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Department of Pathology, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany
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Department of Pathology, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany
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Department of Pathology, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany
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Department of Pathology, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany
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Department of Pathology, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany
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Department of Pathology, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany
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by elevating adiponectin level in vivo. However, rosiglitazone has side effects such as promoting adipogenesis, causing body weight gain and recently shown to increase cardiovascular risk. Therefore, a small molecule that enhances adiponectin
Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9
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Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9
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Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9
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-adipogenic factors may be informative. Platelet-derived growth factor (PDGF) is a negative regulator of adipogenesis ( Hauner et al . 1995 , Krieger-Brauer & Kather 1995 , Artemenko et al . 2005 ). PDGF receptor (PDGFR) mRNA and protein levels fall during 3T3-L1
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Department of Pharmacology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA
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activity in vitro , using 3T3-L1 cells, suppressed adipogenesis. Our study highlights the unique functions of CBP and p300 in the regulation of fat remodeling and development and provides evidence for the therapeutic potential of CBP- and p300-selective
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variability in donor characteristics. Thus, PAPPA expression in preadipocytes may be an intrinsic property of the fat depots and may play a role in depot-specific adipogenesis ( Tchkonia et al . 2002 ). Proinflammatory cytokines IL1β and TNFα are potent
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addition, adipogenic effects of LIF have been indicated by enhanced activity of glycerol-phosphate dehydrogenase and accumulation of lipid in Ob1771 cells during adipogenesis ( Aubert et al. 1999 ). However, other findings have shown that LIF prevents
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Department of Physiology, Augusta University, Augusta, Georgia, USA
Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA
Charlie Norwood VA Medical Center, Augusta, Georgia, USA
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Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA
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Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Augusta University, Augusta, Georgia, USA
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Department of Orthopaedic Surgery, Augusta University, Augusta, Georgia, USA
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function and bone health. Recent studies have uncovered an intricate relationship between caloric intake and bone. For example, chronic caloric deficit induces high bone marrow adipogenesis accompanied by osteopenia in humans and mice ( Devlin et al
Department of Biological Sciences, Biomedical Research Institute, University of Warwick, Gibbett Hill Road, Coventry CV4 7AL, UK
Warwickshire Nuffield Hospital, Leamington Spa, Warwickshire, CV32 6RW, UK
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Department of Biological Sciences, Biomedical Research Institute, University of Warwick, Gibbett Hill Road, Coventry CV4 7AL, UK
Warwickshire Nuffield Hospital, Leamington Spa, Warwickshire, CV32 6RW, UK
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Department of Biological Sciences, Biomedical Research Institute, University of Warwick, Gibbett Hill Road, Coventry CV4 7AL, UK
Warwickshire Nuffield Hospital, Leamington Spa, Warwickshire, CV32 6RW, UK
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Department of Biological Sciences, Biomedical Research Institute, University of Warwick, Gibbett Hill Road, Coventry CV4 7AL, UK
Warwickshire Nuffield Hospital, Leamington Spa, Warwickshire, CV32 6RW, UK
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Department of Biological Sciences, Biomedical Research Institute, University of Warwick, Gibbett Hill Road, Coventry CV4 7AL, UK
Warwickshire Nuffield Hospital, Leamington Spa, Warwickshire, CV32 6RW, UK
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Department of Biological Sciences, Biomedical Research Institute, University of Warwick, Gibbett Hill Road, Coventry CV4 7AL, UK
Warwickshire Nuffield Hospital, Leamington Spa, Warwickshire, CV32 6RW, UK
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adipogenesis and modulation of adipocytes-specific genes ( Kintscher & Law 2005 ). In human adipose tissue, PPARγ-2 is the predominant isoform and is more highly expressed in s.c. compared with Ome adipose tissue ( Giusti et al. 2005 ). Furthermore, studies
University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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Visfatin mRNA expression is high in 3T3-L1 adipocytes and stimulated during adipogenesis We compared expression of visfatin in 3T3-L1 adipocytes in vitro to visceral and subcutaneous fat depots of mice in vivo. As shown in Fig. 1A , visfatin
Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
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Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea
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Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea
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Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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adipocytes ( Stephens et al . 1996 ). The phosphorylation of STAT5 promotes adipogenesis, is associated with the glucocorticoid receptor (GR) ( Floyd & Stephens 2003 ) and increases the level of PPARγ stimulated by growth hormone regulation ( Kawai et al
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Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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glucocorticoid axis within the adipocyte. The enhanced fat mass seen at birth is thus associated with endocrine changes which are likely to have contributed to increased rates of adipogenesis both during late gestation and continuing after birth. These findings