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J L Crawford Reproduction Group, AgResearch Ltd, Wallaceville Animal Research Centre, Ward Street, PO Box 40063, Upper Hutt, New Zealand

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B P Thomson Reproduction Group, AgResearch Ltd, Wallaceville Animal Research Centre, Ward Street, PO Box 40063, Upper Hutt, New Zealand

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M F Beaumont Reproduction Group, AgResearch Ltd, Wallaceville Animal Research Centre, Ward Street, PO Box 40063, Upper Hutt, New Zealand

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D C Eckery Reproduction Group, AgResearch Ltd, Wallaceville Animal Research Centre, Ward Street, PO Box 40063, Upper Hutt, New Zealand

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possums in this study and in one possum from an identical experiment undertaken at AgResearch Invermay, where possums were sampled near the day of ovulation. In these five possums, a surge (5–8 h in duration) of plasma LH and a coincident, but slightly

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Cristina Capatina Department of Endocrinology, CI Parhon National Institute of Endocrinology, Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Endocrinology, CI Parhon National Institute of Endocrinology, Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

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John A H Wass Department of Endocrinology, CI Parhon National Institute of Endocrinology, Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

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symptoms onset to diagnosis is usually about 7–10 years ( Rajasoorya et al . 1994 ), at the time of diagnosis many patients present with specific complications of the disease. The most prevalent comorbidities are arterial hypertension, sleep apnea

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S A Cavigelli
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S L Monfort
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T K Whitney
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Y S Mechref
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M Novotny
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M K McClintock
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circadian glucocorticoid rhythm is altered in several pathological states; e.g. major depressive disorder ( Sachar et al. 1973 , Linkowski et al. 1985 , Pfohl et al. 1985 ), Alzheimer’s disease, sleep deprivation ( Spiegel et al. 1999 ), and normal

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J Bancroft The Kinsey Institute, Indiana University, Morrison Hall third floor, Bloomington, Indiana 47405, USA

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sleep parameters, and did not affect frequency, degree or duration of NPT, when assessed as penile circumference, but did increase, modestly but significantly, penile rigidity during NPT. Testosterone manipulation in eugonadal men has

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Jennifer A Evans Department of Biomedical Sciences, Marquette University, Milwaukee, WI, USA

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energy resources ( Fig. 1 , Takahashi et al . 1968 ). Likewise, the secretion of growth hormone is highest during slow-wave sleep when its ability to repair and strengthen bones is most effective ( Fig. 1 , Takahashi et al . 1968 ). In both cases, the

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Adrián Báez-Ruiz Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México
Department of Cellular Physiology, Faculty of Science, UASLP, San Luis Potosí, México

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Natalí N Guerrero-Vargas Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México
Department of Anatomy, Faculty of Medicine, UNAM, DF, México

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Fernando Cázarez-Márquez Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México

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Elizabeth Sabath Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México

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María del Carmen Basualdo Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México

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Roberto Salgado-Delgado Department of Cellular Physiology, Faculty of Science, UASLP, San Luis Potosí, México

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Carolina Escobar Department of Anatomy, Faculty of Medicine, UNAM, DF, México

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Ruud M Buijs Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, México

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glucocorticoids, used to treat inflammatory diseases. Interestingly, there is also evidence that in addition to the dose and treatment duration; when corticosterone is given at the time of day when the normal peak occurs less severe side effects are noted ( Wu et

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Sebastio Perrini Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, I-70124 Bari, Italy

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Luigi Laviola Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, I-70124 Bari, Italy

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Marcos C Carreira Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, I-70124 Bari, Italy

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Angelo Cignarelli Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, I-70124 Bari, Italy

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Annalisa Natalicchio Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, I-70124 Bari, Italy

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Francesco Giorgino Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, I-70124 Bari, Italy

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onset of slow-wave sleep and less conspicuous secretory episodes a few hours after meals ( Ho et al . 1988 , Hartman et al . 1991 ), and is controlled by the action of two hypothalamic factors, GHRH, which stimulates GH secretion, and somatostatin

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J Cantley School of Medicine, University of Dundee, Dundee, United Kingdom of Great Britain and Northern Ireland

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D L Eizirik ULB Center for Diabetes Research, Université Libre de Bruxelles Faculté de Médecine, Bruxelles, Belgium

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E Latres JDRF International, New York, NY, USA

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C M Dayan Cardiff University School of Medicine, Cardiff, United Kingdom of Great Britain and Northern Ireland

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the JDRF-DiabetesUK-INNODIA-nPOD Stockholm Symposium 2022
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the JDRF-DiabetesUK-INNODIA-nPOD Stockholm Symposium 2022

autoimmune component in T1D remains strong, including the presentation of a moving 3D image of an nPOD donor (20-year-old T1D subject with 7 months disease duration) stained for glucagon and CD3, clearly demonstrating the presence of immune cells within the

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Cátia F Gonçalves Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK

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Qing-Jun Meng Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK

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median raphe nucleus ( Challet & Pévet 2003 , Dibner et al. 2010 ). The SCN clock regulates daily oscillations in mammalian behaviour and physiology, including locomotor activity, sleep–wake cycles, blood pressure, body temperature, pineal melatonin

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S Pearce
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H Budge
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A Mostyn
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E Genever
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R Webb
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P Ingleton
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A M Walker
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M E Symonds
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T Stephenson
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(pre-PRL, 47.6 ± 0.6 ng/ml; post-PRL, 240.5 ± 3.5 ng/ml; P< 0.001) that was maintained over the 6-day duration. Administration of S179D PRL resulted in an acute rise in colonic temperature at both 2 and 6 days of age (Fig. 5 ). Following repeated

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