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Manuel D Gahete Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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Juan M Jiménez-Vacas Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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Emilia Alors-Pérez Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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Vicente Herrero-Aguayo Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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Antonio C Fuentes-Fayos Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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Sergio Pedraza-Arévalo Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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Justo P Castaño Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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Raúl M Luque Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology, and Immunology, Universidad de Córdoba, Córdoba, Spain
Reina Sofia University Hospital, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain
Agrifood Campus of International Excellence (ceiA3), Córdoba, Spain

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dysplasia and hyperplasia. Second, ectopic Wnt activation in the adrenal cortex has been implemented through conditional loss of Apc , an upstream inhibitor of the Wnt pathway, similar to that observed clinically in some sporadic ACC patients ( Assie et al

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0571
Volume/Issue:
Volume 240: Issue 3
Free access
Scott Haston Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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Saba Manshaei Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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Juan Pedro Martinez-Barbera Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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in the CTNNB1 gene, encoding β-catenin ( Buslei et al. 2005 ). These mutations are thought to impair the proteosomal degradation of this protein, resulting in its nucleo-cytoplasmic accumulation and subsequent upregulation of the Wnt pathway

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0258
Volume/Issue:
Volume 236: Issue 1
Open access
Ying-Ying Tsai Department of Physiology, Medical College of Georgia at Augusta University (formerly Georgia Regents University), Augusta, Georgia, USA

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William E Rainey Departments of Molecular & Integrative Physiology and Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

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Wendy B Bollag Department of Physiology, Medical College of Georgia at Augusta University (formerly Georgia Regents University), Augusta, Georgia, USA
Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia, USA

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increased expression of the VLDL receptor ( Liu et al . 2009 ). Additionally, VLDL appears to be a negative regulator of the Wnt pathway in endothelial cells, in which selective knockdown of its receptor resulted in the upregulation of low

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0237
Volume/Issue:
Volume 232: Issue 2
Free access
Eric W-F Lam Cancer Research-UK Laboratories, Institute of Reproductive and Developmental Biology, Division of Cancer and

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Kunal Shah Cancer Research-UK Laboratories, Institute of Reproductive and Developmental Biology, Division of Cancer and

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Jan J Brosens Cancer Research-UK Laboratories, Institute of Reproductive and Developmental Biology, Division of Cancer and

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the activity of upstream pathways. For example, FOXO transcription factors bind to SMAD3 and SMAD4 in response to transforming growth factor-β (TGF-β) signalling and to β-catenin upon activation of the canonical WNT pathway ( Seoane et al . 2004

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0480
Volume/Issue:
Volume 212: Issue 1
Free access
Kevin M Sargent Department of Animal Science, University of Nebraska-Lincoln, Animal Science Building, 3940 Fair Street, Lincoln, Nebraska 68583‐0908, USA

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Renee M McFee Department of Animal Science, University of Nebraska-Lincoln, Animal Science Building, 3940 Fair Street, Lincoln, Nebraska 68583‐0908, USA

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Renata Spuri Gomes Department of Animal Science, University of Nebraska-Lincoln, Animal Science Building, 3940 Fair Street, Lincoln, Nebraska 68583‐0908, USA

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Andrea S Cupp Department of Animal Science, University of Nebraska-Lincoln, Animal Science Building, 3940 Fair Street, Lincoln, Nebraska 68583‐0908, USA

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( DiTacchio et al . 2012 ). FGF9 Elimination of FGF9 or its receptor FGFR2 (fibroblast growth factor receptor 2) can cause male-to-female sex reversal given that FGF9 downregulates or suppresses the Wnt pathway that would otherwise promote female gonadal

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0342
Volume/Issue:
Volume 227: Issue 2
Free access
Erica Yeo Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada

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Patricia L Brubaker Department of Physiology, University of Toronto, Toronto, ON, Canada
Department of Medicine, University of Toronto, Toronto, ON, Canada

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Deborah M Sloboda Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
Department of Obstetrics, Gynecology and Pediatrics, McMaster University, Hamilton, ON, Canada

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investigated these signaling pathways in the maternal L-cell during pregnancy, although genetic variants of TCF proteins (nuclear Wnt pathway components) have been associated with the development of GDM ( Shaat et al. 2007 , Reyes-López et al. 2014 ). But

Article Type:
Review Article
Collections:
Gut microbiome special collection
DOI:
https://doi.org/10.1530/JOE-21-0354
Volume/Issue:
Volume 253: Issue 1
Open access
Kyriaki S Alatzoglou Clinical and Academic Lead in Endocrinology, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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Daniel Kelberman Clinical and Academic Lead in Endocrinology, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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Mehul T Dattani Clinical and Academic Lead in Endocrinology, Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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through the restriction of Six6 expression within the pouch. The similarity in the morphological abnormalities of Rathke's pouch between Sox3 mutants and mutants involving the Wnt pathway suggest their interplay during pituitary organogenesis. An

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0447
Volume/Issue:
Volume 200: Issue 3
Free access
Ulla-Maj Fiúza Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK

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Alfonso Martinez Arias Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK

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is increasing evidence for the involvement of the Wnt pathway ( Palmeirim et al. 1997 , Pasini et al. 2001 , Aulehla et al. 2003 , Giudicelli & Lewis 2004 ). Looking at the Drosophila wing imaginal disc example, Notch signalling

Article Type:
Review Article
DOI:
https://doi.org/10.1677/JOE-07-0242
Volume/Issue:
Volume 194: Issue 3
Free access
Marlise Guerrero Schimpf Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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María M Milesi Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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Enrique H Luque Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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Jorgelina Varayoud Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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included alterations in endocrine-dependent mechanisms involved in decidualization that leaded to post-implantation embryo loss. These alterations encompassed a dysregulation of ESR1-PR signaling ( Ingaramo et al. 2016 ) and Wnt pathways ( Ingaramo et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0207
Volume/Issue:
Volume 239: Issue 2
Free access
Leke Wiering Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Junior Clinician Scientist Program, Berlin, Germany

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Frank Tacke Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany

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tumorous liver. Namodenoson induces an anti-inflammatory effect via deregulation of NF-κb and Wnt pathways. In the phase II study, a dose-dependent alanine aminotransferase (ALT) reduction was achieved ( Safadi et al. 2021 ). Other promising

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0194
Volume/Issue:
Volume 256: Issue 1
Free access