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J Jeyabalan
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M Shah
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B Viollet Department of Veterinary Basic Sciences, INSERM, CNRS, Université Paris Decartes, INSERM, Department of Endocrinology, Royal Veterinary College, Royal College Street, London NW1 0TU, UK
Department of Veterinary Basic Sciences, INSERM, CNRS, Université Paris Decartes, INSERM, Department of Endocrinology, Royal Veterinary College, Royal College Street, London NW1 0TU, UK
Department of Veterinary Basic Sciences, INSERM, CNRS, Université Paris Decartes, INSERM, Department of Endocrinology, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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J P Roux Department of Veterinary Basic Sciences, INSERM, CNRS, Université Paris Decartes, INSERM, Department of Endocrinology, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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P Chavassieux Department of Veterinary Basic Sciences, INSERM, CNRS, Université Paris Decartes, INSERM, Department of Endocrinology, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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M Korbonits Department of Veterinary Basic Sciences, INSERM, CNRS, Université Paris Decartes, INSERM, Department of Endocrinology, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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C Chenu
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ovariectomised or sham operated. Tibiae were collected from these mice 6 weeks after OVX for micro-computed tomography (micro-CT) analysis. For measurement of dynamic bone formation parameters, mice in this study were i.p. injected with calcein (Sigma

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0184
Volume/Issue:
Volume 214: Issue 3
Open access
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Idris Mohamed Metabolism Laboratory, Winthrop-University Hospital, Mineola, New York 11501, USA

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James K Yeh Metabolism Laboratory, Winthrop-University Hospital, Mineola, New York 11501, USA

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experience suggests that 4 day intervals of calcein injection would be too short to distinguish the double labeling clearly when the animal's age is over 3 months or more, as their bone formation and bone turnover rates decrease compared with that of the 1

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0532
Volume/Issue:
Volume 202: Issue 2
Free access
C Zermeño Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, 07360, México
Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, 76230 Querétaro, México

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J Guzmán-Morales Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, 07360, México
Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, 76230 Querétaro, México

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Y Macotela Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, 07360, México
Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, 76230 Querétaro, México

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G Nava Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, 07360, México
Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, 76230 Querétaro, México

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F López-Barrera Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, 07360, México
Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, 76230 Querétaro, México

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J B Kouri Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, 07360, México
Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, 76230 Querétaro, México

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C Lavalle Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, 07360, México
Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, 76230 Querétaro, México

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G Martínez de la Escalera Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, 07360, México
Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, 76230 Querétaro, México

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C Clapp Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, 07360, México
Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, 76230 Querétaro, México

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the tissue; their death is an important feature of cartilage replacement during bone formation ( Poole 1991 ), but in aging and disease it can lead to cartilage degradation ( Aigner & McKenna 2002 ). Various lines of evidence suggest that apoptosis is

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.1.06766
Volume/Issue:
Volume 189: Issue 2
Free access
Corine Martineau
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Louise Martin-Falstrault Laboratoire du Métabolisme Osseux, Laboratoire du Métabolisme des Lipoprotéines, BioMed, Département des Sciences Biologiques Université du Québec à Montréal, Case Postale 8888, Succursale Centre-ville, Montréal, Quebec, Canada H3C 3P8

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Louise Brissette Laboratoire du Métabolisme Osseux, Laboratoire du Métabolisme des Lipoprotéines, BioMed, Département des Sciences Biologiques Université du Québec à Montréal, Case Postale 8888, Succursale Centre-ville, Montréal, Quebec, Canada H3C 3P8

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Robert Moreau
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between bone formation and resorption involves the regulation of bone cell activities by several endocrine and paracrine axes including steroid hormones ( Frenkel et al . 2010 ), adrenocorticotropic hormone (ACTH; Isales et al . 2010 ), and cytokines

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0147
Volume/Issue:
Volume 222: Issue 2
Free access
J Jeyabalan
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M Shah
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B Viollet Royal Veterinary College, Institut Cochin, Royal College Street, London NW1 0TU, UK

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C Chenu
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al . 1996 , Ducy 2000 ). The bone loss in age-related osteoporosis is associated with more adipogenesis and less bone formation ( Pei & Tontonoz 2004 ). Second, there are direct actions on bone of hormones produced by adipocytes, such as adiponectin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0306
Volume/Issue:
Volume 212: Issue 3
Free access
Timothy J Dreyer Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK

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Jacob AC Keen Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK

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Leah M Wells Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK

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Scott J Roberts Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK

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Introduction Sclerostin is a 22 kDa secreted glycoprotein encoded by the SOST gene. It is primarily expressed by osteocytes and plays a major role in bone homeostasis, affecting bone formation and bone remodelling through its role as a

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0209
Volume/Issue:
Volume 257: Issue 2
Free access
Hiroki Saito
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Tomoya Nakamachi Department of Pharmacology, Department of Anatomy, Department of Clinical Pharmacy and Pharmacology, Department of Internal Medicine, Department of Molecular Pharmacology, Graduate School of Medical and Dental Science, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan

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Kazuhiko Inoue
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Ryuji Ikeda Department of Pharmacology, Department of Anatomy, Department of Clinical Pharmacy and Pharmacology, Department of Internal Medicine, Department of Molecular Pharmacology, Graduate School of Medical and Dental Science, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan

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Kazuo Kitamura Department of Pharmacology, Department of Anatomy, Department of Clinical Pharmacy and Pharmacology, Department of Internal Medicine, Department of Molecular Pharmacology, Graduate School of Medical and Dental Science, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan

