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S Pearce, H Budge, A Mostyn, E Genever, R Webb, P Ingleton, A M Walker, M E Symonds, and T Stephenson

Introduction During late gestation, ovine fetal prolactin (PRL) secretion is maintained by a tonic stimulatory, rather than inhibitory, drive from the hypothalamus ( Houghton et al. 1995 , McMillen et al. 2001 ). Plasma PRL

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Y Feuermann, S J Mabjeesh, L Niv-Spector, D Levin, and A Shamay

-α , and prolactin regulate leptin expression at the adipose tissue ( Fruhbeck 2001 ). Prolactin, a hormone secreted from the pituitary acidophil cells, plays an important role in the morphological and biochemical differentiation of the epithelial cells

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Isoelectric focusing in polyacrylamide gel followed by staining with Coomassie brilliant blue was used for the densitometric estimation of ovine prolactin standard and canine pituitary prolactin. The results were compared with those obtained by conventional polyacrylamide gel electrophoretic procedures and isoelectric focusing was found to be a valid technique for the estimation of prolactin and to offer greater technical convenience.

The mobility of ovine and canine prolactin was similar in isoelectric focusing and gel electrophoresis. The isoelectric point of ovine and canine prolactin was found to be 6·17 and 6·61 respectively.

Constant levels of prolactin were found in the pituitaries of bitches at oestrus.

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C Zermeño, J Guzmán-Morales, Y Macotela, G Nava, F López-Barrera, J B Kouri, C Lavalle, G Martínez de la Escalera, and C Clapp

are unclear and little is known about the regulatory factors responsible for their control. Prolactin (PRL) acts both as a circulating hormone and as a cytokine in a vast array of physiological functions that range from reproduction and

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Jaroslav Kuneš, Veronika Pražienková, Andrea Popelová, Barbora Mikulášková, Jana Zemenová, and Lenka Maletínská

antiobesity drugs. Prolactin-releasing peptide in food intake regulation The anorexigenic neuropeptide prolactin-releasing peptide (PrRP) was initially isolated from the hypothalamus as a ligand for the human orphan G-protein-coupled receptor GPR10

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Eun-Jin Kang, So-Hye Hong, Jae-Eon Lee, Seung Chul Kim, Hoe-Saeng Yang, Pyong in Yi, Sang-Myeong Lee, and Beum-Soo An

Introduction Prolactin (PRL) is a polypeptide hormone synthesized and secreted from specialized cells of the anterior pituitary gland, which is known for its multiple effects on the female mammary gland, including regulation of growth and

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Jackson Nteeba, Kaiyu Kubota, Wenfang Wang, Hao Zhu, Jay L Vivian, Guoli Dai, and Michael J Soares

. 2009 , Rieck & Kaestner 2010 , Huang 2013 ). It is hypothesized that these maternal pancreatic adaptations are driven by the pregnancy hormones, prolactin (PRL) and placental lactogens (PLs), acting through the PRL receptor (PRLR) at the β cells

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R L Bogorad, T Y Ostroukhova, A N Orlova, P M Rubtsov, and O V Smirnova

Introduction Several prolactin receptor (PrlR) isoforms have been identified in mammals. In rat, they have been shown to be produced via alternative splicing of PrlR pre-mRNA: the formation of long and short isoforms result from

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T Clark Brelje, Nicholas V Bhagroo, Laurence E Stout, and Robert L Sorenson

series of in vivo and in vitro studies, we have shown that the activation of prolactin receptors by lactogenic hormones, either placental lactogen or prolactin, induces all of the known up-regulatory changes in islet function, which are known to be

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Department of Physiology, Middlesex Hospital Medical School, London W1P 6DB, and *Institut für Physiologie, Technische Universität München-Weihenstephan, West Germany

(Received 6 August 1974)

The release of both prolactin and oxytocin during lactation and machine milking in the cow is well established. Benson & Folley (1956) first suggested that oxytocin might initiate the release of prolactin. Bryant & Greenwood (1968), using a specific immunoassay for prolactin, were able to demonstrate this relationship. However, subsequent workers (Koprowski & Tucker, 1971; Schams, 1972) using exogenous oxytocin were unable to confirm these observations.

Experiments involving the use of exogenous oxytocin are inconclusive as it may not be possible to produce appropriate concentrations of oxytocin in the portal vessels to the hypophysis. Observations, therefore, were made on plasma samples taken frequently during milking and teat stimulation to elucidate the relationship between oxytocin and prolactin release. Release of the second neurohypophysial hormone, arginine-vasopressin (AVP), was also