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Departments of Physiology and Pharmacology and
Cell and Developmental Biology, Oregon Health and Science University, 505 NW 185th Ave., Beaverton, OR 97006, USA
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Departments of Physiology and Pharmacology and
Cell and Developmental Biology, Oregon Health and Science University, 505 NW 185th Ave., Beaverton, OR 97006, USA
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Departments of Physiology and Pharmacology and
Cell and Developmental Biology, Oregon Health and Science University, 505 NW 185th Ave., Beaverton, OR 97006, USA
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Departments of Physiology and Pharmacology and
Cell and Developmental Biology, Oregon Health and Science University, 505 NW 185th Ave., Beaverton, OR 97006, USA
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dramatic effect on plasma membrane expression. Accordingly, these rodent receptors that interfere with human gonadotropin-releasing hormone receptor (GnRHR) plasma membrane expression frequently do not have any impact on rat or mouse GnRHR, since, although
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Introduction Gonadotropin-releasing hormone (GnRH) plays an important role in the control of vertebrate reproduction. Similarly, GnRH or GnRH-like peptides occur in some protochordate and invertebrate species ( Adams et al. 2003
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Department of Paediatric Endocrinology, Royal Hospital for Children, Glasgow, UK
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secretion of gonadal sex steroids (oestrogen and testosterone) ( Flanagan & Manilall 2017 ). This is achieved and regulated via the activation of the anterior pituitary gonadotropin-releasing hormone (GnRH) receptors via its decapeptide ligand. Consequently
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Unit of Experimental Therapeutics, Institute of Cancer Sciences, University of Glasgow Glasgow, UK
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Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
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2005 Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty . Journal of Neuroscience 25 11349 – 11356 . ( https://doi.org/10.1523/JNEUROSCI.3328-05.2005 ) 10.1523/JNEUROSCI.3328
Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, Wisconsin 53705, USA
Department of Biochemistry, Indian Institute of Science, Bangalore, India
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53706, USA
Voyager Pharmaceutical Corporation, Raleigh, North Carolina 27615, USA
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Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, Wisconsin 53705, USA
Department of Biochemistry, Indian Institute of Science, Bangalore, India
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53706, USA
Voyager Pharmaceutical Corporation, Raleigh, North Carolina 27615, USA
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Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, Wisconsin 53705, USA
Department of Biochemistry, Indian Institute of Science, Bangalore, India
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53706, USA
Voyager Pharmaceutical Corporation, Raleigh, North Carolina 27615, USA
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Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, Wisconsin 53705, USA
Department of Biochemistry, Indian Institute of Science, Bangalore, India
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53706, USA
Voyager Pharmaceutical Corporation, Raleigh, North Carolina 27615, USA
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Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, Wisconsin 53705, USA
Department of Biochemistry, Indian Institute of Science, Bangalore, India
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53706, USA
Voyager Pharmaceutical Corporation, Raleigh, North Carolina 27615, USA
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Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, Wisconsin 53705, USA
Department of Biochemistry, Indian Institute of Science, Bangalore, India
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53706, USA
Voyager Pharmaceutical Corporation, Raleigh, North Carolina 27615, USA
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Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, Wisconsin 53705, USA
Department of Biochemistry, Indian Institute of Science, Bangalore, India
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53706, USA
Voyager Pharmaceutical Corporation, Raleigh, North Carolina 27615, USA
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Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, Wisconsin 53705, USA
Department of Biochemistry, Indian Institute of Science, Bangalore, India
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53706, USA
Voyager Pharmaceutical Corporation, Raleigh, North Carolina 27615, USA
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Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, Wisconsin 53705, USA
Department of Biochemistry, Indian Institute of Science, Bangalore, India
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53706, USA
Voyager Pharmaceutical Corporation, Raleigh, North Carolina 27615, USA
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Introduction Luteinizing hormone (LH) is secreted from gonadotropes of the anterior pituitary into the bloodstream following pulsatile stimulation by hypothalamic gonadotropin-releasing hormone I (GnRH I; Larsen et al. 2002 ). LH
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e58159 . ( https://doi.org/10.3791/58159 ) Aizen J Kasuto H Golan M Zakay H Levavi-Sivan B 2007 Tilapia follicle-stimulating hormone (FSH): immunochemistry, stimulation by gonadotropin-releasing hormone, and effect of biologically
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Introduction The preovulatory surge of luteinizing hormone (LH) secretion in cyclic rats and the daily surge in ovariectomized, estrogen-treated rats are caused by the central action of estrogen on the gonadotropin-releasing hormone
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stimulatory effect on prolactin release are exerted in the hypothalamus as well as in the pituitary. Hence, both structures express ERα and ERβ. The release of the pituitary gonatrotropins is stimulated by hypothalamic gonadotropin-releasing hormone (GnRH), of
Frank H. Netter School of Medicine, Quinnipiac University, North Haven, Connecticut, USA
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Section of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA
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hypothalamus, IR is present in both the gonadotropin-releasing hormone (GnRH)-secreting neurons and kisspeptin neurons. The onset of puberty is marked by increased GnRH pulsatility, which in turn initiates signaling across the HPO axis ( DiVall & Radovick 2009
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Human Phenome Institute, Fudan University, Shanghai, China
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) axis, symbolized by the pulsatile release of gonadotropin-releasing hormone (GnRH) ( Ebling 2005 ). GnRH is a peptide hormone composed of ten amino acids (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) ( Lee et al. 2008 ) and represents the final