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Naoto Minamino Department of Pharmacology, Department of Anatomy, Department of Clinical Pharmacy and Pharmacology, Department of Internal Medicine, Department of Molecular Pharmacology, Graduate School of Medical and Dental Science, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan

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Seiji Shioda Department of Pharmacology, Department of Anatomy, Department of Clinical Pharmacy and Pharmacology, Department of Internal Medicine, Department of Molecular Pharmacology, Graduate School of Medical and Dental Science, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan

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Atsuro Miyata
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N mbr are expressed in mouse ATDC5 chondrogenic cells, which proliferate in response to NMB ( Saito et al . 2012 ). Bone tissue is primarily made via two mechanisms. During endochondral bone formation in long bones and vertebrae, a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0488
Volume/Issue:
Volume 217: Issue 2
Free access
Yongmei Wang Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94117-1080, USA
Department of Radiology, University of California, San Francisco, California 94117-1080, USA

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Takeshi Sakata Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94117-1080, USA
Department of Radiology, University of California, San Francisco, California 94117-1080, USA

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Hashem Z Elalieh Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94117-1080, USA
Department of Radiology, University of California, San Francisco, California 94117-1080, USA

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Scott J Munson Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94117-1080, USA
Department of Radiology, University of California, San Francisco, California 94117-1080, USA

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Andrew Burghardt Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94117-1080, USA
Department of Radiology, University of California, San Francisco, California 94117-1080, USA

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Sharmila Majumdar Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94117-1080, USA
Department of Radiology, University of California, San Francisco, California 94117-1080, USA

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Bernard P Halloran Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94117-1080, USA
Department of Radiology, University of California, San Francisco, California 94117-1080, USA

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Daniel D Bikle Department of Medicine, Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, California 94117-1080, USA
Department of Radiology, University of California, San Francisco, California 94117-1080, USA

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. To determine bone formation during the period of PTH administration, the mice were injected s.c. with calcein on day 0 of PTH administration followed in 12 days by demeclocycline (each 15 mg/kg) to label the mineralization fronts of the bone. Two days

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06351
Volume/Issue:
Volume 189: Issue 2
Free access
Yan-Hong Bu Institute of Metabolism and Endocrinology, Department of Clinical Laboratory, Department of Orthopaedics, The Second Xiang-Ya Hospital of Central South University, 410011 ChangSha, People's Republic of China
Institute of Metabolism and Endocrinology, Department of Clinical Laboratory, Department of Orthopaedics, The Second Xiang-Ya Hospital of Central South University, 410011 ChangSha, People's Republic of China

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Yu-Ling He Institute of Metabolism and Endocrinology, Department of Clinical Laboratory, Department of Orthopaedics, The Second Xiang-Ya Hospital of Central South University, 410011 ChangSha, People's Republic of China

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Hou-De Zhou Institute of Metabolism and Endocrinology, Department of Clinical Laboratory, Department of Orthopaedics, The Second Xiang-Ya Hospital of Central South University, 410011 ChangSha, People's Republic of China

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Wei Liu Institute of Metabolism and Endocrinology, Department of Clinical Laboratory, Department of Orthopaedics, The Second Xiang-Ya Hospital of Central South University, 410011 ChangSha, People's Republic of China

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Dan Peng Institute of Metabolism and Endocrinology, Department of Clinical Laboratory, Department of Orthopaedics, The Second Xiang-Ya Hospital of Central South University, 410011 ChangSha, People's Republic of China

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Ai-Guo Tang Institute of Metabolism and Endocrinology, Department of Clinical Laboratory, Department of Orthopaedics, The Second Xiang-Ya Hospital of Central South University, 410011 ChangSha, People's Republic of China

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Ling-Li Tang Institute of Metabolism and Endocrinology, Department of Clinical Laboratory, Department of Orthopaedics, The Second Xiang-Ya Hospital of Central South University, 410011 ChangSha, People's Republic of China

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Hui Xie Institute of Metabolism and Endocrinology, Department of Clinical Laboratory, Department of Orthopaedics, The Second Xiang-Ya Hospital of Central South University, 410011 ChangSha, People's Republic of China

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Qiu-Xia Huang Institute of Metabolism and Endocrinology, Department of Clinical Laboratory, Department of Orthopaedics, The Second Xiang-Ya Hospital of Central South University, 410011 ChangSha, People's Republic of China

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Xiang-Hang Luo Institute of Metabolism and Endocrinology, Department of Clinical Laboratory, Department of Orthopaedics, The Second Xiang-Ya Hospital of Central South University, 410011 ChangSha, People's Republic of China

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Er-Yuan Liao Institute of Metabolism and Endocrinology, Department of Clinical Laboratory, Department of Orthopaedics, The Second Xiang-Ya Hospital of Central South University, 410011 ChangSha, People's Republic of China

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developed via different cellular mechanisms: in the case of the Irs1 −/− mice, both bone formation and resorption were decreased ( Ogata et al . 2000 ), whereas in the Irs2 −/− mice, decreased bone formation and increased bone resorption were noted

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0064
Volume/Issue:
Volume 206: Issue 3
Free access
Russell T Turner Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA

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Kenneth A Philbrick Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA

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Amida F Kuah Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA

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Adam J Branscum Biostatistics Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA

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Urszula T Iwaniec Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA

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et al . 2013 ). The lower bone formation generally reported in these mice is primarily due to reduced osteoblast number, although reduced osteoblast activity has also been noted. The dramatic increase in bone marrow adipose tissue (MAT) in long bones

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0103
Volume/Issue:
Volume 233: Issue 3
Free access