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(average age 13–45 years) ( Burney & Giudice 2012 ). Debilitating pelvic pain, infertility in 50% of afflicted patients, considerable morbidity, and an economic burden of ~$50B a year in the United States alone accompany this condition. ENDO is often
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stress and obesity ( Kuo et al . 2007 ). We therefore used this chronic stress/pain paradigm to examine PVN CRH, adrenal NE and NPY, and circulating CORT and ACTH in sham and EA St 36 rats after 10 days of cold stress. We chose ST 36 because it is a
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reproductive age; may be asymptomatic. 40% of infertile patients may have endometriosis Three subtypes – aetiology may be different. Neuroinflammation and chronic pain. Changes in peritoneal environment. (Horne et al. 2017, Horne & Saunders 2019
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Introduction Endometriosis is a chronic, benign disease, which is characterized by the presence of endometrium-like tissue outside the uterine cavity, primarily on the ovaries. It is a major cause of symptoms such as pelvic pain, dysmenorrhea
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under the skin of its back (s.c.) with sterile saline (1 ml/kg body weight). The double-stress model consisted therefore of brief mother deprivation plus sham injection pain. Ten minutes later, they returned to the home cage with mother. The procedure
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Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea
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Innovative Research Institute for Cell Therapy, Seoul, Republic of Korea
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Innovative Research Institute for Cell Therapy, Seoul, Republic of Korea
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Introduction Although there are several drugs for treating diabetic peripheral neuropathy (DN), they are not curative but aim to alleviate the pain ( Ko & Cha 2012 ), and the main problem is that there are few treatment options that can
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(mean age 36 years) who underwent surgery for non-malignant, benign gynaecological disorders, such as fibroids, heavy menstruation and pelvic pain. Written consent to obtain tissue was provided by all patients and the Lothian Research Ethics Committee
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its mysteries has been progressing in recent years. A review from Western Australia emphasises that oxidative stress may be a main peripheral pathogenic mediator, and central regulation with sensitisation of pain requires further examination ( Ye et
Department of Comprehensive Reproductive Medicine, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5–8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
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Department of Comprehensive Reproductive Medicine, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5–8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
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Department of Comprehensive Reproductive Medicine, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5–8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
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Department of Comprehensive Reproductive Medicine, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5–8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
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Department of Comprehensive Reproductive Medicine, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5–8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
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Department of Comprehensive Reproductive Medicine, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5–8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
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Department of Comprehensive Reproductive Medicine, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5–8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
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regulates fever, swelling, pain, tumorigenesis, gastrointestinal protection, osteogenesis and wound healing ( Funk 2001 , Harris et al. 2002 , Murakami & Kudo 2004 ). PGE 2 production from arachidonic acid, which is released by phospholipase A 2 from
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other hand, inflammatory injury to the PSE frequently leads to adhesion formation with adverse clinical sequelae including pain, bowel obstruction and, in the female, infertility. Thus, despite their common embryological origin, the anti