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does not play a central functional role in sexual differentiation of the gonads in mouse, but is more important in maintaining granulosa cell identity postnatally. In mouse, Foxl2 is thought to be required to maintain the ovarian phenotype
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/c-met-dependent signaling ( Peruzzi & Bottaro 2006 ). Ovarian function Folliculogenesis Folliculogenesis is a dynamic process during which follicular granulosa cells (GCs) and theca cells proliferate and differentiate to produce factors (e.g., steroid and peptide hormones
The Bateson Centre, Department of Biomedical Science, Firth Court, University of Sheffield, Western Bank, Sheffield, UK
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The Bateson Centre, Department of Biomedical Science, Firth Court, University of Sheffield, Western Bank, Sheffield, UK
Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
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Introduction The roles of androgens in zebrafish sex differentiation, development of male sexual characteristics, and maintenance and function of the adult testes are poorly understood. Laboratory strains of zebrafish lack sex chromosomes and
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the developing gonad during a critical perinatal period. The same differentiating effects are also present in human sexual development ( Money et al . 1968 , Money & Ehrhardt 1971 ). During late embryonic life, and for roughly the first 7–10 days
Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Introduction Female sex steroids control proliferation and differentiation of target cells by altering the rates of specific gene transcription ( Tsai & O’Malley 1994 , Hall et al. 2001 , Li & O’Malley 2003 ). In the endometrium
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complement, gonadal hormones and neuronal steroid synthesis on the sexual differentiation of mammalian neurons . Journal of Neurogenetics 300 – 306 . ( https://doi.org/10.1080/01677063.2017.1390572 ) Ciofi P Leroy D Tramu G 2006 Sexual
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as a regulator of germ cells ( Morinaga et al . 2007 ). AMH's role as an essential inducer of male sexual differentiation also predates the Müllerian duct. In some species of fish, AMH regulates the differentiation of the gonads into testes, and
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mammalian sexual differentiation . Recent Progress in Hormone Research 50 349 – 364 . ( doi:10.1016/b978-0-12-571150-0.50021-4 )
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interfere with embryonic sexual differentiation in birds ( Groothuis & Schwabl 2008 , Hsu et al. 2016 ). Given the supraphysiological dosage of testosterone-[D5] we applied, this lack of a sex difference suggests that male and female embryos have similar
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Morphological and sexual differentiation extending far into postnatal life in the rat, a species with short gestation, is influenced in the female first by the absence and later by the presence of ovarian oestrogens. Therefore, in the present study the total oestrogen concentration was determined in the blood of normal female rats from the early postnatal critical period of hypothalamic sexual differentiation until sexual maturity.
Wistar rats aged 5–7 days were used. The animals were given heparin s.c. (5- and 10-day-old animals receiving 500 i.u., all others 1000 i.u.) and were killed by decapitation 45 min. later. At each age studied, blood from groups of 6–120 animals (Table 1) was pooled and replicate samples of 5 ml. were taken from each pool. The oestrogens were extracted and purified according to the method described in detail by Herzmann, Presl, Horský & Vrchlabská (1967) and were measured fluorimetrically (Ittrich, 1960).
The results
