as a regulator involved in glucose metabolism. Results of early studies carried out of patients with end-stage renal disease (ESRD) indicated that EPO not only treated anemia but also improved insulin sensitivity ( Borissova et al . 1993 , Mak 1996
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Corinne Caillaud, Mie Mechta, Heidi Ainge, Andreas N Madsen, Patricia Ruell, Emilie Mas, Catherine Bisbal, Jacques Mercier, Stephen Twigg, Trevor A Mori, David Simar, and Romain Barrès
Holly M Johnson, Erin Stanfield, Grace J Campbell, Erica E Eberl, Gregory J Cooney, and Kim S Bell-Anderson
insulin action. However, little is currently known about how specific nutrients regulate insulin sensitivity acutely. We previously reported that substituting one high-glucose meal for the usual high-fat meal in high-fat-fed rats restored insulin
Guillermo Vazquez-Anaya, Bridget Martinez, José G Soñanez-Organis, Daisuke Nakano, Akira Nishiyama, and Rudy M Ortiz
genes, THs have critical roles in the maintenance of glucose homeostasis ( Chidakel et al. 2005 , Villicev et al. 2007 , Brenta 2010 ). However, evidence suggests that TH may induce non-genomic effects that contribute to cellular metabolism
Ishita Bakshi, Eurwin Suryana, Lewin Small, Lake-Ee Quek, Amanda E Brandon, Nigel Turner, and Gregory J Cooney
provide energy for contraction at rates that vastly exceed the synthesis of new glucose and glycogen from lactate or other 3 carbon precursors via gluconeogenesis. This predominance of glycolytic over gluconeogenic pathways in muscle is largely governed by
Gustavo Canul-Medina, Leticia Riverón-Negrete, Karina Pastén-Hidalgo, Paulina Morales-Castillo, Francisco García-Vázquez, and Cristina Fernandez-Mejia
Introduction Female physiology is modified during pregnancy and lactation to meet the nutritional demands of the fetus and the neonate. The increased glucose requirements of the developing infant require major adjustments in glucose
George Harb and Gregory S Korbutt
Introduction Pancreatic β-cells not only depend on glucose as a source of fuel, but also require it as a growth factor as well as for the regulation of glucokinase and insulin gene transcription ( Liang et al. 1992 , Chen et al
Olivier Dumortier, Gaia Fabris, Didier F Pisani, Virginie Casamento, Nadine Gautier, Charlotte Hinault, Patricia Lebrun, Christophe Duranton, Michel Tauc, Stéphane Dalle, Julie Kerr-Conte, François Pattou, Marc Prentki, and Emmanuel Van Obberghen
Introduction The main beta cell mission consists in its ability to secrete insulin for maintenance of organismal glucose homeostasis. This hallmark requires expression of a set of genes (allowed genes) and the concomitant repression of others
Lars P Klieverik, Ewout Foppen, Mariëtte T Ackermans, Mireille J Serlie, Hans P Sauerwein, Thomas S Scanlan, David K Grandy, Eric Fliers, and Andries Kalsbeek
hypothalamus, regulates most of the processes affected by thyronamines (body temperature, cardiac function, and energy metabolism). Moreover, a principal role in regulating hepatic glucose metabolism has recently emerged for the hypothalamus ( Obici et al
Barbara C Fam, Laura J Rose, Rebecca Sgambellone, Zheng Ruan, Joseph Proietto, and Sofianos Andrikopoulos
Introduction The inadequate response of the body to reduce high blood glucose levels can lead to the development of type 2 diabetes. This state of hyperglycaemia is contributed by three main defects: increased glucose production from the liver, a
Herbert A Schmid and Josef Brueggen
-acting release (LAR) in which pasireotide provided improvement in the symptoms of carcinoid syndrome and was associated with stabilization of tumor growth ( Kvols et al . 2010 ). Somatostatin analogs have also been found to have an effect on glucose homeostasis
