporosis, chronic kidney disease, and in iatrogenic contexts such as chronic glucocorticoid treatment

Article Type:
Research Article
Collections:
Sex effects collection
DOI:
https://doi.org/10.1530/JOE-24-0072
Volume/Issue:
Volume 262: Issue 2
Open access
Ljupka Gligorovska Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Biljana Bursać Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Sanja Kovačević Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Nataša Veličković Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Gordana Matić Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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Ana Djordjevic Department of Biochemistry, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia

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reporting that Mif - knockout mice display improved insulin sensitivity and glucose tolerance ( Verschuren et al. 2009 , Kleemann & Bucala 2010 ). Although MIF synthesis and secretion are upregulated by the glucocorticoid hormones (GCs), MIF acts as

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0333
Volume/Issue:
Volume 240: Issue 2
Free access
Stuart A Morgan Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK
Department of Biosciences, Nottingham Trent University, Nottingham, UK

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Laura L Gathercole Department of Biological & Medical Sciences, Oxford Brooks University, Oxford, UK

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Zaki K Hassan-Smith Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK

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Jeremy Tomlinson Radcliffe Department of Medicine, University of Oxford, Oxford, UK

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Paul M Stewart Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK
NEXUS, Discovery Way, University of Leeds, Leeds, UK

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Gareth G Lavery Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK
Department of Biosciences, Nottingham Trent University, Nottingham, UK

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improve healthspan. Interestingly, the aged phenotype shares several metabolic similarities with that of circulatory glucocorticoid (GC) excess (Cushing’s syndrome), including insulin resistance, type 2 diabetes mellitus, central obesity, hypertension

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0169
Volume/Issue:
Volume 255: Issue 3
Open access
O Schakman Unité de Diabétologie et Nutrition, Faculté de Médecine, Université Catholique de Louvain, 54 Avenue Hippocrate, B-1200 Brussels, Belgium

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H Gilson Unité de Diabétologie et Nutrition, Faculté de Médecine, Université Catholique de Louvain, 54 Avenue Hippocrate, B-1200 Brussels, Belgium

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J P Thissen Unité de Diabétologie et Nutrition, Faculté de Médecine, Université Catholique de Louvain, 54 Avenue Hippocrate, B-1200 Brussels, Belgium

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Introduction The catabolic effects of glucocorticoids have been well known for many years. Either as drugs used to treat several medical conditions or as endocrine hormones released in response to many stress situations, glucocorticoids may cause

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0606
Volume/Issue:
Volume 197: Issue 1
Free access
Thomas Dickmeis Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen, Germany

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hypothalamus ( Fig. 2 ; Buijs & Kalsbeek 2001 , Kalsbeek & Buijs 2002 , Saper et al . 2005 ), and may underlie the circadian changes observed in processes governed by these structures. Figure 2 Neural pathways in circadian control of glucocorticoid release

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0415
Volume/Issue:
Volume 200: Issue 1
Free access
Rui Song Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA

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Xiang-Qun Hu Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA

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Lubo Zhang Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA

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Introduction Glucocorticoids are a class of corticosteroids and are chiefly produced in the zona fasciculata of the adrenal cortex. These steroid hormones are crucial endocrine regulators of body functions in homeostasis and adaptation to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0672
Volume/Issue:
Volume 242: Issue 1
Free access
Alistair I Freeman
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Helen L Munn
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Val Lyons
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Alexander Dammermann
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Jonathan R Seckl
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Karen E Chapman
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Introduction Glucocorticoids exert effects on virtually all tissues, the majority of which are mediated by the type II glucocorticoid receptor (GR). Despite near ubiquitous expression, GR levels vary widely both between and within

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05773
Volume/Issue:
Volume 183: Issue 2
Free access
Ellen H Stolte Department of Animal Physiology, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG, Wageningen, The Netherlands

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B M Lidy Verburg van Kemenade Department of Animal Physiology, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG, Wageningen, The Netherlands

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Huub F J Savelkoul Department of Animal Physiology, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG, Wageningen, The Netherlands

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Gert Flik Department of Animal Physiology, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG, Wageningen, The Netherlands

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Introduction Glucocorticoids (GCs; cortisol and corticosterone) play a pivotal role in vertebrate physiology through a plethora of control mechanisms. The GC system, with a nuclear glucocorticoid receptor (GR), is found in all

Article Type:
Review Article
DOI:
https://doi.org/10.1677/joe.1.06703
Volume/Issue:
Volume 190: Issue 1
Free access
Geoffrey L Hammond Departments of Cellular & Physiological Sciences and Obstetrics & Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada

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aldosterone, which is bound primarily by albumin, other steroid hormones bind to CBG and SHBG with high (nM) affinity and specificity, with SHBG binding the major androgens and estrogens, and CBG binding the glucocorticoids and progesterone, preferentially

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0070
Volume/Issue:
Volume 230: Issue 1
Open access