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A Corbould
A Corbould
Prince Henry’s Institute of Medical Research, Monash Medical Centre, Block E, Level 4, Clayton Road, Clayton, Victoria 3168, Australia
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Introduction Adipose tissue is now recognized to play a central role in determining whole body insulin sensitivity ( Minokoshi et al. 2003 ). In animal models, insulin resistance in adipose tissue secondarily results in insulin
Sergio Di Meo
Sergio Di Meo
Department of Biology, University of Naples ‘Federico II’, Naples, Italy
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Susanna Iossa
Susanna Iossa
Department of Biology, University of Naples ‘Federico II’, Naples, Italy
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Paola Venditti
Paola Venditti
Department of Biology, University of Naples ‘Federico II’, Naples, Italy
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Introduction In recent years, the observation that insulin resistance (IR) and type 2 diabetes mellitus (T2DM) are growing dramatically all over the world has stimulated the research on such metabolic disorders and their possible therapy. At
Sattar Gorgani-Firuzjaee
Sattar Gorgani-Firuzjaee
Department of Biochemistry, Department of Clinical Biochemistry, Endocrinology and Metabolism Research Centre, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
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Salar Bakhtiyari
Salar Bakhtiyari
Department of Biochemistry, Department of Clinical Biochemistry, Endocrinology and Metabolism Research Centre, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
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Abolfazl Golestani
Abolfazl Golestani
Department of Biochemistry, Department of Clinical Biochemistry, Endocrinology and Metabolism Research Centre, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
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Reza Meshkani
Reza Meshkani
Department of Biochemistry, Department of Clinical Biochemistry, Endocrinology and Metabolism Research Centre, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
Department of Biochemistry, Department of Clinical Biochemistry, Endocrinology and Metabolism Research Centre, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
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Department of Biochemistry, Department of Clinical Biochemistry, Endocrinology and Metabolism Research Centre, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
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Introduction Insulin resistance plays a major role in the development of some diseases such as type 2 diabetes (T2D) and metabolic syndrome ( Czech 2002 ). Resistance to the cellular actions of insulin causes reduced glucose uptake in muscle
Gary J Remington
Gary J Remington
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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Celine Teo
Celine Teo
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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Virginia Wilson
Virginia Wilson
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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Araba Chintoh
Araba Chintoh
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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Melanie Guenette
Melanie Guenette
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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Zohra Ahsan
Zohra Ahsan
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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Adria Giacca
Adria Giacca
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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Margaret K Hahn
Margaret K Hahn
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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point, to our knowledge, only two clinical studies exist specifically evaluating insulin resistance or impaired glucose tolerance respectively in the context of antipsychotic treatment ( Henderson et al . 2009 , Smith et al . 2013 ). Both examined
João Paulo G Camporez
João Paulo G Camporez
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Mohamed Asrih
Mohamed Asrih
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Dongyan Zhang
Dongyan Zhang
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Mario Kahn
Mario Kahn
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Varman T Samuel
Varman T Samuel
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Michael J Jurczak
Michael J Jurczak
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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François R Jornayvaz
François R Jornayvaz
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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, is affecting about one out of three individuals ( Williams et al . 2011 ). NAFLD is a major risk factor in the development of insulin resistance and type 2 diabetes ( Angulo 2002 , Fabbrini et al . 2010 , Asrih & Jornayvaz 2015 ). Fibroblast
J Ogino
J Ogino
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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K Sakurai
K Sakurai
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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K Yoshiwara
K Yoshiwara
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Yoichi Suzuki
Yoichi Suzuki
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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N Ishizuka
N Ishizuka
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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N Seki
N Seki
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Yoshifumi Suzuki
Yoshifumi Suzuki
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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H Koseki
H Koseki
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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T Shirasawa
T Shirasawa
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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N Hashimoto
N Hashimoto
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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K Yagui
K Yagui
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Y Saito
Y Saito
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Department of Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Department of Internal Medicine, Social Insurance Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi 273-8556, Japan
Department of Internal Medicine, Matsudo Municipal Hospital, 4005 Kamihongo, Matsudo 271-8511, Japan
Laboratory for Developmental Genetics, Riken Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Department of Diabetes and Metabolic Disease, Asahi General Hospital, I-1136, Asahi 289-2511, Japan
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Introduction Type-2 diabetes mellitus is a common metabolic disorder characterized by insulin resistance and deterioration of β-cell function ( Reaven 1988 , DeFronzo et al. 1992 ). Pancreatic β-cells showed various responses when
Yoshinori Kanemaru
Yoshinori Kanemaru
Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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Norio Harada
Norio Harada
Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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Satoko Shimazu-Kuwahara
Satoko Shimazu-Kuwahara
Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Preemptive Medicine and Lifestyle Related Disease Research Center, Kyoto University Hospital, Kyoto, Japan
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Preemptive Medicine and Lifestyle Related Disease Research Center, Kyoto University Hospital, Kyoto, Japan
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Shunsuke Yamane
Shunsuke Yamane
Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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Eri Ikeguchi
Eri Ikeguchi
Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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Yuki Murata
Yuki Murata
Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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Sakura Kiyobayashi
Sakura Kiyobayashi
Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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Tomonobu Hatoko
Tomonobu Hatoko
Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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Nobuya Inagaki
Nobuya Inagaki
Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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causes insulin resistance through inflammation ( Kalyani et al . 2014 ). This age-related change is called ‘sarcopenic obesity’, and is an important health issue in aging societies ( Prado et al . 2012 , Cleasy et al . 2016 ). Obesity is related to a
Jun Huang
Jun Huang
Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
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Rita Sharma
Rita Sharma
Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
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Sohana Siyar
Sohana Siyar
Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
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Vishva Sharma
Vishva Sharma
Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
The Diabetes Institute, Ohio University, Athens, Ohio, USA
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The Diabetes Institute, Ohio University, Athens, Ohio, USA
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Vishwajeet Puri
Vishwajeet Puri
Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
The Diabetes Institute, Ohio University, Athens, Ohio, USA
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The Diabetes Institute, Ohio University, Athens, Ohio, USA
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Kevin Y Lee
Kevin Y Lee
Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
The Diabetes Institute, Ohio University, Athens, Ohio, USA
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The Diabetes Institute, Ohio University, Athens, Ohio, USA
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factors for systemic insulin resistance ( Xu et al. 2003 ), although this viewpoint has been recently challenged ( Shimobayashi et al. 2018 , Espinosa De Ycaza et al. 2022 ). Several studies from our lab and others have demonstrated that
Baiyang You
Baiyang You
Cardiac Rehabilitation Center, Department of Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Yaoshan Dun
Yaoshan Dun
Cardiac Rehabilitation Center, Department of Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Wenliang Zhang
Wenliang Zhang
Cardiac Rehabilitation Center, Department of Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Lingjun Jiang
Lingjun Jiang
Cardiac Rehabilitation Center, Department of Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Hui Li
Hui Li
Cardiac Rehabilitation Center, Department of Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Murong Xie
Murong Xie
Cardiac Rehabilitation Center, Department of Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Yuan Liu
Yuan Liu
Cardiac Rehabilitation Center, Department of Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Suixin Liu
Suixin Liu
Cardiac Rehabilitation Center, Department of Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Introduction Insulin resistance (IR) is characterized by the reduction of insulin-stimulated glucose uptake and disposal in insulin target tissues including skeletal muscle, the liver, the heart and the adipose, which could be responsible for
Shaodong Guo
Shaodong Guo
Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A&M University Health Science Center, Scott & White, Central Texas Veterans Health Care System, 1901 South 1st Street, Bldg. 205, Temple, Texas 76504, USA
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Introduction Obesity, hyperglycemia, hyperlipidemia, and hypertension clustered together have been described as ‘insulin resistance syndrome’ or ‘syndrome X’ by Reaven et al . ( Reaven 1988 , Moller & Kaufman 2005 ). The constellation of metabolic
